Division of Nephrology

Peter Margetts

BSc, MD, PhD, FRCPC

Associate Professor, Division of Nephrology, Department of Medicine

Director, MD/PhD Program, McMaster University

 

 

Education and Professional Standing

  • PhD, Medical Sciences, McMaster University 2003
  • Fellowship, Royal College, Subspecialty Nephrology, McMaster University 1999
  • Fellowship, Royal College, Internal Medicine, 1998
  • MD, McMaster University 1994
  • BSc, Queen's University 1985

Research Interests

I have an active basic science laboratory with research interests in the mechanisms of fibrosis. We specifically look at peritoneal fibrosis and the implication in clinical peritoneal dialysis. We are interested in the epithelial mesenchymal transition and angiogenesis. We use adenovirus to transfer genes to the peritoneal cavity and then study the fibrogenic response. Most recently, we have made some interesting observations about hypoxia and the role in fibrosis, and have developed an interest in T-cells and the interaction with fibrosis.

We also have an active research program in adenovirus based gene transfer to the kidney and progressive renal disease. This is a new area of research for our group, but we already have made some interesting advances. We also have developed a novel adenovirus based gene transfer vector – the gutless, or helper dependent adenovirus.

The lab includes a senior technician, post doc, 3 graduate students, and a project student. As part of the Hamilton Centre for Kidney Research, we have access to advanced basic science technologies and a full level 2 biohazard facility.

Selected Publications

  1. Nathu Z, Dwivedi DJ, Reddan JR, Sheardown H, Margetts PJ, West-Mays JA. Temporal changes in MMP mRNA expression in the lens epithelium during anterior subcapsular cataract formation. Exp Eye Res 2008 (epub).
  2. Margetts PJ. Heparin and the peritoneal membrane. Perit Dial Int (in press).
  3. Cina D, Patel P, Bethune C, Thoma J, Rodrigues JC, Hoff CM, Margetts PJ. Peritoneal morphological and functional changes associated with platelet derived growth factor (Nephrol Dial Transplant epub September 8, 2008)
  4. Zhang J, Oh K-H, Xu H, Margetts PJ. Vascular endothelial growth factor expression in peritoneal mesothelial cells undergoing transdifferentiation. Perit Dial Int 2008; 28:497-504
  5. Gangji AS, Helal BA, Churchill DN, Brimble KS, Margetts PJ. Association between N terminal propeptide B-type natriuretic peptide and markers of hypervolemia. Perit Dial Int 2008; 28:308-311
  6. Ask K, Bonniaud P, Nejman B, Eickelberg O, Margetts PJ, Warburton D, Groffen J, Gauldie J, Kolb M. Progression of TGFβ mediated pulmonary fibrosis depends on the induction of TGFβ receptors I and II. Int J Cell Biol 2007; 40:484-495
  7. Decologne N, Kolb M, Margetts PJ, Menetrier F, Artur Y, Garrido C, Gauldie J, Camu P, Bonniaud P. Transforming growth factor beta 1 induced progressive pleural scarring and subpleural fibrosis J Immunol 2007; 179: 6043-6051)
  8. Brimble KS, Walker M, Margetts PJ, Kundhal KK, Rabbat CG. Meta-Analysis: Peritoneal membrane transport, mortality and technique failure in peritoneal dialysis. J Am Soc Nephrol 2006; 17: 2591-2598.
  9. Dwivedi DJ, Pino G, Banh A, Nathu Z, Howchin D, Margetts P, Sivak JG, West-Mays JA. Matrix Metalloproteinase Inhibitors Suppress TGFβ-Induced Subcapsular Cataract Formation. Am J Path 2006; 168: 69-70.
  10. Bonniaud P, Margetts PJ, Ask K, Flanders K, Gauldie J, Kolb M. TGFβ and Smad3 signaling link inflammation to chronic fibrogenesis. J Immunol 2005; 175:5390-5.
  11. Margetts PJ, Oh KW, Kolb M. Transforming growth factor β: Importance in long term peritoneal membrane changes. Perit Dial Int 2005;25:S15-7.
  12. Bonniaud P, Margetts PJ, Kolb M, Schroeder JA, Kapoun AM, Damm D, Murphy A, Chakravarty S, Dugar S, Higgins L, Protter AA, Gauldie J. Progressive Transforming Growth Factor β1-induced Lung Fibrosis Is Blocked by an Orally Active ALK5 Kinase Inhibitor. Am J Respir Crit Care Med 2005;171(8):889-98.
  13. Gangji A, Rabbat CG, Margetts PJ. Benefit of continuous dialysis in subgroups of acutely ill patients: A retrospective analysis. Clinical Nephrology 2005; 63:267-75.
  14. Margetts PJ, Bonniaud P, Liu L, Hoff CM, Holmes CJ, West-Mays JA, Kelly MM. Transient over expression of transforming growth factor β1 induces epithelial mesenchymal transition in the rodent peritoneum. J Am Soc Nephrol 2005;16(2):425-36.
  15. Motomura Y, Kanbayashi H, Khan WI, Deng Y, Blennerhassett PA, Margetts PJ, Gauldie J, Egashira JK, Collins SM. The gene transfer of soluble VEGF type I receptor (Flt-1) attenuates peritoneal fibrosis formation in mice but not soluble TGF-β type II receptor gene transfer. American Journal of Physiology, Gastrointestinal and Liver Physiology 2005; 288(1): G143-50.
  16. Bonniaud P, Kolb M, Galt T, Robertson J, Robbins C, Stampfli M, Lavery C, Margetts PJ, Roberts AB, Gauldie J. Smad3 null mice develop airspace enlargement and are resistant to TGF-β mediated pulmonary fibrosis. J Immunol 2004 173: 2099-108.
  17. Bonniaud P, Martin G, Margetts PJ, Ask K, Robertson J, Gauldie J, Kolb M. CTGF is crucial to induce a profibrotic environment in "fibrosis resistant" Balb/c mouse lungs. Am J Respir Cell Mol Biol 2004; 31(5):510-6.
  18. Aoki N, Zganiacz A, Margetts P, Xing Z. Differential regulation of DAP12 and its associating molecules during host responses to mycobacterial infection. Infect Immun 2004; 72:2477-83.
  19. Margetts PJ, Bonniaud P. Basic Mechanisms and Clinical Implications of Peritoneal Fibrosis. Perit Dial Int 2003; 23:530-41
  20. Dabrosin C, Margetts PJ, Gauldie J. Estradiol increases extracellular levels of vascular endothelial growth factor in vivo in murine mammary cancer. Int J Cancer 2003; 107: 535-40.
  21. Bonniaud P, Margetts PJ, Kolb M, Haberberger T, Kelly M, Robertson J, Gauldie J. Adenoviral Gene Transfer Of Connective Tissue Growth Factor In The Lung Induces Transient Fibrosis. Am J Respir Crit Care Med 2004; 31: 510-6.