Division of Hematology & Thromboembolism

Dr. Ishac Nazy


Associate Professor, Division of Hematology and Thromboembolism, Department of Medicine

Assistant Professor, Department of Biochemistry and Biomedical Sciences




Research Interests (Summary)

1.       Heparin-induced thrombocytopenia
2.       Immune thrombocytopenia
3.       Thrombosis
4.       Platelet disorders

Education and Professional Standing

1.       PhD, Biochemistry and Biomedical Sciences, McMaster University, 2005
2.       BSc, Biochemistry, McMaster University, 1998
3.       BSc, Physical Sciences, University of Guelph, 1996

Research Interests

My research interests are in the specific interactions between antibodies and their target antigens on platelets, leading to thrombocytopenia and thrombosis.  Heparin induced thrombocytopenia and Immune thrombocytopenic purpura are great models for identifying key factors involved in the pathogenesis of the immune response leading to low platelet counts.  Our research focuses on the cellular and humoral immunity and the downstream effects of antibody production on platelet physiology.   We use our research to identify the pathology from patient samples and create in vitro models that could explain our findings and further our understanding of the issues at hand.

Selected Publications

  1. Kelton, JG, Warkentin, TE, Moore, JC, Arnold, DM, Nazi, I, Arepally, GM, Roach, JM, Fier, I. A prospective study measuring the development of antibodies against platelet factor 4 in healthy males following exposure to heparins. JTH. April (2012)
  2. Toltl, LJ, Nazi, I, Jafari, R, Arnold, DM. Piecing together the humoral and cellular mechanisms of immune thrombocytopenia. Semin Thromb Hemost. Sep 37(6):631-9. (2011).
  3. Nazi, I, Smith, JW, Arnold, DM, Horsewood, P, Moore, JC, Warkentin, TE, and Kelton, JG. The association between platelet activation and FcγRIIa proteolysis. JTH. 9(4): 885-7. (2011).