McMaster University

McMaster University

Role of TWIST in Angiogenesis and Cell Migration in Giant Cell Tumor of Bone

We are pleased to share with you a recent publication in Advances in Biology. This publication is entitled "The Role of TWIST in Angiogenesis and Cell Migration in Giant Cell Tumor of Bone".

Find the abstract below and here to access the full-version of the article.

Shalini Singh, Isabella W. Y. Mak, Divya Handa, and Michelle Ghert, “The Role of TWIST in Angiogenesis and Cell Migration in Giant Cell Tumor of Bone,” Advances in Biology, vol. 2014, Article ID 903259, 8 pages, 2014.

Abstract

Giant cell tumor of bone (GCT) is a bone tumor consisting of numerous multinucleated osteoclastic giant cells involved in bone resorption and neoplastic osteoblast-like stromal cells responsible for tumor growth. The tumor occasionally metastasizes to the lung; however, factors leading to metastasis in this tumor are unknown. The TWIST-1 protein (also referred to as TWIST) has been suggested to be involved in epithelial-mesenchymal transition (EMT) and tumor progression in some cancers. In this study we investigated the functional role of TWIST in GCT cell angiogenesis and migration. Overexpression of TWIST in neoplastic GCT stromal cells significantly increased mRNA and protein expression of VEGF and VEGFR1 in vitro, whereas knockdown of TWIST resulted in decreased VEGF and VEGFR1 expression. A stable cell line with TWIST overexpression resulted in features of EMT including increased cell migration and downregulation of E-cadherin. The results of our study indicate that TWIST may play an important role in angiogenesis and cell migration in GCT.

 

Valid XHTML 1.0 Transitional Level Double-A conformance, W3C WAI Web Content Accessibility Guidelines 2.0