Health Research Methods, Evidence, and Impact

Hertzel C. Gerstein

MD (Toronto), MSc. (McMaster), DABIM, FRCPC

Population Health Institute Chair in Diabetes Research

Professor, Department of Medicine

Associate Member, Dept of Health Research Methods, Evidence, and Impact

Director, Division of Endocrinology & Metabolism

Head, Service of Endocrinology and Metabolism

Director, Diabetes Care and Research Program, Hamilton Health Sciences

Deputy Director, Population Health Research Institute

Associate Editor, ACP Journal Club

Member, Editorial Board, Journal of Diabetes

905.521.2100 x 73371

Faculty of Health Sciences
Health Sciences Centre, Room 3V38
1280 Main Street West
Hamilton, Ontario
L8S 4K1

Administrative Assistant: Diana McLeod
905.387.9711 x 73371

For more information on Dr. Gerstein, click here

Academic Interests

Dr. Hertzel C. Gerstein's academic interests include: a) using population health approaches to reduce the burden of diabetes in society and to prevent new diabetes; b) measuring the burden of diabetes in Canada; c) using epidemiologic approaches to study the relationship between dysglycemia, diabetes and cardiovascular disease; andd) clinical trials in the prevention & therapy of dysglycemia, diabetes and their consequences.

His research is funded by the US National Institutes of Health, the Canadian Institutes of Health Research, Heart & Stroke Foundation, and the Canadian Diabetes Association. Some of his current roles include  principal investigator (PI) of the ORIGIN trial, REWIND trial, and ACCORDION follow-up study of cardiovascular prevention in type 2 diabetes; chair of the REMIT trial assessing therapies to promote type 2 diabetes remission, coPI of the EpiDREAM study of dysglycemic & normoglycemic individuals.  

Current CE&B Graduate Students

Deepa Yoganathan

Selected Publications

  1. ORIGIN Trial Investigators (Gerstein HC, Bosch J et al). Basal insulin and cardiovascular and other health outcomes in dysglycemia. N Engl J Med 2012; 367:319-328. (PMID 22686416)
  2. ORIGIN Trial Investigators (Bosch J, Gerstein HC et al). n-3 fatty acids and cardiovascular outcomes in patients with dysglycemia. N Engl J Med 2012; 376:309-318. (PMID 22686415)
  3. Ramachandran A, et al. Relationship between A1C and fasting plasma glucose in dysglycemia or type 2 diabetes: analysis of baseline data from the ORIGIN trial. Diabetes Care 2012;35:749-53. (PMID 22323416)
  4. Punthakee Z, et al. Design, history and results of the Thiazolidinedione Intervention with vitamin D Evaluation (TIDE) randomised controlled trial. Diabetologia 2012;55:36-45. (PMID: 22038523)
  5. Punthakee Z, et al. Poor cognitive function and risk of severe hypoglycemia in type 2 diabetes: post hoc epidemiologic analysis of the ACCORD trial. Diabetes Care 2012; 35:787-793. (PMID 22374637)
  6. Nerenberg KA, et al. Piloting a Novel Algorithm for Glucose Control in the Coronary Care Unit: REsearching Coronary REduction by Appropriately Targeting Euglycemia trial. Diabetes Care. 2012; 35:19-24
  7. Anand SS, Dagenais GR, Mohan V, Diaz R, Probstfield J, Freeman R, Shaw J, Lanas F, Avezum A, Budaj A, Jung H, Desai D, Bosch J, Yusuf S, Gerstein HC. Glucose levels are associated with cardiovascular disease and death in an international cohort of normal glycaemic and dysglycaemic men and women: the EpiDREAM cohort study. Eur J Card Prev Rehab (Epub May 6, 2011)
  8. DREAM On (Diabetes Reduction Assessment with Ramipril and Rosiglitazone Medication Ongoing Follow-up) Investigators, Gerstein HC, Mohan V, Avezum A, Bergenstal RM, Chiasson JL, Garrido M, MacKinnon I, Rao PV, Zinman B, Jung H, Joldersma L, Bosch J, Yusuf S. Long-term effect of rosiglitazone and/or ramipril on the incidence of diabetes. Diabetologia. 2011;(3):487-95.
  9. Gerstein HC, Miller ME, Genuth S, Ismail-Beigi F, Buse JB, Goff DC Jr, Probstfield JL, Cushman WC, Ginsberg HN, Bigger JT, Grimm RH Jr, Byington RP, Rosenberg YD, Friedewald WT. Long-term effects of intensive glucose lowering on cardiovascular outcomes. N Engl J Med; 2011:364(9):818-28.
  10. Yakubovich N, Gerstein HC. Serious cardiovascular outcomes in diabetes: the role of hypoglycemia. Circulation. 2011;123(3):342-8. PMID: 21263007

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