McMaster University

McMaster University

Canadian Medical Association Journal Highlights MacOrtho!

Published: February 29, 2016
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The Canadian Medical Association Journal (CMAJ) highlighted recent MacOrtho research in a commentary this week, entitled 'Arthroplasty and postoperative antimicrobial prophylaxis’. They discussed the findings of a recent meta-analysis by Patrick Thornley et al., which concluded that the available evidence does not show efficacy of postoperative antibiotic prophylaxis for the prevention of surgical-site infections in patients undergoing total hip or knee arthroplasty.

View the commentary at: http://www.cmaj.ca/content/188/4/243?etoc

View the original article at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596117/pdf/cmajo.20150012.pdf

Thornley P, Evaniew N, Riediger M, Winemaker M, Bhandari M, Ghert M. Postoperative antibiotic prophylaxis in total hip and knee arthroplasty: a systematic review and meta-analysis of randomized controlled trials. CMAJ Open. 2015 Jul 17;3(3):E338-43. doi: 10.9778/cmajo.20150012.

BACKGROUND:
Postoperative antibiotic prophylaxis is currently the standard of care for patients undergoing total hip and knee arthroplasty. We evaluated the evidence for this practice in the reduction of surgical-site infections.

METHODS:
We systematically searched MEDLINE, Embase and the Cochrane Library for randomized controlled trials (RCTs) published up to Aug. 15, 2014. We included all RCTs that compared postoperative antibiotic prophylaxis with postoperative placebo or no treatment in patients undergoing primary total hip or knee arthroplasty for osteoarthritis. We combined outcomes for surgical-site infection using a random-effects model and quantified heterogeneity using the χ2 test and the I2 statistic. We assessed the overall quality of the evidence according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.

RESULTS:
We identified 4 RCTs (n = 4036) that met the inclusion criteria. Surgical-site infections occurred in 3.1% (63/2055) of patients in the prophylaxis group and 2.3% (45/1981) in the control group. Postoperative prophylaxis did not reduce the rate of surgical-site infections compared with placebo (risk difference 0.01, 95% confidence interval 0.00 to 0.02; I2 = 26%). This result was robust to sensitivity testing for losses to follow-up. According to the GRADE approach, the overall quality of evidence was very low.

INTERPRETATION:
The available evidence did not show efficacy of postoperative antibiotic prophylaxis for the prevention of surgical-site infections in patients undergoing total hip or knee arthroplasty. Multicentred RCTs are likely to have an important impact on the confidence in the effect estimate and to change the estimate itself.

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