Division of Nephrology

Jeffrey Dickhout

PhD

Assistant Professor, Division of Nephrology, Department of Medicine

 

 

 

 

 

Academic roles

Dr. Dickhout conducts research in the department of medicine, division of nephrology with laboratories located at St. Joseph’s HealthCare Hamilton in the Hamilton Centre for Kidney Research. He also is an educator in the Faculty of Health Sciences Medical Sciences Graduate Program.

Research Areas

  1. Role of proteinuria in the progression of chronic kidney disease
  2. Mechanisms by which hypertension induces chronic kidney disease
  3. Endoplasmic Reticulum Stress in kidney disease and renal fibrosis

Further information about Education

Dr. Dickhout received his PhD in Medical Sciences from McMaster University. He trained as a Postdoctoral Fellow with Dr. Allen W. Cowley Jr. in the Department of Physiology at the Medical College of Wisconsin in renal physiology. Further Postdoctoral training was obtained in Dr. Richard C. Austin’s laboratory at McMaster University in cardiovascular disease. Dr. Dickhout was the inaugural holder of the Division of Nephrology Junior Researcher award. Dr. Dickhout is currently an Assistant Professor in the Department of Medicine, Division of Nephrology at McMaster University and St. Joseph’s Healthcare Hamilton.

Funding

Dr. Dickhout’s research program is currently supported by the CIHR were he holds funds as Principal Investigator into the Role of endoplasmic reticulum (ER) stress in the development of kidney disease.

Dr. Dickhout also acknowledges support for his research program from St. Joseph’s Healthcare Hamilton and the Hamilton Centre for Kidney Research.

Dr. Dickhout has also held funds as a Co-investigator with Dr. Richard C. Austin to determine small molecules that regulate the expression of the ER stress-inducible gene TDAG51.

Selected Publications

  1. Cowley AW, Jr., Roman RJ, Kaldunski ML, Dumas P, Dickhout JG, Greene AS, Jacob HJ (2001) Brown Norway chromosome 13 confers protection from high salt to consomic Dahl S rat. Hypertension. 37:456-461.
  2. Dickhout JG, Mori T, Cowley AW, Jr (2002) Tubulovascular nitric oxide crosstalk: buffering of angiotensin II-induced medullary vasoconstriction. Circ Res. 91(6):487-493.
  3. Dickhout JG, Hossain GS, Pozza LM, Zhou J, Lhotak S, Austin RC (2005) Peroxynitrite causes endoplasmic reticulum stress and apoptosis in human vascular endothelium: implications in atherogenesis. Arterioscler Thromb Vasc Biol.25(12):2623-2629.
  4. Dickhout JG, and Austin RC (2006) Proteosomal regulation of cardiac hypertrophy: is demolition necessary for building? Circulation 114, 1796-1798.
  5. Dickhout JG, Sood S, and Austin RC (2007) Role of endoplasmic reticulum (ER) calcium disequilibria in the mechanism of homocysteine-induced ER stress. Antioxid. Redox Signal. 9, 1863-1873.
  6. Dickhout JG, Colgan SM, Lhoták S, and Austin RC (2007) Increased endoplasmic reticulum stress in atherosclerotic plaques associated with acute coronary syndrome: a balancing act between plaque stability and rupture. Circulation 116, 1214-1216.
  7. Zhou J, Werstuck GH, Lhoták S, Shi YY, Tedesco V, Trigatti B, Dickhout J, Majors AK, DiBello PM, Jacobsen DW, and Austin RC (2008) Hyperhomocysteinemia induced by methionine supplementation does not independently cause atherosclerosis in C57BL/6J mice. FASEB J. 22:2569-2578.
  8. Dickhout JG, Basseri S, and Austin RC (2008) Macrophage function and its impact on atherosclerotic lesion composition, progression and stability: the good, the bad, and the ugly. Arterioscler. Thromb. Vasc. Biol. 28:1413-1415.
  9. Dickhout, JG., and Krepinsky, JC. (2009) Endoplasmic reticulum stress and renal disease. Antioxid Redox Signal 11, 2341-2352
  10. Caldwell J, Dickhout JG, Al-Hashimi A and Austin RC (2010) Development of a continuous assay for the measurement of tissue factor procoagulant activity on intact cells. Lab. Invest. 90:953-962.
  11. Al-Hashimi, A. A., Caldwell, J., Gonzalez-Gronow, M., Pizzo, S. V., Aboumrad, D., Pozza, L., Al-Bayati, H., Weitz, J. I., Stafford, A., Chan, H., Kapoor, A., Jacobsen, D. W., Dickhout, J.G., and Austin, R. C. (2010) Binding of anti-GRP78 autoantibodies to cell surface GRP78 increases tissue factor procoagulant activity via the release of calcium from endoplasmic reticulum stores. J Biol Chem 285, 28912-28923
  12. Dickhout JG, Lhotak S, Hilditch BA, Basseri S, Colgan SM, Lynn EG, Carlisle RE, Zhou J, Sood SK, Ingram AJ, and Austin RC. (2011) Induction of the unfolded protein response following monocyte to macrophage differentiation augments cell survival in early atherosclerotic lesions. FASEB Journal. 25(2):576-89, 2011
  13. Dickhout JG, Carlisle RE and Austin RC (2011) Inter-relationship between cardiac hypertrophy, heart failure and chronic kidney disease-endoplasmic reticulum stress as a mediator of pathogenesis. Circ Res. 108(5):629-42, 2011
  14. He L., Fan C., Kapoor A., Ingram AJ., Rybak AP., Austin RC., Dickhout J., Cutz JC., Scholey J., and Tang D. (2011) alpha-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells. Nat Commun. 2:307, 2011