Dr. Paul Kim

Division of Hematology & Thromboembolism

Paul Kim

Ph.D.

Assistant Professor, Department of Medicine

 

 

 

 

 

Education and Professional Standing

Dr. Kim earned his B.Sc.H. from Queen’s University, Kingston, Canada. He also earned his M.Sc. and Ph.D. from Queen’s University under the guidance of Dr. Michael Nesheim, a biophysical chemist. He has completed his Postdoctoral Fellowship at McMaster University under the supervision of Drs. Jeffrey Weitz and Peter Gross. During this time, Dr. Kim has focused his research in the field of thrombosis and hemostasis, specializing in protein-protein interactions and biophysical chemistry. He is currently serving as the co-chairman of the International Society on Thrombosis and Haemostasis (ISTH) Scientific and Standardization Committee (SSC) on Fibrinolysis.

Research Interests

Dr. Kim’s research focuses mainly in the biochemistry of blood coagulation and fibrinolysis, identifying and characterizing various molecular mechanisms of hemostasis. Current proteins of interest include plasminogen, fibrinogen, thrombin-activatable fibrinolysis inhibitor (TAFI), and coagulation factor V(a). To date, he has over 20 peer-reviewed publications and has been funded by various peer-reviewed grants such as CIHR and the Heart and Stroke Foundation of Canada.

Selected Publications

  1. Kim, P.Y., Vu, T.T., Leslie, B.A., Stafford, A.R., Fredenburgh, J.C., Weitz, J.I. (2014) Reduced plasminogen binding and delayed activation render y’-fibrin more resistant to lysis than yA-fibrin. J Biol Chem. 289(40), 27494-503.
  2. Kim, P.Y., Kim, P.Y.G., Taylor, F.B. Jr., Nesheim, M.E. (2012) Thrombin-activatable fibrinolysis inhibitor is activated in vivo in a baboon model of Escherichia coli induced sepsis. J Thromb Thrombolys. 33(4), 412-5.
  3. Kim, P.Y., Tieu, L.D., Stafford, A.R., Fredenburgh, J.C., Weitz, J.I. (2012) A high affinity interaction of plasminogen with fibrin is not essential for efficient activation by tissue plasminogen activator. J Biol Chem. 287(7), 4652-61.