Anne Holbrook

MD, PharmD, MSc, FRCP(C)

Director, Division of Clinical Pharmacology and Toxicology

Professor, Division of Clinical Pharmacology and Toxicology, Department of Medicine

Active Medical Staff, Hamilton Health Sciences and St Joseph 's Healthcare Hamilton

Senior Scientist, Center for Evaluation of Medicines



Education and Professional Standing

Dr Holbrook is the Director of the Division of Clinical Pharmacology, Department of Medicine, McMaster University; Professor, Department of Medicine, McMaster University and Senior Scientist, Centre for Evaluation of Medicines, St. Joseph's Healthcare Hamilton. She trained in clinical pharmacy, clinical pharmacology, medicine, internal medicine and clinical epidemiology at the University of Toronto, Philadelphia College, McGill University and McMaster University.

She is an Active Medical Staff member of Hamilton Health Sciences and St Joseph 's Healthcare Hamilton, leading an internal medicine and clinical pharmacology teaching service specializing in the management of complex, hospitalized adults with multiple diagnoses, multiple medications, drug-related harms or intolerances, or medication access issues.

She is one of the most senior drug policy expert advisors in the country, having advised governments and public payers at the federal, provincial and regional levels for several decades on comparative effectiveness, safety and cost-effectiveness of medications. Decisions taken currently influence more than $10 billion worth of medication expenditures annually.

Research Interests

Dr. Holbrook's main research area is evidence-based therapeutics, with current or recent studies on personalizing benefit:harm information for individual patients, cost-related nonadherence, patient preferences for high impact drugs using decision aids, evaluation of ePrescribing interfaces and quality of prescribing, randomized trials of computerized decision support, study of drug use, outcomes and interactions using large administrative health databases, use of systematic review and GRADEPRo to inform clinical practice guidelines.

She is the recipient of a Career Investigator award from the Canadian Institutes for Health Research for innovation in decision-making for patients, practitioners, and policy makers. She remains the Prinicipal Investigator of Canada's original electronic medical record research network (COMPETE) which develops, implements, and evaluates various e-health initiatives directed at improving the quality of therapeutics.

Selected Publications

  1. Holbrook A, Schulman S, Witt DM, Vandvik PO, Fish J, Kovacs MJ, Svensson PJ, Veenstra DL, Crowther M, Guyatt GH. Evidence-Based Management of Anticoagulant Therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012;141;e152S-e184S.
  2. Qayyum F, Wright M, Lee M, Leung C, Sada A, Holbrook A. Medical student opinions on their training in Clinical Pharmacology and Toxicology. McMaster University Medical Journal 2012:9(1):4-8.
  3. Holbrook A, Goldsmith C, Leung M. (2008). Placebos. In: Wiley Encyclopedia of Clinical Trials, John Wiley & Sons Inc, .eOCT984.
  4. Randolph A, Holbrook A, Haynes B, Cook D, Guyatt G. Clinical Decision Support Systems In: Guyatt G, Rennie D et al (eds). Users' Guides to the Medical Literature. Essentials of evidence-based clinical practice. 2nd Edition. JAMA Evidence 2008;193-208.
  5. O'Reilly D,Holbrook A, Blackhouse G, Troyan S, Goeree R. Cost-Effectiveness of a Shared Computerized Decision Support System for Diabetes Linked to Electronic Medical Records. J Am Med Inform Association. J Am Med Inform Assoc (2011) doi:10.1136/amiajnl-2011-00037.
  6. Holbrook A, Pullenayegum E, Thabane L, Troyan S, Foster G, Keshavjee K, Chan D, Dolovich L, Gerstein H, Demers C, Curnew G. Shared Electronic Vascular Risk Decision Support in Primary Care: Computerization of Medical Practices for the Enhancement of Therapeutic Effectiveness (COMPETE III) Randomized Trial. Arch Intern Med 2011;171(19):1736-1744.
  7. Hemens BJ, Holbrook AM, Tonkin M, Mackay J.A, Weise-Kelly L, Wilczynski NL, CCDSS Systematic Review Team. Computerized clinical decision support systems for drug prescribing and management: A decision-maker-researcher partnership systematic review. Implementation Science 2011;6:89
  8. Holbrook A, Wright M, Sung M, Ribic C, Baker S. Statin-Associated Rhabdomyolysis: Is There a Dose-Response Relationship? Canadian Journal of Cardiology 2011;27:146-151
  9. Ye C, Giangregorio L, Holbrook A, Pullenayegum E, Goldsmith C, Thabane L. Data Withdrawal in Randomized Controlled Trials: Defining the Problem and Proposing Solutions. Contemporary Clinical Trials. 2011:32(3):318-22.
  10. Holbrook A, Perera G, Thabane L, Foster G, Willison D. Views on Health Information Sharing and Privacy from Primary Care Practices Using Electronic Medical Records. International Journal of Medical Informatics 2011;80:94-101.
  11. Wong K, Yu S, Holbrook A. A systematic Review of Medication Safety Outcomes Related to Drug Interaction Software. J Popul Ther Clin Pharmacol 2010;17(2):e243-e255.
  12. Arkinson J, Holbrook A, Wiercioch W. Public Perceptions of Physician-Pharmaceutical Industry Interactions: A Systematic Review. Healthcare Policy 2010;5(4):69-89.