McMaster University

McMaster University

Systematic review of active treatment options for desmoid tumours

We are pleased to share with you a recent publication in Current Oncology. This publication is entitled "A systematic review of active treatment options in patients with desmoid tumours".

Find the abstract below and click here to access the full-version of the article.

Yao X, Corbett T, Gupta AA, Kandel RA, Verma S, Werier J, Ghert M. A systematic review of active treatment options in patients with desmoid tumours. Curr Oncol. 2014 Aug;21(4):e613-29.

Abstract

INTRODUCTION:
We conducted a systematic review to determine the optimal treatment options in patients with desmoid tumours who have declined observational management.

METHODS:
A search was conducted of the medline and embase databases (1990 to September 2012), the Cochrane Library, and relevant guideline Web sites and conference materials.

RESULTS:
One systematic review and forty-six studies met the preplanned study selection criteria; data from twenty-eight articles were extracted and analyzed. For local control, three studies reported a statistically significant difference in favour of surgery plus radiotherapy (rt) compared with surgery alone, and one study did not; two studies reported the lack of a statistical difference between surgery plus rt and rt alone in maintaining local control. Multivariate risk factors for local recurrence included positive surgical margins and young patient age. Single-agent imatinib led to a progression-free survival rate of 55% at 2 years and 58% at 3 years. Methotrexate plus vinblastine led to a progression-free survival rate of 67% at 10 years. Significant toxicities were reported for all treatment modalities, including surgical morbidity, and rt- and chemotherapy-related toxicities.

CONCLUSIONS:
In patients who have declined observational management, the local control rate was higher with surgery plus rt than with surgery alone. However, the additional rt-related complications should be considered in treatment decision-making. Surgery, rt, and systemic therapy are all reasonable treatment options for patients with desmoid tumours.

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