A new study led by researchers from McMaster University has shown that, while relatively rare in the general population, there are a large number of varied, genetic syndromes associated with obesity.
Previous reviews on obesity have reported 20 to 30 syndromes, but in the first systematic review on obesity syndromes, investigators from McMaster and the University of British Columbia have catalogued 79 syndromes with obesity that have been described in the literature. The research was published today in Obesity Reviews and led by David Meyre, an associate professor of the Department of Health Research Methods, Evidence, and Impact with the Michael G. DeGroote School of Medicine.
"Rare genetic forms of obesity with many additional clinical features, such as intellectual disability, facial and organ-specific abnormalities, do exist," said Meyre, the senior author of the paper who holds the Canada Research Chair in Genetics of Obesity.
McMaster University researchers have discovered that while survivors of childhood brain tumours have a similar Body Mass Index (BMI) to healthy children with no cancer, they have more fat tissue overall, and especially around the abdomen.
Brain tumors are the most common cause of cancer-related deaths in children, and are the second most common type of cancers in children. Over the past few years, advances in cancer therapy have resulted in an increasing number of children who survive their diagnosis of brain tumors.
However, this improved survival is offset by their high risk of several comorbid conditions and early death. More recently, there is evidence that these survivors are developing heart disease, stroke and Type 2 diabetes relatively early in life, which may contribute to poor outcomes and early death. The risk factors for these outcomes have not been thoroughly investigated.
By Matt Terry, March 17, 2017
Two McMaster students will spend the summer learning about the relationship between culture and identity in five different countries around the world.
Medical student Kira Gossack-Keenan will travel to India, Cambodia and Vietnam to find out how the region's inhabitants relate to and interact with those with physical disabilities. She'll also study the relationship between disability and art, while producing some artistic works of her own along the way.
"We're not perfect in Canada, but we try to incorporate accommodation into many of the things we do," says Gossack-Keenan. "In many countries, access to the physical environment continues to be less accessible to those with disabilities, and I'd like to explore this issue."