Division of Endocrinology & Metabolism

Gregory Steinberg

 

Associate Professor, Division of Endocrinology, Department of Medicine

Canada Research Chair in Metabolism, Obesity and Type 2 Diabetes

 

 

Education and Professional Standing

Dr. Steinberg obtained his PhD in 2002 from the University of Guelph.   His research thesis was conducted in the laboratory of Professor David Dyck where he studied the regulation of metabolism in muscle by the hormone leptin.  From 2002-2006, Dr. Steinberg conducted Postdoctoral Research in the laboratory of  Professor Bruce Kemp at St. Vincent’s Institute of Medical Research in Melbourne, Australia.  During this time he gained insight into protein biochemistry and molecular biology with an emphasis on the metabolic stress sensing protein kinase AMPK.  In 2006, Dr. Steinberg became Head of the Metabolism Unit at St. Vincent’s Institute of Medical Research and a Senior Fellow of the National Health and Medical Research Council of Australia.   In 2009, Dr. Steinberg returned to Canada and joined the Department of Medicine, Endocrinology and Metabolism Division as an Associate Professor and Canada Research Chair.  His laboratory is currently funded by grants from CFI, CIHR, CDA and NSERC. 

Selected Publications

  • Galic S, Fullerton MD, Schertzer JD, Sikkema S, Marcinko K, Honeyman J, Walkley CR, Chen Z-P, van Denderen BJ, Kemp BE,Steinberg GR.  Hematopoietic AMPK β1 prevents inflammation and hepatic insulin resistance in obesity.  Journal of Clinical Investigation. 121(12):4903-15, 2011.
    http://www.jci.org/articles/view/58577

  • O’Neill H, Maarbjerg S, Crane J, Jeppesen J, Jørgensen SB, Shyroka O, Schertzer J.D., vanDenderen BJ, Kiens, B., Tarnopolsky MA., Kemp BE, Richter EA, Steinberg GR. AMPK β1β2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise.  Proceedings of the National Academy of Sciences.  108(38):16092-7, 2011.
    http://www.pnas.org/content/108/38/16092.long

  • Steinberg GR and Kemp BE.  AMPK in Health and Disease.  Physiological Reviews. 89(3):1025-78, 2009.  http://physrev.physiology.org/content/89/3/1025.long

  • Steinberg GR, Michell BJ, van Denderen BJW, Watt MJ, Carey AL, Fam BC, Andrikopoulos S, Proietto J, Gorgun CZ, Carling D, Hotamisligil GS, Febbraio MA, Kay TW, Kemp BE.  Tumor necrosis factor a induced skeletal muscle insulin resistance involves the suppression of AMP-kinase signaling.  Cell Metabolism. 4(6):465-74, 2006.
    http://www.sciencedirect.com/science/article/pii/S1550413106003676

  • Watt MJ, Dzamko N, Thomas WG, Rose-John S, Ernst M, Carling D, Kemp BE, Febbraio MA, and Steinberg GR. CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK. Nature Medicine, 12:541-548.2006.
    http://www.nature.com/nm/journal/v12/n5/full/nm1383.html