We are investigating the functions of tail-anchored membrane proteins including: the molecular mechanisms by which Bcl-2 family proteins regulate apoptosis and the response of cancer cells to chemotherapy, the roles of tail-anchor proteins in the assembly of intracellular membranes and organelles, and signaling by tail-anchor proteins involved in differentiation of stem cells.
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The Berti lab studies enzyme mechanisms and transition states. Our goals are to better understand catalysis, and to create new enzyme inhibitors that will one day lead to new therapies. Trainees in the Berti lab use tools ranging from molecular biology to computational chemistry to understand how enzymes work.
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Mick Bhatia´s research examines the parallels between the behaviour of human stem cells and the initial stages of the development of human cancer in order to advance understanding of how cancer begins.
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Russell Bishop´s Laboratory is focused on one of the most important and challenging problems in contemporary biochemistry; namely, the structure and function of membrane proteins. Trainees in the Bishop Research Group are integrating genetics, biochemistry, and chemical biology to determine how the bacterial outer membrane permeability barrier provides resistance to antibiotics.
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Eric Brown´s Laboratory is tackling multi-drug resistant bacteria with research into new avenues for antibacterial therapies. Trainees in the Brown Research Group are using the tools of bacterial genetics, biochemistry and chemical biology to understand and subvert the remarkable survival strategies of bacteria.
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The Burrows laboratory studies bacterial motility, protein secretion and biofilm formation. We are interested in how complicated structures like type IV pili and type II secretion systems involved in bacterial virulence are assembled in the bacterial cell envelope and cross the peptidoglycan layer that holds the cell together. We are also interested in finding small molecules that affect motility, secretion and biofilm formation; such compounds have the potential to lead to new types of drugs that impair bacterial pathogenicity without actually killing the cells.
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The Capone lab studies Eukaryotic gene expression and regulation/mammalian and viral transcription factors/nuclear hormone receptor.
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Brian Coombes´ laboratory performs research on the molecular and genetic basis of bacterial virulence. The aim of this research is to understand how bacterial pathogens alter host cell biology to subvert innate immunity, promote bacterial pathogenesis and to alter the progression and outcome of disease following infection of hosts.
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Brad Doble´s Laboratory is studying the mechanisms regulating the unique properties of stem cells. Techniques used in the Doble lab include: targeted gene manipulation in cells and animals; stem cell differentiation assays (embryoid bodies and teratomas); live cell imaging; biochemical analyses of signaling pathways; and proteomic and genomic analyses.
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His research at McMaster will seek to expand our understanding of the mechanisms that guide the differentiation of human ES and iPS cells along discrete lineages into tissue that are relevant to clinical therapies and drug discovery.
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Richard Epand´s lab has an interest in the functions of biological membranes. The membrane provides a unique environment for organizing molecules and for dividing compartments. Studies range from the properties of proteins in membranes to the study of membrane components in living cells.
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Cecile Fradin´s lab is interested in studying the dynamics of single molecules inside biological systems using optical tools. Dynamics is essential to the survival of the cell, which is a biological unit in permanent evolution, and which has to be able to process and react to information. Dynamical processes inside the cell happen on a very wide range of length and time-scales, and are governed by complex and intricate rules and mechanisms. At the scale of the molecule, they are of interest for the physicist as well as for the biologist, since they involve basic transformation of chemical or thermal energy into mechanical energy. In order to unravel their exact mechanisms, in vivo quantitative measurements at the single molecule level are required, which recent developments in the domain of fluorescence techniques, single molecule detection, and recombinant protein technology now offers the possibility to do.
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Alba Guarne´s Laboratory studies how cells coordinate DNA replication and DNA repair to ensure that their genetic information is faithfully passed onto the progeny. Trainees in the Guarne Research Group use X-ray crystallography, biochemistry, molecular and cell biology to understand the mechanisms that regulate these essential processes.
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The Gupta lab´s main research are studies on functional and evolutionary genomics, studies on mitochondrial and heat shock proteins and studies on adenosine kinase and related enzymes.
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The Hassell lab´s main research areas are cancer biology, therapeutics and biochemistry.
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The Higgs lab´s main research areas are Biophysics and Bioinformatics.
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Our research program is focused on dissecting the molecular
regulation of normal and malignant hematopoietic stem cell (HSC)
self-renewal and hopes to identify the underlying processes that
ultimately lead to leukemic transformation and progression.
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Research in the Junop lab is focused on understanding the molecular mechanisms governing the repair of various types of DNA damage. Bacterial, yeast and human repair pathways are studied using a variety of genetic and biochemical tools with the primary emphasis being determination of macromolecular structure using X-ray crystallography.
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Yingfu Li´s Laboratory investigates novel functions of DNA and RNA as enzymes and receptors and utilizes these so-called ´functional nucleic acids´ for innovative applications in areas including biosensing, and biomedicine and nanotechnology. Researchers in the Li Group explore a variety of chemistry, biochemistry and chemical biology approaches to discover desirable functional nucleic acids and study their properties.
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The Magarvey lab´s research includes Natural Product Biosynthesis & Drug Discovery, Microbial Metabolomics, Small molecule/chemical signaling.
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The Melancini lab is primarily interested in two main fields of research: the allosteric conformational switches that control signaling pathways and the early steps of amyloid fibril formation.
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Research in the Nodwell laboratory concerns the phenotypic responses of bacterial cells to antibiotics, intermolecular signals and other small molecules. These responses include antibiotic resistance, antibiotic biosynthesis and changes in developmental state.
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Joaquin Ortega´s Laboratory is studying the structure and dynamics of macromolecular machines that are responsible for vital cellular functions. Trainees in the Ortega Research group use cryo-electron microscopy to describe the structure of these subcellular assemblies that are either too large or too heterogeneous to be investigated using other structural techniques. Visit my Website

Michael Surette's Laboratory's primary area of research investigates the role of normal flora-pathogen interactions in health and disease in the area of respiratory infections with a focus in cystic fibrosis. A polymicrobial perspective on these infections has lead to identification of overlooked pathogens in airway disease as well as synergistic interactions between avirulent organisms and pathogens. This is a fundamentally different view of airway infections and has lead to direct benefits to patients through altered treatment strategies.
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Bernardo Trigatti´s Laboratory is investigating the molecular mechanisms involved in the development of atherosclerosis, with a particular focus on influence of the metabolism and cellular responses to high density lipoproteins. Trainees in the Trigatti Lab utilize molecular targeted genetic approaches in mouse model systems and cell biological tools to probe a variety of cellular pathways that impact lipoprotein metabolism and vascular remodeling.
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Our laboratory is interested in how proteins move throughout the cell's organelles in humans. We have successfully implemented and developed new tools to look at how proteins move within live cells. We are also interested in the discovery of new protein-protein interactions by biochemical methods in vitro, and analysing these interactions in living cells in vivo. We are currently focusing our research on a series of genetically inherited neurodegenerative diseases that all have one basic biochemical defect in common: CAG DNA sequences >36 repeats in the gene's open reading frame that translate to glutamine amino acid stretches in the disease protein. These diseases are collectively referred to as Polyglutamine expansion diseases.
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Geoff Werstuck´s Laboratory is searching for the molecular mechanisms that will explain why four out of five people with diabetes mellitus will die from heart attack or stroke. The lab uses a broad variety of strategies, from basic biochemistry to pre-clinical investigations, to identify potential therapeutic targets.
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The Wright lab is interested in several aspects of antibiotic chemical biology. These include mechanisms and evolution of antibiotic resistance elements through a process called Genomic Enzymology, new ways to overcome resistance, and determination of the mode of action of antibiotics and identification of new antimicrobial targets and agents. The latter includes manipulation of antibiotic biosynthetic genetic programs, high throughput screening methods, and natural product isolation.
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The Yang lab´s research includes protein crystallography, protein engineering, structure and function of anti-freeze, ice nucleation and bone proteins.
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Boris Zhorov´s Laboratory develops and applies computational methods to better understand structure and dynamics of ion channels. These transmembrane proteins play important roles in cell physiology. We simulate interactions of ion channels with toxins and medically important drugs and formulate hypotheses, which are tested in collaboration with experimentalists.
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