Michael Cyr


Associate Clinical Professor, Division of Clinical Immunology & Allergy

Staff Physician, Hamilton Health Sciences



Education and Professional Standing

Research Interests

Dr. Cyr has recently completed the Royal College of Physicians and Surgeons' Clinician-Investigator program studying cord blood stem cells as markers of atopic risk. His research has explored novel immune mechanisms which may explain the epidemiological observations underlying the "hygiene hypothesis". His future directions include ongoing study of the immune mechanisms for atopic development particularly through the use of birth cohorts. His research has been generously funded through grants from CIHR/Merck Frosst through the Canadian Allergy, Asthma, and Immunology Foundation and through a McMaster Department of Medicine Internal Career Award.

Activities and Contributions

Dr. Cyr is a practicing clinician-investigator at McMaster University. His clinical practice includes a wide spectrum of allergy and immunology including asthma, atopic dermatitis, food allergy, primary immunodeficiency, and autoimmune diseases such as lupus; his patient population includes both adults and children. He also works in general internal medicine. Through his clinical practice, he supervises learners of various levels including medical students, pediatric and internal medicine residents as well as allergy and clinical immunology fellows.

Selected Publications

  1. Cyr,M.M. and Denburg,J.A., Systemic aspects of allergic disease: the role of the bone marrow. Curr.Opin.Immunol. 13, 727-732, 2001.
  2. Saito,H., Morikawa,H., Howie,K., Crawford,L., Baatjes,A.J., Denburg,E., Cyr,M.M., and Denburg,J.A., Effects of a cysteinyl leukotriene receptor antagonist on eosinophil recruitment in experimental allergic rhinitis. Immunology 113, 246-252, 2004.
  3. Cyr, M. M., Hatfield, H. M., Dunstan, J. A., Prescott, S. L., Holt, P. G., and Denburg, J. A. Relationship of maternal skin test responses to infant cord-blood progenitor cytokine receptor expression. J Allergy Clin.Immunol 113(2), S162. 2004.
  4. Denburg,J.A., Hatfield,H.M., Cyr,M.M., Hayes,L., Holt,P.G., Sehmi,R., Dunstan,J.A., and Prescott,S.L., Fish oil supplementation in pregnancy modifies neonatal progenitors at birth in infants at risk of atopy. Pediatr.Res. 57, 276-281, 2005.