Dr. Andy Wong

Division of Rheumatology

Andy Kin On Wong

PhD

Assistant Clinical Professor (Adjunct), Division of Rheumatology, Department of Medicine

Assistant Scientist, Toronto General Research Institute, University Health Network

Co-Director, Canadian Multi-Centre Osteoporosis Bone and Muscle Quality Studies

Key clinical / research interests: Osteoarthritis, Osteoporosis, Sarcopenia, Aging, Musculoskeletal Imaging, Structural Equation Modeling

 

 

Education and Professional Standing

Dr. Andy Kin On Wong graduated from McMaster University where he completed his PhD in Medical Sciences, focused on comparing bone microarchitecture measurement using various CT and MRI modalities. He completed his post-doctoral fellowship at the University Health Network in Toronto, training in epidemiology while conducting studies related to the effects of vitamin K on muscles, and on risk factors for atypical femur fractures. Aside from his training in Canada, he also completed statistical courses in the United States through Statistical Horizons, with specialization in Structural Equation Modeling, Panel Modeling, and Conditional Process Analysis.

Research Activities


Dr. Wong is currently the co-director of the CaMos BQS and MQS, which is examining over 800 Canadian women across 6 major municipalities (Vancouver, Calgary, Saskatoon, Hamilton, Toronto, Kingston) to measure how bone and muscle structural properties measured by peripheral quantitative CT could complement bone density in predicting fragility fractures over 5 years. He has led similar analyses in the Osteoporotic Fractures in Men Study (N=1130) while interning at UCSF, and is a consultant for the Canadian Health Measures Survey Cycle 5/6 focused on National Bone Health using peripheral CT (N>10,000). Having over 10 years of expertise in musculoskeletal investigations, he now sits on the editorial board for the Journal of Musculoskeletal and Neuronal Interactions.

Research Interests


Dr. Wong’s primary focus is on osteoarthritis of the knee and hip. Using his expertise in medical imaging, he is applying novel techniques such as shear wave ultrasound, T2 mapping, and T1rho imaging to quantify properties of the joint. In addition, his experience quantifying bone microarchitecture affords him the ability to explore properties of the subchondral bone and intramedullary space. His overarching goal is to identify an objective disease-specific feature that correlates well with pain, which could be used for monitoring disease progress and treatment success in the future. He is also interested in identifying sub-groups of osteoarthritis patients, and particularly their cross-talk with osteoporosis, which could merit different strategies for treatment and management.
Aside from his interests in osteoarthritis, Dr. Wong continues to conduct studies related to bone-muscle interactions. By examining the musculoskeletal system as a whole and painting a more complete picture, he believes we may be better capable of targeting reasons why individuals fall and fracture recursively. One key factor underlying the aging musculoskeletal system is frailty. The energy level of the individual interacts intimately with function and strength. As a result, Dr. Wong is interested in how frailty also affects individuals with osteoporosis and osteoarthritis to have worse disease outcomes.

Awards and Honours

2016 CIBC-ARF New Investigator Award
2016 ESCEO-Agnovos Healthcare Young Investigator Award
2014 OC-CaMos Fellowship
2014 TGRI Fellowship Award
2010-2013 Vanier Canada Graduate Scholarship
2013 FHS Open Communication and Collaboration Award
2010 ASBMR Young Investigator Award
2009 CIHR-Master’s Award in the Area of Osteoporosis

Selected Publications

  1. Wong, A.K.O.* (2016). A Comparison of Peripheral Imaging Technologies for Bone and Muscle Quantification: a Mixed Methods Clinical Review. Curr Osteoporosis Rep (DOI: 10.1007/s11914-016-0334-z).
  2. Wong, A.K.O.* (2016). A Comparison of Peripheral Imaging Technologies for Bone and Muscle Quantification: a Technical Review. J Musculoskelet Neuronal Interact. (in press)
  3. Erlandson, M.C.*, Wong, A.K.O., Szabo, E., Vilayphilou, N., Zulliger, M.A., Adachi, J.D., Cheung, A.M. (2016). Muscle and Myotendinous Tissue Properties at the Distal Tibia as assessed by High-Resolution Peripheral Quantitative Computed Tomography. J Clin Dens. (in press)
  4. Li, G., Papaioannou, A., Thabane, L., Levine, M.A.H., Ioannidis, G., Wong, A.K.O., Lau, A., Rockwood, K. & Adachi, J.D. (2016) Modifying the phenotypic frailty model in predicting risk of major osteoporotic fracture in the elderly. JAMDA. (in press)
  5. Wong, A.K.O.*, Beattie, K.A., Min, K.K.H., Merali, Z., Webber, C.E., Gordon, C.L., Papaioannou, A., Cheung, A.M.W. & Adachi, J.D. (2015) A tri-modality comparison of volumetric bone imaging technologies. Part III: SD, SEE, LSC association with fragility fractures. J Clin Dens 18(3):408-418.
  6. Wong, A.K.O.*, Beattie, K.A., Min, K.K.H., Merali, Z., Webber, C.E., Gordon, C.L., Papaioannou, A., Cheung, A.M.W. & Adachi, J.D. (2015) A tri-modality comparison of volumetric bone imaging technologies. Part II: One-year change, long-term precision and least significant change. J Clin Dens 18(2): 260-269.
  7. Wong, A.K.O.*, Beattie, K.A., Min, K.K.H., Webber, C.E., Gordon, C.L., Papaioannou, A., Cheung, A.M.W. & Adachi, J.D. (2015) A tri-modality comparison of volumetric bone imaging technologies. Part I: short-term precision and validity J Clin Dens 18(1):124-135.
  8. Wong, A.K.O.*, Beattie, K.A., Min, K.K.H., Gordon, C.L., Pickard, L., Papaioannou, A. & Adachi, J.D. (2014) Peripheral quantitative computed tomography-derived muscle density and peripheral magnetic resonance imaging-derived muscle adiposity: precision and associations with fragility fractures in women. J Musculoskel Neur Interact 14(4): 401-410.
  9. Wong, A.K.O.*, Cawthon, P.M., Peters, K.W., Cummings, S.R., Gordon, C.L., Sheu, Y., Ensrud, K., Petit, M., Zmuda, J., Orwoll, E., Cauley, J. for the Osteoporotic Fractures in Men (MrOS) Research Group (2014) Bone-Muscle Indices as Risk Factors for Fractures in Men: The Osteoporotic Fractures in Men (MrOS) Study. J Musculoskel Neur Interact 14:3, 246-254.
  10. Wong, A.K.O.*, Beattie, K.A., Emond, P.D., Inglis, D., Duryea, J., Doan, A., Ioannidis, G., Adachi, J.D. & Papaioannou, A. (2009) Quantitative analysis of subchondral sclerosis of the tibia by bone texture parameters in knee radiographs: site-specific relationships with joint space width. Osteoarthritis Cartilage 17: 1453-1460.
  11. Wong, A.K.O.*, Inglis, D., Beattie, K.A., Doan, A., Ioannidis, G., Adachi, J.D. & Papaioannou, A. (2009) Reproducibility of computer-assisted joint alignment measurement in OA knee radiographs. Osteoarthritis Cartilage 17: 579-585.