Mitchell Levine


Professor, Division of Clinical Pharmacology and Toxicology, Department of Clinical Epidemiology and Biostatistics, Department of Medicine

Active Staff, St. Joseph's Healthcare Hamilton

Director, Centre for Evaluation of Medicines, Father Sean O'Sullivan Research Centre, St. Joseph's Healthcare Hamilton



Education and Professional Standing

Mitchell Levine received his medical degree from the University of Calgary in 1979, which was followed by postgraduate training in Internal Medicine (FRCPC) and Clinical Pharmacology at the University of Toronto (1981-87). He received an MSc degree in Clinical Epidemiology from McMaster University in 1988.

Mitchell Levine is the Director of the Centre for Evaluation of Medicines, Father Sean O’Sullivan Research Centre, St. Joseph’s Hospital, Hamilton, Ontario and holds the position of Professor at McMaster University in the Department of Clinical Epidemiology & Biostatistics and the Department of Medicine. He is a consultant physician in Internal Medicine and Clinical Pharmacology at St. Joseph’s Hospital and the Hamilton Health Sciences Corporation in Hamilton.

Mitchell currently serves as a pharmacoeconomic consultant to the Drug Quality and Therapeutics Committee (DQTC) of the Ministry of Health of Ontario and is a former member and chair of the DQTC. He is a member of the Advisory Committee on Management for the Therapeutics Product Directorate at Health Canada and the Patented Medicine Prices Review Board's Human Drug Advisory Panel. He is the Editor-in-Chief for the Canadian Journal of Clinical Pharmacology and is an Associate Editor for the ACP Journal Club and Evidence-Based Medicine.

Research Interests

Assessing prescription drug use in the community and developing methods for promoting cost-effective use of drug therapy are Mitchell’s principal research interests. This involves collecting data on how drugs are actually used in the community, and the impact they have on health care resource use and on patient quality of life. Research is also conducted to help determine how both patient and healthcare provider value systems influence the use of drug therapies in clinical practice.

Selected Publications

  1. Levine MAH, Hamet P, Novosel S, Jolain B. A prospective comparison of four study designs used in assessing safety and effectiveness of drug therapy in hypertension management. Amer J Hypertension 1997;10:1-10.
  2. Levine MAH, Lexchin J, Pelizzarri R. Drugs of choice formulary, 3rd Edition. CMA Publishing, Ottawa, 1999.
  3. Heyland DK, Gafni A, Levine MAH. Do potential patients prefer tPA or SK? J Clin Epid 2000;53: 888-894.
  4. Brazier N, Levine MAH. Drug Herb Interaction Among Commonly Used Conventional Medicines: A Compendium for Health Care Professionals. Am J Ther 2003;10(3):163-9.
  5. McCormack JP, Dolovich L, Levine M et al. Providing evidence-based information to patients in general practice and pharmacies: What is the acceptability, usefulness and impact on drug use? Health Expectations 2003;6:281-9.
  6. Levine MAH, Gaebel K. A study of patient responses to a perceived change in salbutamol metered dose inhalers. J Generic Med 2005;2(3):201-208.