Dr. Param Nair

Division of Respirology

Parameswaran Nair

MD, PhD, FRCP, FRCPC

Canada Research Chair in Airway Inflammometry

Professor, Division of Respirology, Department of Medicine

Adjunct Professor of Medicine, McGill University

Staff Respirologist, Firestone Institute for Respiratory Health

 

 

Educational and Professional Standing

After obtaining his medical degree (MBBS) from the University of Kerala in India in 1988, Dr Nair trained in general and respiratory medicine at the University of Kerala Medical College Hospital in Trivandrum (with an MD for thesis on exercise-induced bronchoconstriction, Diploma in Tuberculosis, and National Board Certification in Respiratory Medicine (DNB), and Royal Sunderland and Royal Sussex County Hospitals in England (MRCP in General Medicine, 1996). He joined the faculty of Health Sciences of McMaster University in 2004 after training in Health Research Methodology, a clinical research fellowship and a PhD under the supervision of Professors Frederick Hargreave and Paul O’Byrne. He was elected a Member of the National Academy of Medical Sciences of India in 1993, Fellow of the College of Chest Physicians in 1999, Fellow of the Royal College of Physicians of London in 2003 and Fellow of the Royal College of Physicians of Canada in 2009 with certification in Internal Medicine and Respirology. In 2005, he was awarded the Ann Woolcock - American Thoracic Society prize for excellence in Asthma Research.

Research Interests

Dr. Nair's research focuses on developing and applying non-invasive measurements of airway inflammation in the treatment of asthma and COPD, particularly in patients with difficult-to-control and prednisone-dependent asthma. His laboratory characterizes the types of bronchitis in airway diseases using measurements in sputum, develops novel biomarkers in sputum, identifies mechanisms of bronchitis and explores novel targeted therapies of bronchitis. He directs the AllerGen National Centre of Excellence Clinical Investigators Consortium for Severe Asthma and is a co-investigator of the Canadian Respiratory Research Network funded by CIHR.

Clinical Interests

Severe asthma, COPD, chronic cough, general respirology, recurrent infective bronchitis, bronchiectasis

Selected Publications

  1. Neighbour H, Boulet LP, Lemiere C, Sehmi R, Leigh R, Sousa AR, Martin J, Dallow N, Gilbert J, Allen A, Hall D, Nair P. Safety and efficacy of an oral CCR3 antagonist in patients with asthma and eosinophilic bronchitis: a randomized, placebo-controlled clinical trial. Clin Exp Allergy 2013 Nov 28. doi: 10.1111/cea.12244. [Epub ahead of print]
  2. Nair P, Ochkur SI, Protheroe C, Radford K, Efthimiadis A, Lee NA, Lee JJ. Eosinophil peroxidase in sputum represents a unique biomarker of airway eosinophilia. Allergy 2013;DOI: 10.1111/all.12206.
  3. Nair P, Gaga M, Zervas E, et al. Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trial. Clin Exp Allergy 2012; 42: 1097-1103.
  4. Hargreave FE, Nair P. Is measuring sputum eosinophils useful in the management of severe asthma? Chest 2011; 139: 1270-3.
  5. Nair P, Pizzichini MM, Kjarsgaard M, Inman MD, Efthimiadis A, Pizzichini E, Hargreave FE, O'Byrne PM. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med 2009 ;360:985-93.
  6. Sindi A, Todd DC, Nair P. Anti inflammatory Effects of Long-Acting {beta}2-Agonists in Patients With Asthma: A Systematic Review and Metaanalysis. Chest 2009; 136: 145-54.
  7. Hargreave FE, Nair P. The definition and diagnosis of asthma. Clin Exp Allergy 2009; 39:1652-8.
  8. D'silva L, Cook RJ, Allen CJ, Hargreave FE, Parameswaran K. Changing pattern of sputum cell counts during successive exacerbations of airway disease. Respir Med 2007; 101 :2217-20.
  9. O'Byrne PM, Parameswaran K. Pharmacological management of mild or moderate persistent asthma. Lancet 2006;368(9537):794-803.
  10. Jayaram L, Pizzichini MM, Cook RJ, Boulet LP, Lemiere C, Pizzichini E, Cartier A, Hussack P, Goldsmith CH, Laviolette M, Parameswaran K, Hargreave FE. Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations. Eur Respir J 2006;27:483-94.
  11. Berlyne GS, Parameswaran K, Kamada D, Efthimiadis A, Hargreave FE. A comparison of exhaled nitric oxide and induced sputum as markers of airway inflammation. J Allergy Clin Immunol 2000;106: 638-44.

Publications cited as Parameswaran K and Nair P

Team Members

    Current

  • Post-doctorate Fellows: Manali Mukherjee, Hui Fang Lim
  • Undergraduate: Jennifer Cheng, Fernando Alleman
  • Technologists: Katherine Radford, Melanie Kjarsgaard, Brenda Helpard, Nicola LaVigne, Chynna Huang
  • Administrative Assistants: Heather Assiginack

Previous Trainees

  • Post-doctoral Fellows: Liesel D'silva (India), John Brannan (Australia), Wendy Wong (Canada), Ahmad Alkhabaz (Kuwait), Marcos Ribeiro (Brazil), Angira Dasgupta (India), Adam Collison (Australia), Svetlana Davydchenko (Belarus)
  • Research Fellows: Nesreen Hassan (Egypt), Aleksander Kania (Poland), Bosco Lui (Canada), George Yuan (Canada), Naomi Spitale (Canada), Sindu Mohan (Canada)
  • Master's Students: Adrian Fanat (Canada), Miki Peer (Canada), Elizabeth Simms (Canada), Amanda Giesler (Canada), Neha Punia (Canada), Afia Aziz-Ur-Rehman (Canada)
  • Undergraduate Students: Laura Cancelliere (Canada), Shannon Riley (Ireland), Susan Armstrong (Canada), Aoife Cox (Canada), Laura Zuccaro (Canada), Mark Monachino (Canada), Cara Pray (Canada), Bhavini Rajkumar (UK)
  • Technologists: Jancy Stephen (Canada), Shauna Denis, Ann Efthimiadis (Canada)

Key collaborators

Drs Neighbour, Larche, Sehmi, Cox, O'Byrne (Respirology); Dr Surette (Molecular Microbiology); Drs Bowdish, Jordana, Richards (Immunology); Dr Mahony (Virology); Dr Trus (Hematology); Dr Brennan (Chemical Engineering); Drs Hamid, Baglole, Martin (McGill); Dr Boulet (Laval), Dr Lemiere (Montreal); Dr Parraga (Western); Dr Foster (Newcastle, Australia); Dr Lee (Mayo, Scottsdale, AZ)