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Faculty of Health Sciences
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RESEARCH
Associate Faculty Areas of Interest
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Atkinson, Stephanie
Stephanie Atkinson´s laboratory in child health research investigates early determinants of development that impact on metabolic imprinting associated with chronic disease risk, targeting osteoporosis, obesity, and cardiovascular disease. Methodologies include functional indicator biomarkers, imaging techniques for body composition, stable isotope tracers and gene expression of metabolic regulatory proteins.
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Bramson, Jonathan
Jonathan Bramson´s lab studies the maintenance of immune homeostasis with particular emphasis on the ways that viruses and tumors disturb this homeostasis. The lab´s objective is to use this understanding to develop strategies to control virus infections and cancers.
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Brennan, John
The Brennan´s research group´s goal is to develop solid-phase affinity-based assays suitable for: 1) high-throughput screening of complex small molecule mixtures against immobilized protein targets and; 2) biosensing of toxins and patogens. Our research encompasses the development of new sol-gel methods for protein immobilization, evaluation of entrapped protein performance, and the design of new devices and assay formats for sensing and HTS.
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Elliott, MarieThe Elliot lab is working to address fundamental questions in the areas of antibiotic production, bacterial gene regulation by non-coding RNAs, and multicellular differentiation using simple bacterial systems. Trainees in the Elliot lab use a variety of genetic, biochemical and cell biological techniques to probe, manipulate and understand these different systems.
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Gauldie, Jack
Research interests include investigating the cell and molecular mechanisms that regulate the host inflammatory response and innate immune response. The tissues of interest are mucosa (lung and gut) through which most pathogens infect the host. How infections interact with the mucosal innate system is an area of recent activity.
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Gilberger, TimDr. Gilberger's research focuses on molecular mechanisms of pathogenesis of malaria parasite pathogens.
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Dr. Hill's research focuses on biomarkers of cardiac injury and
evidence-based laboratory medicine.
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Larché, Mark
Dr. Larché's research involves studying the development of peptide immunotherapy for immunological diseases.
The research may lead to the development of new treatments for immunological diseases.
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Dr. Leber is an Associate Member of the Department of Biochemistry he collaborates with Dr. David Andrews on studies investigating basic biochemical mechanisms in apoptosis.
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Mossman, Karen
Karen ´s laboratory studies aspects of virus:host interactions, including mechanisms used by cells to recognize virus particle entry and strategies utilized by viruses to counteract these responses. This information is being used to develop viruses as oncolytic vectors for cancer therapy, based on the ability of viruses to exploit cellular defects involved in cell transformation.
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Raha, SandeepDr. Raha's lab focuses on understanding the role of mitochondrial function/dysfunction in modulating uterine stress as a consequence of maternal obesity. We focus on how physiological stressors affect mitochondrial function and one of their primary by-products, reactive oxygen species. We are interested in understanding the role of mitochondria in contributing to fetal stress in the obese mother. Furthermore, we also focus on how in utero stress can affect mitochondrial function and signaling in dictating fetal and neonatal health of obese mothers. We utilize cell culture and animal models to understand these processes and develop therapeutic strategies to minimize the consequences of maternal obesity on neonatal health.
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Singh, Sheila
Dr. Singh is a surgeon scientist whose research program is centred on the study of brain cancer stem cells. She recently identified an abnormal stem cell that may drive the formation of brain tumours. Her research program will focus on further molecular and genetic characterization of the brain tumour initiating cell (BTIC), and the molecular signalling pathways that are dysregulated in this cell to allow for brain tumorigenesis.
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Weitz, Jeffrey
Focussing on thrombosis, the root cause of most heart attacks and strokes, the laboratory explores the biochemistry of blood coagulation and fibrinolysis and the mechanism of action of drugs used to treat thrombosis. Enzyme kinetics, molecular biology techniques and measurements of protein/protein interactions are used to study key reactions. Animal models of thrombosis and the bidirectional translation of discoveries from patients to the laboratory and from the laboratory to patients allows a true bench to bedside approach to research.
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