McMaster University

Medical Sciences
Graduate Program

Scope of Search

Michelle Ghert

Michelle Ghert

MD, FRCSC
Associate Professor

Research Interests

Investigations into the mechanisms of bone destruction and metastasis in primary bone tumours.

My research is focused on primary cell cultures of patient-derived specimens of Giant Cell Tumour of bone and the biologic behaviour of the cells in vitro with respect to bone matrix degradation, angiogenesis and metastasis.


These studies employ a variety of modern cell biology and molecular techniques including:

  1. Primary cell cultures
  2. Multiplex protein detection
  3. Western Blots and zymograms
  4. Chromatin immunoprecipitation and ChIP microarrays
  5. Invasion assays
  6. Matrix degradation assays
  7. Angiogenesis assays
  8. Small inhibitory RNA (siRNA)

Studies are done in collaboration with Dr. Gurmit Singh, who is director of research at the Juravinski Cancer Centre and Professor in the Department of Pathology and Molecular Medicine..

Contact

McMaster University
Juravinski Cancer Centre

telephone: (905) 387-9495 ext. 64902
email: michelle.ghert@jcc.hhsc.ca

Program Area

Cancer & Genetics

Research Focus

Bone tumours, metastasis, bone degradation, primary cell cultures, siRNA, Multiplex protein detection

Selected Publications

  • Surgical management of bone metastases: quality of evidence and systematic review.

    Wood TJ, Racano A, Yeung H, Farrokhyar F, Ghert M, Deheshi BM. Ann Surg Oncol. 2014 Dec;21(13):4081-9. doi: 10.1245/s10434-014-4002-1. Epub 2014 Sep 16.

  • The epigenetic regulation of SOX9 by miR-145 in human chondrosarcoma.

    Mak IW, Singh S, Turcotte R, Ghert M. J Cell Biochem. 2014 Aug 21. doi: 10.1002/jcb.24940.

  • A Translational Study of the Neoplastic Cells of Giant Cell Tumor of Bone Following Neoadjuvant Denosumab.Mak IW, Evaniew N, Popovic S, Tozer R, Ghert M. J Bone Joint Surg Am. 2014 Aug 6;96(15):e127.