Biochemistry and Biomedical Sciences
Assistant Professor - Biology
329 Life Sciences Building
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- Streptomyces Development and Regulation
Our research program addresses fundamental questions pertaining to multicellular development, gene regulation and antibiotic production using the bacterium Streptomyces coelicolor as our model system. The streptomycetes are Gram-positive, soil-dwelling bacteria renowned for their metabolic diversity and their morphological complexity. They produce a vast array of compounds having a profound medical benefit, including anti-cancer agents, immunosuppressants, and more than 80% of commercially important antibiotics. In addition, Streptomyces have a multicellular life-cycle, differentiating into distinct tissue types in response to environmental stimuli, and provide a unique opportunity to explore cell differentiation in a simple, bacterial system. Using genetic, biochemical, cell-biological and post-genomic technologies, the ultimate aim of our research program is to understand how cellular differentiation is achieved in a multicellular bacterium; to understand how newly discovered regulators contribute to differentiation, metabolism, and environmental adaptation; and to develop ways of stimulating production of new antibiotics for treatment of resistant infections.