(Picture above from left to right: Dr. Mohit Bhandari, Dr. Michelle Ghert, Dr. Brad Petrisor, Dr. Bill Ristevski, Dr. Gerard Slobogean, Dr. Sheila Sprague, Dr. Dale Williams)
MacOrtho is pleased to announce the new MacOrtho grants received over the past week. The following studies have received grants:
A Pilot Study to Inform a Randomized Controlled Trial Evaluating the Efficacy of Vitamin D Supplementation on Fracture Healing Outcomes in the Management of Acute Lower Extremity Long Bone Fractures
Funding agency: MSA Clinical Grant 2016
Principal Investigator: Brad Petrisor
Summary: Injuries to bone and muscle occur in over 60% of trauma victims, and lower extremity fractures are the most devastating. Femur and tibia shaft fractures are among the most common lower extremity fractures and have prolonged healing times and high rates of fracture healing complications. While surgeons continue to seek advances in surgical technique, it is becoming increasingly obvious that a new surgical procedure or implant is unlikely to solve this clinical problem. As a result, additional biologic therapies, such as vitamin D, are being considered to augment the care of these difficult fractures. However, our recent work has shown a lack of practitioner consensus concerning if vitamin D is prescribed, as well as the dose and the duration. We propose a 3-arm pilot study in 60 patients to inform the selection of the vitamin D3 dose and assess feasibility of a large, multi-national randomized controlled trial to evaluate the effect of vitamin D3 supplementation on fracture healing outcomes in patients who have sustained a tibia or femur fracture. Participants will be randomized one of 3 dosing regimens: 1) 150,000 IU loading dose within one week and at 6 weeks post-fracture, 2) 4,000 IU daily dose, or 3) 600 IU daily dose. The daily supplementation will be taken for 6 months. Participants will be followed for these 6 months and clinical outcomes will be measured at baseline, one week, 6 weeks, 3 months, and 6 months post-fracture. If the patient’s fracture has not healed by 6 months, follow-up will continue until fracture healing. The primary outcome for the pilot study is feasibility. The clinical outcomes for both the pilot and the definitive trial include fracture healing complications, health-related quality of life, physical function, radiographic fracture healing, vitamin D blood serum levels, and adverse events. Identifying the optimal vitamin D supplementation strategy for young lower extremity fractures has enormous potential to improve the lives of thousands of individuals who suffer these debilitating injuries each year.
Moving Forward Through Consensus – A Modified Delphi Approach to Determine Top Research Priorities in the Field of Musculoskeletal Oncology’
Funding agency: MSA Innovation Grant 2016
Principal Investigator: Michelle Ghert
Summary: This grant will help to plan a comprehensive orthopaedic oncology research program. Orthopaedic oncology researchers face several challenges, including finite fiscal resources to support the rising costs of clinical research and insufficient patient volume at individual sites. As a result, high-quality research to guide clinical practice has lagged behind other surgical subspecialties. Using a valid consensus method, the aim of this initiative is to develop a feasible and clinically relevant consensus-based research agenda. This planning initiative is just one component of a broader strategy to facilitate rigorous clinical research directed at solving high-impact questions in the care of sarcoma patients.
Using EEG to Measure Mind Wandering: A Stepping-stone to More Effective Teaching in Medical Education
Funding agency: MSA Education Research Grant 2016
Principal Investigators: Brad Petrisor