McMaster University

McMaster University

Issues with the use of Comparators in Orthopaedic Surgery RCTs

We are pleased to share with you a recent publication in the Journal of Long-Term Effects of Medical Implants.. This publication is entitled "Ethical and methodological issues surrounding the use of appropriate comparators in orthopaedic surgery randomized controlled trials".

Full-version of the article not available.

Hak A, Evaniew N, Bhandari M. Ethical and methodological issues surrounding the use of appropriate comparators in orthopaedic surgery randomized controlled trials. Journal of Long-Term Effects of Medical Implants. 2015. 25(3):215-223

Abstract

Although randomized controlled trials (RCTs) have the ability to provide researchers with more concrete evidence than that of their nonrandomized counterparts, conducting an RCT brings with it many ethical and methodological considerations. It is understood that in order to progress knowledge, and create new knowledge to benefit future patients, research must include human subjects; however, the desire to further knowledge must be placed second to the safety and respect for trial participants. An important ethical and methodological step in the design of any trial once the intervention is established is the selection of the comparator treatment. This is especially a topic of interest in orthopaedic surgery trials, in which a placebo comparator is not always possible and, arguably, sometimes never ethical. We review the use of different comparators in the treatment of orthopaedic surgery injuries and conditions, taking into consideration methodological and ethical issues. Comparators assessed are established treatments, standard-of-care treatments, conservative treatments, placebos, and sham surgeries.


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