McMaster University

McMaster University

Lost In Translation: Animal Models and Clinical Trials in Cancer Treatment.

MacOrtho is pleased to announce the most recent publication in the American Journal of Translation Research. This publication is entitled “ Lost in translation: animal models and clinical trials in cancer treatment”

To read more, click here to access the full-version of the article.

Mak IW, Evaniew N, Ghert M. Lost in translation: animal models and clinical trials in cancer treatment. Am J Transl Res. 2014 Jan 15;6(2):114-118. eCollection 2014.


Due to practical and ethical concerns associated with human experimentation, animal models have been essential in cancer research. However, the average rate of successful translation from animal models to clinical cancer trials is less than 8%. Animal models are limited in their ability to mimic the extremely complex process of human carcinogenesis, physiology and progression. Therefore the safety and efficacy identified in animal studies is generally not translated to human trials. Animal models can serve as an important source of in vivo information, but alternative translational approaches have emerged that may eventually replace the link between in vitro studies and clinical applications. This review summarizes the current state of animal model.

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