Dr. Joseph Perumpillichira

Division of Neurology

Joseph Perumpillichira


Associate Professor, Division of Neurology, Department of Medicine

Staff Neurologist, Hamilton Health Sciences






Education and Professional Standing

Dr. Perumpillichira is an epileptologist at the Division of Neurology, department of Medicine, McMaster University and Hamilton Health Sciences. He graduated from the Government Medical College, Calicut, and completed a residency in Internal Medicine from the B.J. Medical College, University of Pune as well as a residency in Neurology from the Sri Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Thiruvananthapuram, India. From 1998 to 2003, he worked as assistant professor of Neurology at SCTIMST and was active in the Comprehensive Epilepsy Care Programme, gaining expertise in presurgical evaluation of medically refractory epilepsy, including long-term noninvasive and invasive EEG monitoring, electrocorticography and cortical stimulation and mapping. Subsequently, from 2003 to 2015, he was staff neurologist and clinical neurophysiologist at the Erasmus MC, University Medical Centre at Rotterdam in the Netherlands. In 2010, he defended his PhD thesis on Improvements in neonatal brain monitoring after perinatal asphyxia. In 2013, he did a one-year clinical pediatric epilepsy fellowship at the Mayo Clinic in Rochester, Minnesota. He is currently an associate professor at the Division of Neurology, department of Medicine at the McMaster University and Hamilton Health Sciences.

Research Interests

Dr. Perumpillichira’s main research interests are in clinical epileptology as well as in the development of automated methods of EEG analysis, especially for use in continuous brain monitoring in the intensive care unit. Along with colleagues from Erasmus MC, Rotterdam and Katholieke Universiteit Leuven and Gent University in Belgium, he is involved in the development of a bed-side device for monitoring the brain function in very ill newborn babies.

Selected Scientific Publications

  1. Matic V, Cherian PJ, Koolen N, Naulaers G, Swarte RM, Govaert P, Van Huffel S, De Vos M. Holistic approach for automated background EEG assessment in asphyxiated full-term infants. J Neural Eng 2014;11(6)066007. doi: 10.1088/1741-2560/11/6/066007.
  2. Despotovic I, Cherian PJ,  De Vos M,  Hallez H, Deburchgraeve W, Govaert P, Lequin M, Visser GH, Swarte RM, Vansteenkiste E, Van Huffel S, Philips W. Relationship of EEG sources of neonatal seizures to acute perinatal brain lesions seen on MRI: a pilot study. Human Brain Mapp 2013;34:2402-17.
  3. Cherian PJ, Deburchgraeve W, Swarte RM, De Vos M, Govaert P, Van Huffel S, Visser GH. Validation of a new automated neonatal seizure detection system: a clinician’s perspective. Clin Neurophysiol 2011;122:1490-99.
  4.  Deburchgraeve W, Cherian PJ, De Vos M, Swarte R, Blok JH, Visser GH,  Govaert P,  Van Huffel S. Automated neonatal seizure detection mimicking a human observer reading EEG. Clin Neurophysiol 2008;119:2447-2454.
  5. Cherian PJ, Blok JH, Swarte RM, Govaert P, Visser GH. Heart rate changes are insensitive for detecting postasphyxial seizures in neonates. Neurology 2006;67:2221-23.

For a complete list of scientific publications, please see PubMed