Health Research Methods, Evidence, and Impact

Alfonso Iorio

MD (Perugia), PhD, FRCP(C)

Associate Professor, Department of Health Research Methods, Evidence, and Impact

Joint Member, Department of Medicine

Chief, Health Information Research Unit (HIRU)

Director, Hemophilia Clinic, McMaster University

Member, CLARITY (Clinical Advances through Research and Information Translation)

Member, GRADE Working Group

Associate Editor, Cystic Fybrosis and Genetic Disorders Group, Cochrane Collaboration; Internal and Emergency Medicine; Rare Diseases and Orphan Drugs - A Journal of Public Health

Editorial Board, Journal of Thrombosis and Haemostasis, Haemophilia, BMC Diagnostic and Prognostic Research

Committee membership, Data and Demographics Committee, World Federation of Hemophilia (Chair); CHARMS and inhibitors committee, AHCDC (Chair); Guideline oversight Committee, ASH (member); Guideline Committee, ACP (member)

905.525.9140 x 22421

McMaster University
1280 Main Street West
Hamilton, Ontario, Canada
L8S 4K1

Administrative Assistant: Linda Sheridan
905.525.9140 x 20152

Academic Interests

The Health Information Research Unit (HiRU), founded by Brian Haynes, is a knowledge refinery, which main activity is maintaining the McMaster Premium LiteratUre Service (McMaster PLUS), a second-order peer review database of methodologically sound, clinically relevant and newsworthy peer reviewed publications. McPLUS is used for many scopes, among which providing papers for abstraction in the American College of Physician Journal Club monthly issue of Annals of Internal Medicine, and providing discipline specific news feeds via the BMJ sponsored Evidence Updates service. The HiRU has created the Clinical Query filters available on the PubMed search engine. HiRU is open to consider any form of collaboration with any commercial, academic or non-for organization aiming at disseminating high quality evidence. For further details on the HiRU’s knowledge translation research program see:

The clinical research program is centered on the application of information technology to the optimization of the clinical management of rare bleeding disorders. The McMaster Hemophilia Research Program, based and partly supported by the Michael de Groote School of Medicine, runs a worldwide epidemiology and pharmaco-epidemiology research program based on the following infrastructure: a) the Canadian Bleeding Disorder Registry (CBDR), supporting clinical activities of all bleeding disorder centers in Canada and feeding a central anonymized data repository; b) the Canadian Hemophilia Surveillance System (CHESS), providing real time detection of treatment adverse effects, including the development of inhbitors to factor VIII concentrates (the project is harmonized with the European Haemophilia Surveillance System, EUHASS); c) the Web-available Population Pharmacokinetic Service (WAPPS) and research network, covering 20 countries and over 40 centers, providing easy availability of producing PopPK estimates at the point of care for all available factor concentrates; d) the Patient Reported Outcome, Burden and Experiences (PROBE), a newly developed multilingual assessment tool and research network aiming at generating robust comparative effectiveness data. For furher detailas see:

Past Students
Luxme Mahendira
Irum Rizwani
Juan Manuel Reyes
Maura Marcucci (HRM MSc)
Davide Matino
Mengchen Xi
Anand Jacob (e-health MSc)
Abha Athale (HRM MSc)
Islam Barghlash (eHeatlh MSc)

Current Graduate Students
Cindy Yeung (HRM MSc)
Davide Matino (HRM MSc)
Chatree Chai-Adisaksopha (HRM PhD)        

He currently accepts Graduate Students.

  1. Matino D, Gargaro M, Santagostino E, Di Minno MN, Castaman G, Morfini M, Rocino A, Mancuso ME, Di Minno G, Coppola A, Talesa VN, Volpi C, Vacca C, Orabona C, Iannitti R, Mazzucconi MG, Santoro C, Tosti A, Chiappalupi S, Sorci G, Tagariello G, Belvini D, Radossi P, Landolfi R, Fuchs D, Boon L, Pirro M, Marchesini E, Grohmann U, Puccetti P, Iorio A, Fallarino F. IDO1 suppresses inhibitor development in hemophilia A treated with factor VIII. J Clin Invest. 2015 Oct 1;125(10):376681. doi: 10.1172/JCI81859. Epub 2015 Aug 31. PMID: 26426076
  2. Marcucci M, Skjøth F, Lip GY, Iorio A. Larsen TB. A decisional model to individualize warfarin recommendations: Expected impact on treatment and outcome rates in real-world population with atrial fibrillation. Int J Cardiol. 2015 Nov 6;203:785-790. Doi: 10.1016/j.ijcard.2015.11.035 PMID: 26595784
  3. A Iorio, FA Spencer, M Falavigna, C Alba, E Lang, B Burnand, McGinn, J Hayden, K Williams, B Shea, R Wolff, T Kujpers, P Perel, PO Vandvik, P Glasziou, H Schunemann, G Guyatt. Use of GRADE for assessment of evidence about prognosis: rating confidence in estimates of event rates in broad categories of patients. BMJ 2015;350:h870. doi: 10.1136/bmj.h870. No abstract available. PMID: 25775931
  4. Marcucci M, Iorio A, Douketis JD, Eichinger S, Tosetto A, Baglin T, Cushman M, Palareti G, Poli D, Tait RC, Kyrle PA. Risk of recurrence after a first unprovoked venous thromboembolism: external validation of the Vienna Prediction Model with pooled individual patient data. Thromb Haemost. 2015 May;13(5):77581. doi: 10.1111/jth.12871. Epub 2015 Mar 12. PMID: 25660555.
  5. Nieuwlaat R, Wilczynski N, Navarro T, Hobson N, Jeffery R, Keepanasseril A, Agoritsas T, Mistry N, Iorio A, Jack S, Sivaramalingam B, Iserman E, Mustafa RA, Jedraszewski D, Cotoi C, Haynes RB. Interventions for enhancing medication adherence. Cochrane Database Syst Rev. 2014 Nov 20;11:CD000011. doi: 10.1002/14651858.CD000011.pub4. PubMed PMID: 25412402.
  6. Cohen AM, Demner-Fushman D, Iorio A, Sim I, Smalheiser NR. Tools for Identifying Reliable Evidence and Implementing it in Everyday Clinical Care. AMIA Summits Transl Sci Proc. 2013 Mar 18;2013:42-4. eCollection 2013. PubMed PMID: 24303233; PubMed Central PMCID: PMC3845785.
  7. Xi M, Makris M, Marcucci M, Santagostino E, Mannucci PM, Iorio A. Inhibitor development in previously treated hemophilia A patients: a systematic review, meta-analysis, and meta-regression. J Thromb Haemost. 2013 Sep;11(9):1655-62. doi: 10.1111/jth.12335. PubMed PMID: 23802542.
  8. Spencer FA, Iorio A, You J, Murad MH, Schünemann HJ, Vandvik PO, Crowther MA, Pottie K, Lang ES, Meerpohl JJ, Falck-Ytter Y, Alonso-Coello P, Guyatt GH. Uncertainties in baseline risk estimates and confidence in treatment effects. BMJ. 2012 Nov 14;345:e7401.
  9. Don-Wauchope AC, Sievenpiper JL, Hill SA, Iorio A. Applicability of the AGREE II instrument in evaluating the development process and quality of current National Academy of Clinical Biochemistry guidelines. Clin Chem. 2012 Oct;58(10):1426-37.
  10. Iorio A, Kearon C, Filippucci E, Marcucci M, Macura A, Pengo V, Siragusa S, Palareti G. Risk of recurrence after a first episode of symptomatic venous thromboembolism provoked by a transient risk factor: a systematic review. Arch Intern Med. 2010 Oct 25;170(19):1710-6.

Selected Publications

Search for citations for Dr. Iorio on PubMed