MacOrtho is pleased to announce the new MacOrtho grants received over the past week. The following studies have received grants:
Femoroacetabular Impingement RandomiSed Controlled Trial with an Embedded ProspectIve Cohort (FIRST-EPIC)
Funding agency: MSA Innovation grant 2015
Principal Investigator: Olufemi Ayeni
Co-Investigator: Mohit Bhandari
Amount funded: $29,996.96
Summary: Femoroacetabular impingement (FAI) is a condition of the hip where there is a mismatch of the femoral head (ball) and hip acetabulum (socket). This mismatch creates abnormal contact between the bones and causes hip pain which can lead to damage and eventually osteoarthritis of the hip. Surgical treatment aims to correct the morphology of the hip joint by trimming down the bone causing the impingement. Hip arthroscopy (minimally invasive surgical technique) is arguably the most rapidly growing field in orthopaedic surgery and as a treatment for FAI. Some estimates suggest that the rate of hip arthroscopy procedures will double over a 5 year span (from 30,000 to 70,000 annually), resulting in a corresponding increase in health care costs. There is a need to pragmatically evaluate the outcomes of this surgical approach. Following the success of our pilot study, we have initiated the definitive phase of the Femoroacetabular Impingement RandomiSed controlled Trial (FIRST). MSA funded our proposed external validation cohort using a “RCT with and Embedded ProspectIve Cohort design” during the definitive trial phase (FIRST-EPIC). This cohort arm will allow us to determine the true effectiveness and cost-effectiveness of the trial interventions.
Collaborative prospective research in rare cancers: A qualitative study to determine factors that drive a paradigm shift in the research landscape
Funding agency: MSA Innovation grant 2015
Principal Investigator: Michelle Ghert
Amount funded: $19,659.00
Summary: Bone sarcomas are rare cancers treated in specialty tertiary care centers. Patient-centered research to improve clinical care for bone cancer patients has been impeded by a lack of collaboration in the surgical field treating these patients (orthopaedic oncology). However, a recent randomized controlled trial initiated at McMaster University (www.PARITYtrial.com) has generated collaboration among 63 hospitals across 17 countries and 6 continents. The reason for this massive shift in orthopaedic oncology research philosophies is of great interest and importance to future research. In this study, we will use established qualitative research methods and PARITY network focus groups to identify incentives, facilitators and barriers to prospective collaborative research in sarcoma surgical care. The knowledge gained from this study will guide study design and future large-scale collaborative research development for rare cancers such as bone sarcomas.
Distractions on the Road: Injury eValuation in Surgery And FracturE clinics (DRIVSAFE)
Funding agency: Physicians Services Incorporated – Resident Research Grant
Principal Investigators: Harman Chaudhry and Bill Ristevski
Co-Investigators: Mohit Bhandari, Brad Petrisor, Sheila Sprague, Dale Williams
Amount funded: $20,000.00
Summary: Distracted driving is any activity that diverts drivers’ attention away from the primary task of driving. Previous research suggests that distracted driving is a factor in approximately 4 million road traffic collisions annually in North America. However, the prevalence is likely underreported given that data are often obtained from police and hospital reports. In order to assess the burden of distracted driving on musculoskeletal injuries, the DRIVSAFE study will administer questionnaires to 1315 patients who present to a local Ontario fracture clinic. Specifically, the DRIVSAFE study will determine: 1) the prevalence of patients who present to a local fracture clinic with an injury that is the direct or indirect result of distracted driving; and 2) the prevalence and severity of various types of musculoskeletal injuries sustained as a direct or indirect result of distracted driving. Additionally, the questionnaire will explore reasons that participants are attending the fracture clinic (e.g. type(s), severity, and cause of injury). It will also collect information about participants’ opinions and experiences with distracted driving. For participants who are attending the fracture clinic due to an injury from a road traffic collision, the questionnaire also queries participants about whether distracted driving played a role in their injury.
Prospective Abuse and Intimate Partner Violence Surgical Evaluation (PRAISE-2): An Ontario-based Multi-Centre Prospective Cohort Study
Funding agency: Physicians Services Incorporated – Health Research Grant
Principal Investigator: Brad Petrisor
Co-Principal Investigator: Sheila Sprague
Co-Investigators: Mohit Bhandari, Emil Schemitsch, Diana Tikasz, Clare Freeman
Project Manager: Kim Madden
Amount funded: $156,500.00
Summary: Every six days a woman in Canada is killed by her intimate partner. Intimate partner violence (IPV), also known as domestic abuse, is a leading cause of non-fatal injury in women worldwide. The cost of IPV in Canada is estimated at $5 billion annually. We recently completed a large, cross-sectional study of 2945 women (PRAISE) identifying 1 in 6 women attending surgical fracture clinics as self-reporting a history of IPV in the past year (Lancet, 2013). Given the high prevalence and costs associated with IPV, there is a need to identify health outcomes associated with IPV, the incidence of new and worsening cases of IPV, and resource use among IPV victims. Building upon the success of PRAISE and the importance of collecting follow up outcomes on injured women, we will conduct a prospective cohort study of 100 women with musculoskeletal injuries to assess differences in injury-related outcomes (time to fracture healing, injury-related complications, and return to pre-injury function) between abused and non-abused women. This study will also determine whether a musculoskeletal injury can lead to new or worsening abuse by an intimate partner and how patterns of IPV change over time following musculoskeletal injuries. We will also examine changes and differences in quality of life and utilization of support services and associated costs between abused and non-abused women. Finally, our proposed study will also inform the feasibility of a larger multinational cohort study.