Division of Hematology & Thromboembolism

Catherine P.M. Hayward

M.D., Ph.D., F.R.C.P.(C).

Professor, Pathology and Molecular Medicine

Associate Member, Department of Medicine

Head, Coagulation, Hamilton Regional Laboratory Medicine

Member, Faculty of Health Sciences Research Council

Administrative Assistant: Lynne Lacey

Currently accepting Graduate Students.
Currently accepting Post Doctoral Fellows.

Education and Professional Standing

Ph.D. (Gold Medalist) Medical Sciences, McMaster University, 1995
M.D. University of Western Ontario, 1984
B.Sc. Biology, University of Western Ontario, 1980

Research Interests

Blood Clotting and Vascular Repair

The emphasis of our research is on conducting bench to bedside studies of molecules important to blood clotting and vascular repair.

Our studies include investigations of a new protein discovered in our laboratory, named multimerin 1, that functions as an adhesive protein in blood and blood vessels, and as a binding protein for coagulation factor V.

Other studies target the formation and functions of platelets and megakaryocytes, including how they are altered by disease.

In conjunction with the Transfusion Research Program at McMaster University, and clinical services in the hospital, we are developing clinical history assessment tools to evaluate bleeding disorders, and are investigating causes of bleeding problems and platelet disorders.

A condition known as the Quebec Platelet Disorder, was first described by our group. It is the first bleeding disorder associated with increased urokinase-type plasminogen activator, and we are now investigating its genetic cause and how it causes bleeding.

Our research is supported by operating grants from the Heart and Stroke Foundation of Canada and the Canadian Institutes of Health Research, a Heart and Stroke Foundation of Ontario Career Investigator Award, and a Canada Research Chair in Molecular Hemostasis.

Dr. Hayward is President of the North American Special Coagulation Laboratory Association (NASCOLA). Co-Chair of the Scientific Subcommittee on Platelet Physiology of the International Society on Thrombosis and Haemostasis (ISTH) and Chair, Clinician Investigator Program Advisory Committee of the Royal College of Physicians and Surgeons of Canada. She is also elected President of the North American Specialized Coagulation Laboratory Association (2007-present).

Selected Publications

  1. Hayward CPM, Rao AK, Cattaneo M. Congenital platelet disorders: overview of their mechanisms, diagnostic evaluation and treatment. In, State of the Art. XXVII International Congress of the World Federation of Hemophilia. Vancouver, Canada, 21-25 May 2006. Edited by Lee CA, Kessler CM. Haemophilia 2006;12 (Suppl 3):128-136.
  2. Adam F, Zheng S, Joshi N, Kelton DS, Sandhu A, Suehiro Y, Jeimy S, Santos AV, Massé J-M, Kelton JG, Cramer EM, Hayward CPM. Analyses of cellular multimerin 1 receptors: in vitro evidence of binding mediated by alpha IIb beta 3 and alpha v beta 3. Thromb Haemost 2005;94;1004-1011.
  3. Hayward CPM, Fuller N, Zheng S, Adam F, Jeimy S, Horsewood I, Quinn-Allen MA, Kane WH. Human platelets contain forms of factor V in disulfide-linkage with multimerin. Thromb Haemost 2004;92:1349-1357.
  4. Jeimy SB, Woram RA, Fuller N, Quinn-Allen MA, Nicolaes GAF, Dahlbäck B, Kane WH, Hayward CPM. Identification of the multimerin 1 binding region within the C2 domain of human factor V. J Biol Chem 2004;279:51466-51471.
  5. McKay H, Derome F, Haq MA, Whittaker S, Arnold E, Adam F, Heddle N, Rivard GE, Hayward CPM. Bleeding risks associated with inheritance of the Quebec platelet disorder. Blood 2004;104:159-165.
  6. Kahr WH, Zheng S, Sheth P, Pai M, Cowie A, Bouchard M, Podor TJ, Rivard GE, Hayward CPM. Platelets from patients with the Quebec platelet disorder contain and secrete abnormal amounts of urokinase-type plasminogen activator. Blood 2001;98:257-265. Plenary Paper.
  7. Hayward CPM, Hassell J, Denomme G, Rachubinski R, Brown C, Kelton JG. The cDNA sequence of human endothelial cell multimerin: A unique protein with RGDS, coiled-coil, and EGF-like domains, and a carboxyl terminus similar to the globular domain of complement C1q and collagens type VIII and X. J Biol Chem 1995;270:18246-18251.

Team Members

Administrative Assistant: Lynne Lacey

Research Assistants: Dr. Shilun Zheng, Ms. Nola Fuller

Post-Doctoral Fellows: Dr. Subia Tasneem

Graduate Students: Maria Diamandis, Samira Jeimy, Dr. Dragoslava (Kika) Veljkovic, Monika Pawlikowska and
Jenny Yip

Technical Specialist (Coagulation): Karen Moffat