Adult Nephrology Residency Training Program

Faculty Publications

Dr. Richard Austin

  1. Duivenvoorden WC, Beatty LK, Lhotak S, Hill B, Mak I, Paulin G, Gallino D, Popovic S, Austin RC and Pinthus JH (2013) Underexpression of tumor suppressor LKB1 in clear cell carcinoma is common and confers growth advantage in vitro and in vivo. Br. J. Cancer108:327-333.
  2. Hossain GS, Lynn EG, Maclean KN, Zhou J, Dickhout JG, Lhoták S, Trigatti B, Capone J, Rho J, Tang D, McCulloch CA, Al-Bondokji I, Malloy MJ, Pullinger CR, Kane JP, Li Y, Shiffman D and Austin RC (2013)Deficiency of TDAG51 protects against atherosclerosis by modulating apoptosis, cholesterol efflux and peroxiredoxin-1 expression. J. Am. Heart Assoc. 2:e000134.
  3. Mani S, Li H, Untereiner A, Wu L, Yang G, Austin RC, Dickhout JG, Lhoták Š, Meng QH and Wang R (2013) Decreased endogenous production of hydrogen sulfide accelerates atherosclerosis. Circulation 127:2523-2534.
  4. Gabriel K, Ingram A, Austin RC, Kapoor A, Tang D, Majeed F, Qureshi T and Al-Nedawi K (2013) Regulation of the tumor suppressor PTEN through exosomes: a diagnostic potential for prostate cancer. PLoS One8:e70047.
  5. Kleinmann N, Duivenvoorden WC, Hopmans SN, Beatty LK, Qiao S, Gallino D, Lhotak S, Daya D, Paschos A, Austin RC and Pinthus JH (2014) Underactivation of the adipose-adiponectin receptor 1 axis in clear cell renal cell carcinoma. Clin. Exp. Metastasis 31:169-183.
  6. Duivenvoorden WC, Paschos A, Hopmans SN, Austin RC and Pinthus JH (2014) Endoplasmic reticulum protein ERp46 in renal cell carcinoma. PLoS One9:e90389.
  7. Yang AE, White EJ, Gyulay G, Egier D, Lhotak S, Szewczyk MM, Chong T, Austin RC, Trigatti BL and Igdoura SA (2014) Inhibition of NEU1 attenuates atherosclerosis in ApoE knockout mice. Arterioscler. Thromb. Vasc. Biol. (in press).
  8. Al-bondokji I, Krepinsky JC, Ingram AI, Dickhout JG, Wang V, and Austin RC (2014) Loss of TDAG51 protects against vascular medial calcification by attenuating smooth muscle cell osteo-chondrogenic differentiation and apoptosis. Circulation (in revision).
  9. He L, Ingram A, Yan J, Wong N, Austin RC, Colgan S, Kedishvili N and Tang D (2014) HSD17B6 reduces type 2 diabetes development via inhibiting SREBP activation. Nature Commun. (in revision).
  10. Fullerton MD, Ford RJ, Stypa SA, Day EA, Lhotak S, Schertzer JD, Austin RC, Kemp BE, and Steinberg GR (2014) Salicylate improves macrophage cholesterol homeostasis via activation of AMPK. J. Lipid Res. (in revision).

Dr. Scott Brimble

  1. Keating, PT, Walsh, M, Ribic CM, Brimble KS. The impact of patient preference on dialysis modality and hemodialysis vascular access. BMC Nephrol 15: 38. doi: 10.1186/1471-2369-15-38, 2014. Senior author
  2. Brimble KS, Mehotra R, Tonelli M, Hawley CM, Castledine C, McDonald SP, Levidiotis V, Gangji AS, Treleaven DJ, Margetts PJ, Walsh M.  Estimated glomerular filtration rate reporting changes recommendations for dialysis initiation. J Am Soc Nephrol 24:1737-42, 2013. First author
  3. Hart RG, Eikelboom JW, Brimble KS, McMurty MS, Ingram AJ. Stroke prevention in atrial fibrillation patients with chronic kidney disease. Can J Cardiol 29 (Suppl 7):S71-78, 2013. 

Dr. Catherine Clase

  1. Barzilay JI, Gao P, Clase CM, Mente A, Mann JF, Sleight P, Yusuf S, Teo KK; on behalf of the OnTARGET/TRANSCEND Investigators. Albuminuria and rapid loss of GFR and risk of new hip and pelvic fractures. Clin J Am Soc Nephrol. 2013;8:233-240
  2. Miller S, Pallan S, Gangji AS, Lukic D, Clase CMMercury-associated nephrotic syndrome: a case report and systematic review of the literature. Am J Kidney Dis. 2013;62:135-8
  3. Levin A, Rigatto C, Brendan B, Madore F, Muirhead N, Holmes D, Clase CM, Tang M, Djurdjev O; CanPREDDICT investigators. Cohort profile: Canadian study of prediction of death, dialysis and interim cardiovascular events (CanPREDDICT) BMC Nephrol. 2013;14:121
  4. Juma S, Thomson B, Lok CE, Clase CM, Blake, PG, Moist L.  Canadian Society of Nephrology Survey shows clinical equipoise for using warfarin in hemodialysis patients with atrial fibrillation.  BMC Nephrol BMC Nephrol. 2013;14:174
  5. Dunkler D, Dehghan M, Teo KK, Heinze G, Gao P, Kohl M, Clase CM, Mann JFE, Yusuf S;  ON TARGET investigators.  Diet and Kidney Disease in High Risk Individuals with Type 2 Diabetes.  JAMA Internal Medicine (formerly Archives of Internal Medicine)  2013:173:1682-92
  6. Juma S, Thomson BK, Lok CE, Clase CM, Blake PG, Moist L.  Warfarin use in hemodialysis patients with atrial fibrillation: decisions based on uncertainty.  BMC Nephrol 2013:14:174-20
  7. Levin A, Rigatto C, Barrett B, Madore F, Muirhead N, Holmes D, Clase CM, Tang M, Djurdjev O; CanPREDDICT Investigators.  Biomarkers of inflammation, fibrosis, cardiac stretch and injury predict death but not renal replacement therapy at 1 year in a Canadian chronic kidney disease cohort. Nephrol Dial Transplant. 2014;29:1037-47
  8. Smyth A, O'Donnell MJ, Yusuf S, Clase CM, Teo KK, Canavan M, Reddan DN, Mann JF.  Sodium Intake and Renal Outcomes: A Systematic Review. Am J Hypertens. 2014 Feb 7. [Epub ahead of print]
  9. Smyth A, Dunkler D, Gao P, Teo KK, Yusuf S, O'Donnell MJ, Mann JF, Clase CM.  The relationship between estimated sodium and potassium excretion and subsequent renal outcomes.  Kidney Int. 2014 Jun 11. doi: 10.1038/ki.2014.214. [Epub ahead of print]

Dr. Jeffrey G. Dickhout

  1. Zahraa Mohammed-Ali, Gaile L. Cruz, Chao Lu, Rachel E. Carlisle, Kaitlyn E. Werner, Kjetil Ask and Jeffrey G. Dickhout. (2014). Development of a model of chronic kidney disease (CKD) in the C57BL/6 mouse with properties of progressive human CKD. BioMed Research International. Last Author Submitted
  2. Ehab Ayaub, Victor Tat, Zahraa Mohammed-Ali, PS Kolb, C Chimbori, S Lhotak, E Lynn, N Hambly, A Naqvi, JC Cruz, MRJ Kolb, RC Austin, MD Inman, Jeffrey G. Dickhout and Kjetil Ask. (2014). UPR-mediated macrophage apoptosis is protective towards pulmonary fibrosis. American Journal of respiratory cell and molecular biology. Co-Author. Submitted. Refereed?: Yes
  3. Tony N. Wang, Xing Chen, Renzhong Li, Bo Gao, Zahraa Mohammed-Ali, Chao Lu, Victoria Yum, Jeffrey G. Dickhout, Joan C. Krepinsky. (2014). SREBP-1 Mediates Angiotensin II-Induced TGFβ1 Upregulation and Glomerular Fibrosis. Journal of the American Society of NEPHROLOGY. : -.
    Co-Author
    Accepted
    Refereed?: Yes
  4. Zahraa Mohammed-Ali, Gaile L. Cruz and Jeffrey G. Dickhout. (2014). Crosstalk between the Unfolded Protein Response and NF-κB-mediated Inflammation in the Progression of Chronic Kidney Disease. Journal of Immunology Research. In Press: -.
    Last Author
    In Press
    Refereed?: Yes
  5. Kaitlyn E. WERNER, Victoria YUM, Chao LU, Muzammil MEMON, Yejin NO, Rachel E. CARLISLE, Kjetil ASK and Jeffrey G. DICKHOUT. (2014). Endoplasmic reticulum stress inhibition reduces essential hypertension through the preservation of resistance blood vessel structure and function. Journal of Hypertension. Under Review: -.
    Last Author
    Submitted
    Refereed?: Yes
    Dr. Jeffrey Dickhout 10
  6. Kaitlyn E. Werner, Victoria Yum, Chao Lu, Rachel E. Carlisle, Kjetil Ask and Jeffrey G. Dickhout. (2014). The endoplasmic reticulum stress inhibitor, 4-Phenylbutyrate, reduces established hypertension in the spontaneously hypertensive rat... Circulation Research.
    Last Author
    Submitted
    Refereed?: Yes
    Funding Sources: Canadian Institutes of Health Research (CIHR) - OSO-115895
  7. Victoria Yum, Chao Lu, Kjetil Ask and Jeffrey G. Dickhout. (2014). ER stress inhibition reduces saltsensitive hypertension, proteinuria, microalbuminuria, and renal interstitial fibrosis in the Dahl saltsensitive rat. Journal of the American Society of Nephrology.
    Last Author
    Submitted
    Refereed?: Yes
    Funding Sources: Canadian Institutes of Health Research (CIHR) - OSO-115895
  8. Carlisle RE , Brimble E , Werner KE , Cruz GL , Ask K , Ingram AJ , Dickhout JG. (2014). 4-Phenylbutyrate Inhibits Tunicamycin-Induced Acute Kidney Injury via CHOP/GADD153 Repression.
    PloS one. 9(1): e84663.
    Last Author
    Published
    Refereed?: Yes
    Funding Sources: Canadian Institutes of Health Research (CIHR) - OSO-115895
  9. Mani S , Li H , Untereiner A , Wu L , Yang G , Austin RC , Dickhout JG , Lhoták S , Meng QH , Wang R. (2013). Decreased endogenous production of hydrogen sulfide accelerates atherosclerosis.. Circulation.
    127(25): 2523-34.
    Co-Author
    Published
    Refereed?: Yes
  10. Wei J, Rahman S, Ayaub EA, Dickhout JG, Ask K. (2013). Protein misfolding and endoplasmic reticulum stress in chronic lung disease.. Chest. 143(4): 1098-105.
    Co-Author
    Published
    Refereed?: Yes
  11. Hossain GS, Lynn EG, Maclean KN, Zhou J, Dickhout JG, Lhoták S, Trigatti B, Capone J, Rho J, Tang D, McCulloch CA, Al-Bondokji I, Malloy MJ, Pullinger CR, Kane JP, Li Y, Shiffman D, Austin RC. (2013). Deficiency of TDAG51 Protects Against Atherosclerosis by Modulating Apoptosis, Cholesterol Efflux, and Peroxiredoxin-1 Expression... Journal of the American Heart Association. 2(3): e000134.
    Co-Author
    Published
    Refereed?: Yes
    Funding Sources: Canadian Institutes of Health Research (CIHR) - OSO-115895

Conference Publications

  1. Zahraa Mohammed-ali, Rachel E. Carlisle, Chao Lu, Kjetil Ask, Jeffrey G. Dickhout. (2014). ER stress inhibition decreased inflammatory response in a CKD mouse model... Canadian Hypertension Congress Abstract
    Last Author
    Accepted
  2. Rachel E. Carlisle, Katelyn A. Colwell, Savas D. Kanaroglou, Chao Lu, Victoria Yum, Jeffrey G. Dickhout. (2014). Endoplasmic reticulum stress inhibition prevents chronic kidney disease independent of blood pressure lowering effects in the Dahl S rat. Canadian Hypertension Congress Abstract
    Last Author
    Accepted
  3. Victoria Yum, Chao Lu, Jeffrey G. Dickhout. (2014). Differences in renal pathological responses found between salt sensitive and salt insensitive hypertension... Canadian Hypertension Congress Abstract
    Last Author
    Accepted
  4. Murphy JH, Kolb PS, Mahmood SH, Ayaub E, Carlisle RE, Mukherjee S, Gravina M, Kolb MRJ, Janssen L, Dickhout JG, Ask K. (2014). The activation of IRE1α is critical for pulmonary fibroblast proliferation and differentiation. The 18th International Colloquium on Lung and Airway Fibrosis Abstract
    Co-Author
    Submitted, Invited?: Yes
  5. Ayaub E, Tat V, Mohammed-ali Z, Kolb PS, Chimbori C, Lhotak S, Lynn E, Hambly N, Naqvi A, Cutz JC, Kolb MRJ, Austin RC, Inman MD, Dickhout JG, Ask K. (2014). UPR and CHOP-mediated macrophage apoptosis protects against bleomycin-induced pulmonary fibrosis... International Colloquium on Lung and Airway Fibrosis Abstract
    Co-Author
    Submitted, Invited?: Yes
  6. Kaitlyn Werner, Victoria Yum, Chao Lu, Rachel E. Carlisle, Yejin No and Jeffrey G. Dickhout. (2014). Endoplasmic stress inhibition preserves endothelial-mediated vasodilation in SHR resistance blood vessels. Canadian Hypertension Congress Abstract
    Last Author
    Accepted, Invited?: No
    Funding Sources: Canadian Institutes of Health Research (CIHR) - MOP-133484
  7. Zahraa Mohammed-Ali, Chao Lu, Edward G. Lynn, Kjetil Ask, Jeffrey G. Dickhout. (2014). Glucoseregulated protein 78 modulates Renal Interstitial Fibrosis in the Angiotensin II/DOCA Salt Model of Chronic Kidney Disease. ASN, Kidney Week 2014 Abstract
    Last Author
    Submitted, Invited?: No
    Funding Sources: Canadian Institutes of Health Research (CIHR) - MOP-133484
    Dr. Jeffrey Dickhout 13
  8. E. Ayaub, A. Bhargava, J. Murphy, P. Kolb, S. Lhotak, C. Richards, M.R.J. Kolb, R. Austin, J.G. Dickhout, K. Ask. (2014). FKBP13 deficiency leads to increased pulmonary ER stress, inflammation and fibrosis after bleomycin administration. American Thoracic Society Abstract
    Co-Author
    Published, Invited?: No
  9. J. Murphy, A. Bhargava, E. Ayaub, J. Khaira, A.G. Alipio, P. Kolb, M.R.J. Kolb, J.G. Dickhout, M.W. Surber, K. Ask. (2014). Short Duration Pirfenidone Exposure Inhibits LPS Induced IL1β Production and Myofibroblast Differentiation Activity. American thoracic society Abstract
    Co-Author
    Published, Invited?: No
  10. Jinxian Xu, Jianchun Chen, Kaitlyn E. Werner, Jeffrey G. Dickhout, and Jian-Kang Chen. (2014). HoxB7.Cre-mediated mVps34 Deletion inhibits nephrogenesis and causes nephron hypertrophy. ASN, Kidney Week 2014 Abstract
    Co-Author
    Submitted, Invited?: No
  11. E. Ayaub, V. Tat, A. Bhargava, E. Lynn, C. Shimbori, M.R.J. Kolb, R. Austin, J.G. Dickhout, K. Ask. (2014). Grp78 heterozygosity abrogates bleomycin-induced lung fibrosis by modulating ER-resident protein folding capacity. American Thoracic Society Abstract
    Co-Author
    Published, Invited?: No
  12. Rachel E Carlisle, Kjetil Ask, Jeffrey G Dickhout. (2014). The endoplasmic reticulum stress inhibitor, 4-phenylbutyrate, attenuates chronic kidney disease induced by a model of cardiorenal syndrome. Experimental Biology, 2014, San Diego Abstract
    Last Author
    Published, Invited?: No
    Funding Sources: Canadian Institutes of Health Research (CIHR) - OSO-115895
  13. Kaitlyn Werner, Victoria Yum, Chao Lu and Jeffrey G. Dickhout. (2013). The Endoplasmic Reticulum Stress Inhibitor, 4-Phenylbutyrate, Reduces Hypertension in the Spontaneously Hypertensive Rat Model of Essential Hypertension... American Society of Nephrology Paper
    Last Author
    Published, Invited?: No
    Funding Sources: Canadian Institutes of Health Research (CIHR) - OSO-115895
  14. Victoria Yum, Chao Lu, Jeffrey G. Dickhout. (2013). Endoplasmic reticulum stress inhibitor, 4-PBA, preserves renal myogenic constriction and inhibits hypertension induced proteinuria and renal pathology in the Dahl salt sensitive hypertensive rat... 2013 Canadian Hypertension Congress Abstract
    Last Author
    Published, Invited?: No
    Funding Sources: Canadian Institutes of Health Research (CIHR) - OSO-115895
  15. Jeffrey G. Dickhout. (2013). The role of endoplasmic reticulum stress in the chronic inflammatory response in kidney disease... 2nd International Conference on Nephrology & Therapeutics Abstract
    First Listed Author
    Published, Invited?: Yes
    Dr. Jeffrey Dickhout 14
  16. E. Ayaub, J. Wei, M.H. Lynch, A. Bhargava1, V. Yum, J.A. Smith, M.D. Inman, M.R.J. Kolb, J.G. Dickhout, K. Ask. (2013). 4-Phenylbutyrate prevents UPR activation and myofibroblast differentiation in experimental bleomycin induced lung fibrosis. American Thoracic Society, 2013 Abstract
    Co-Author
    Published, Invited?: No
  17. Zahraa Mohammed-Ali, Chao Lu, Gaile L. Cruz, Edward G. Lynn, Richard C. Austin, Kjetil Ask and Jeffrey G. Dickhout. (2013). The ER stress chaperone and Unfolded Protein Response (UPR) regulator GRP78 modulates cardiac hypertrophy... the International Cardiology Symposium - A Global Agenda (ICS-13). Paper
    Last Author
    Published, Invited?: Yes
    Funding Sources: Canadian Institutes of Health Research (CIHR) - OSO-115895
  18. Faryal Hussain, Elise Brimble, Jeffrey G. Dickhout... (2013). The HDAC inhibitor, vorinostat, prevents TGF-Beta1 induced EMT and apoptosis in human renal proximal tubular cells... Experimental Biology, 2013 Poster
    Last Author
    Published, Invited?: No
    Funding Sources: Canadian Institutes of Health Research (CIHR) - OSO-115895
  19. Zahraa Mohammed-Ali1, Gaile L Cruz, Baqer Jafar, Richard C Austin, Jeffrey G. Dickhout... (2013). ER stress and a chronic inflammatory response are induced in an Angiotensin II/DOCA salt model of chronic kidney disease... Experimental Biology, 2013
    Poster
    Last Author
    Published, Invited?: No
  20. Rachel E Carlisle, Zahraa Mohammed-Ali, Jeffrey G Dickhout. (2013). 4-phenylbutyrate protects against angiotensin II/DOCA salt-induced hypertension in a C57BL/6 mouse model of chronic kidney disease. Experimental Biology, 2013 Poster
    Last Author
    Published, Invited?: No

Dr. Azim Gangji

  1. Myocardial injury after noncardiac surgery: a large, international, prospective cohort study establishing diagnostic criteria, characteristics, predictors, and 30-day outcomes. Vision Investigators.  Anesthesiology. 2014 Mar;120(3):564-78
  2. Estimated GFR reporting influences recommendations for dialysis initiation.  Brimble KS, Mehrotra R, Tonelli M, Hawley CM, Castledine C, McDonald SP, Levidiotis V, Gangji AS, Treleaven DJ, Margetts PJ, Walsh M.  J Am Soc Nephrol. 2013 Nov;24(11):1737-42
  3. Vascular access for intensive maintenance hemodialysis: a systematic review for a Canadian Society of Nephrology clinical practice guideline. Mustafa RA, Zimmerman D, Rioux JP, Suri RS, Gangji A, Steele A, MacRae J, Pauly RP, Perkins DN, Chan CT, Copland M, Komenda P, McFarlane PA, Lindsay R, Pierratos A, Nesrallah GE.  Am J Kidney Dis. 2013 Jul;62(1):112-31
  4. Mercury-associated nephrotic syndrome: a case report and systematic review of the literature. Miller S, Pallan S, Gangji AS, Lukic D, Clase CM.  Am J Kidney Dis. 2013 Jul;62(1):135-8. doi: 10.1053/j.ajkd.2013.02.372. Epub 2013 Apr 18.
  5. Dialysate calcium concentration and mineral metabolism in long and long-frequent hemodialysis: a systematic review and meta-analysis for a Canadian Society of Nephrology clinical practice guideline. Zimmerman DL, Nesrallah GE, Chan CT, Copland M, Komenda P, McFarlane PA, Gangji A, Lindsay R, MacRae J, Pauly RP, Perkins DN, Pierratos A, Rioux JP, Steele A, Suri RS, Mustafa RA.  Am J Kidney Dis. 2013 Jul;62(1):97-111
  6. Canadian Society of Nephrology guidelines for the management of patients with ESRD treated with intensive hemodialysis.  Nesrallah GE, Mustafa RA, MacRae J, Pauly RP, Perkins DN, Gangji A, Rioux JP, Steele A, Suri RS, Chan CT, Copland M, Komenda P, McFarlane PA, Pierratos A, Lindsay R, Zimmerman DL. Am J Kidney Dis. 2013 Jul;62(1):187-98

Dr. Alistair Ingram

  1. Stroke prevention in atrial fibrillation patients with chronic kidney disease. Hart RG, Eikelboom JW, Brimble KS, McMurtry MS, Ingram AJ.Can J Cardiol. 2013 Jul; 29 (7 Suppl):S71-8. Review.
  2. Caveolin-1 deficiency protects against mesangial matrix expansion in a mouse model of type 1 diabetic nephropathy. Guan TH, Chen G, Gao B, Janssen MR, Uttarwar L, Ingram AJ, Krepinsky JC. Diabetologia. 2013 Sep; 56(9):2068-77.
  3. TGFβ receptor I transactivation mediates stretch-induced Pak1 activation and CTGF upregulation in mesangial cells. Hen G, Chen X, Sukumar A, Gao B, Curley J, Schnaper HW, Ingram AJ, Krepinsky JC.J Cell Sci. 2013 Aug 15;126(Pt 16):3697-712.
  4. Colchicine attenuates renal injury in a model of hypertensive chronic kidney disease. Guan T, Gao B, Chen G, Chen X, Janssen M, Uttarwar L, Ingram AJ, Krepinsky JC. Am J Physiol Renal Physiol. 2013 Nov 15; 305(10):F1466-76.
  5. Regulation of the tumor suppressor PTEN through exosomes: a diagnostic potential for prostate cancer. Gabriel K, Ingram AJ, Austin R, Kapoor A, Tang D, Majeed F, Qureshi T, Al-Nedawi K. PLoS One. 2013 Jul 25; 8(7):e70047.
  6. 4-Phenylbutyrate inhibits tunicamycin-induced acute kidney injury via CHOP/GADD153 repression. Carlisle RE, Brimble E, Werner KE, Cruz GL, Ask K, Ingram AJ, Dickhout JG. PLoS One. 2014 Jan 8; 9(1):e84663.

Dr. Joan Krepinsky

  1. Guan TH, Chen G, Gao B, Janssen MR, Uttarwar L, Ingram AJ, Krepinsky JC. Caveolin-1deficiency protects against mesangial matrix expansion in a mouse model of type 1 diabetic nephropathy. Diabetologia 56:2068-2077, 2013.
  2. Chen G, Chen X, Sukumar A, Gao B, Ingram AJ, Krepinsky JC. Pak1 mediates stretch induced CTGF upregulation in kidney mesangial cells. J Cell Sci126(16):3697-3712, 2013.
  3. Guan T, Gao B, Chen G, Chen X, Janssen M, Uttarwar L, Ingram AJ, Krepinsky JC. Colchicine attenuates renal injury in a model of hypertensive chronic kidney disease. Am J Physiol Renal Physiol 305:F1466-F1476, 2013.

Dr. Peter Margetts

  1. Walkin L, Herrick SE, Summers A, Brenchley PEC, Hoff CM, Korstanje R, Margetts PJ. The role of mouse strain differences in the susceptibility to fibrosis – A systematic review. Fibrogenesis Tissue Repair. 2013; 6: 18.
  2. Oh KH, Kim YL, Lo WK, Margetts PJ. Peritoneal dialysis-moving from current status to the future. Int J Nephrol. 2013;2013:530713. Epub 2013 Oct 24.
  3. Brimble KS, Mehrotra R, Tonelli M, Hawley CM, Castledine C,  Szczech LA, McDonald SP, Levidiotis V, Gangji AS, Treleaven DJ, Margetts PJ, and Walsh M. Estimated GFR reporting influences recommendations for dialysis initiation. J Am Soc Neph. 2013; 24: 1737-1742
  4. Ghayur A, Margetts PJ. Transforming Growth Factor Beta and the Glomerular Filtration Barrier. Kidney Research and Clinical Practice. 2013; 32: 3-10.

Dr. Damu Tang

  1. Kathleen Gabriel, Alistair Ingram, Richard Austin, Anil Kapoor, Damu Tang, Talha Qureshiand Khalid Al-Nedawi. Regulation of the tumor suppressor PTEN through exosomes: A diagnostic potential for prostate cancer. PLoS ONE 8, e70047, July, 2013.
  2. Xiaozeng Lin, Lijian Tao, and Damu Tang. Gene Therapy, A Targeted Treatment for Diabetic Nephropathy. Current Medicinal Chemistry 20, 3774-84, Nov. 2013.
  3. Nazihah Bakhtyar, Nicholas Wong, Anil Kapoor, Jean-Claude Cutz, Brianne Hill, Michelle Ghert, and Damu Tang. Clear cell renal cell carcinoma induces fibroblasts-mediated production of stromal periostin. European Journal of Cancer49, 3537-3546, Nov. 2013.
  4. Adrian P. Rybak and Damu Tang. SOX2 Plays a Critical Role in EGFR-mediated Self-Renewal of Human Prostate Cancer Stem-like Cells. Cellular Signalling 25, 2734-2742, Dec. 2013.
  5. Li HT, Song XY, Yang C, Li Q, Tang D, Tian WR, and Liu Y. Effect of hematoporphyrin monomethyl ether-mediated PDT on the mitochondria of canine breast cancer cells. Photodiagnosis and Photodynamic Therapy 10, 414-21, Dec. 2013.
  6. Xiaozeng Lin, Judy Yan, and Damu Tang. ERK kinases modulate the activation of PI3 kinase related kinases (PIKKs) in DNA damage response. Histology and Histopathology28, 1547-1554, Dec. 2013.
  7. Jason De Melo, Lizhi He,and Damu Tang. The Protein-Protein interaction-mediated inactivation of PTEN. Current Medicinal Chemistry 13, 22-33, January, 2014.
  8. Nicholas Wong,Diane Ojo, Judy Yan, and Damu Tang. PKM2 Contributes to Cancer Metabolism. Cancer Letters,2014 Feb 4. pii: S0304-3835(14)00088-3. doi: 10.1016/j.canlet.2014.01.031.
  9. Judy Yan, Jason De Melo,Tariq Aziz, Jean-Claude Cutz, and Damu Tang. Aldehyde dehydrogenase 3A1 associates with prostate tumorigenesis. British Journal of Cancer 110, 2593-603, May 13, 2014.

Dr. Darin Treleaven

  1. Klarenbach S, Gill JS, Knoll G, Caulfield T, Boudville N, Prasad GV, Karpinski M, Storsley L, Treleaven D, Arnold J, Cuerden M, Jacobs P, Garg AX; Donor Nephrectomy Outcomes Research (DONOR) Network. Economic consequences incurred by living kidney donors: a Canadian multi-center prospective study. Am J Transplant. 2014 Apr;14(4):916-22.
  2. Thomas SM, Lam NN, Huang A, Nash DM, Prasad GV, Knoll GA, Koval JJ, Lentine KL, Kim SJ, Alam A, Lok CE, Treleaven DJ, Garg AX; Donor Nephrectomy Outcomes Research (DONOR) Network. Risk of serious gastrointestinal bleeding in living kidney donors. Clin Transplant. 2014 May;28(5):530-9.
  3. Young A, Kim SJ, Garg AX, Huang A, Knoll G, Prasad GV, Treleaven D, Lok CE; for the Donor Nephrectomy Outcomes Research (DONOR) Network. Living kidney donor estimated glomerular filtration rate and recipient graft survival. Nephrol Dial Transplant. 2013 Oct 21.

Dr. Michael Walsh

  1. Walsh M, Farschou M, Berden A, Flossmann O, Westman K, Hoglund P, Szpirt W, Tesar V, Jayne DJ. Long-term follow-up of cyclophosphamide compared to azathioprine for initial maintenance therapy of ANCA associated vasculitis. Clinical Journal of the American Society of Nephrology. 2014. (doi: 10.2215/​CJN.00100114).
  2. Garg AX, Devereaux PJ, Coca S, Cook R, Favoloro R, Jain A, Lawrence M, Noiseux N, Novick R, Ou Y, Parikh C, Parvathanen S, Vik K, Walsh M, Whitlock R, Xiang B, Yusuf S, Lamy A. Kidney function after off-pump or on-pump coronary-artery bypass grafting. J American Med Assoc. 2014. 311 (21), 2191-2198.
  3. Shah M, Jain AK, Brunelli S, Coca SG, Devereaux PJ, James MT, Luo J, Molnar AO, Mrkobrada M, Pannu N, Parikh CR, Paterson M, Shariff S, Wald R, Walsh M, Whitlock R, Wijeysundera DN, Garg AX. Association between angiotensin converting enzyme inhibitor or angiotensin receptor blocker use prior to major elective surgery and the risk of acute dialysis. BMC Nephrology. 2014. 15 (1): 53.
  4. Manns B, Barrett B, Evans M, Garg A, Hemmelgarn B, Kappel J, Klarenbach S, Madore F, Parfrey P, Samuel S, Soroka S, Suri R, Tonelli M, Wald R, Walsh M, Zappitelli M. Establishing a national knowledge translation and generation network in kidney disease: the CAnadian KidNey KNowledge TraNslation and GEneration NeTwork. Canadian Journal of Kidney Health and Diseases. 2014, 1:2.
  5. Garg AX, Vincent J, Cuerden M, Parikh C, Devereaux PJ, Teoh K, Yusuf S, Hildebrand A, Lamy A, Zuo Y, Sessler DI, Shah P, Abbasi S, Quantz M, Yared JP, Noiseux N, Tagarakis G, Rochon A, Pogue J, Walsh M, Chan MTV, Lamontagne F, Salehiomran A, Whitlock R. Steroids in cardiac surgery (SIRS) trial: acute kidney injury substudy protocol of an international randomized controlled trial. BMJ Open. 2014; 4; 3; e004842.
  6. Garg AX, Kurz A, Sessler DI, Cuerden M, Robinson A, Mrkobrada M, Parikh C, Mizera R, Jones PM, Tiboni M, Rodriguez RG, Popova E, Gomez MFR, Meyhoff CS, Vanhelder T, Chan MTV, Torres D, Parlow J, Clanchet M, Amir M, Bidgoli S, Pasin L, Martinsen K, Malaga G, Myles P, Acedillo R, Roshanov P, Walsh M, Dresser G, Kumar P, Fleischmann E, Villar JC, Painter T, Biccard B, Bergese S, Srinathan S, Cata JP, Chan V, Mehra B, Leslie K, Whitlock R, Devereaux PJ. Aspirin and clonidine in cardiac surgery: acute kidney injury substudy protocol of the perioperative ischemia evaluation randomized controlled trial. BMJ Open. 2014; 4; e004886.
  7. Keating P, Walsh M, Ribic C, Brimble S. The impact of patient preference on dialysis modality and hemodialysis vascular access. BMC Nephrology. 2014. 15 (1), 38.
  8. Cybulsky A, Walsh M, Knoll G, Hladunewich M, Bargman J, Reich H, Humar A, Samuel S, Bitzan M, Zappitelli M, Dart A, Mammen C, Pinsk M, Muirhead N. Canadian Society of Nephrology commentary on the 2012 KDIGO clinical practice guidelines for glomerulonephritis: management of glomerulonephritis in adults. Am J Kidney Dis. 2014. 63(3): 363-377.
  9. Samuel S, Bitzan M, Zappitelli M, Dart A, Mammen C, Pinsk M, Cybulsky A, Walsh M, Knoll G, Hladunewich M, Bargman J, Reich H, Humar A, Muirhead N. Canadian Society of Nephrology commentary on the 2012 KDIGO clinical practice guidelines for glomerulonephritis: management of nephrotic syndrome in children. Am J Kidney Dis. 2014. 63(3): 354-362.
  10. Lamontagne F, McIntyre L, Dodek PE, Heels-Ansdell D, Pemberton J, Meade M, Skrobik Y, Seppalt I, Vlahakis N, Muscedere J, Reece G, Ostermann M, Padayachee S, Alhashemi J, Walsh M, Lewis B, Schiff D, Moody A, Zytaruk N, LeBlanc M, Cook DJ for the PROTECT Investigators, the Canadian Critical Care Trials Group and the Australian and New Zealand Intensive Care Society Trials Group.  Non-Leg Venous Thrombosis in Critically Ill Adults: A Nested Prospective Cohort Study. JAMA Intern Med 2014. 174(5):689-696.
  11. Walsh M, Srinathan S, McAuley DF, Mrkobrada M, Levine O, Ribic C, Molnar AO, Dattani ND, Burke A, Guyatt G, Thabane L, Walter SD, Pogue J, and Devereaux PJ. The statistical significance of randomized controlled trial results: a case for a Fragility Index. J Clin Epidemiology. 2014. 67 (6), 622-628.
  12. Botto F, Alonso-Coello P, Chan MTV, Villar JC, Xavier D, Srinathan S, Guyatt G, Cruz P, Graham M, Wang CY, Berwanger O, Pearse RM, Biccard B, Abraham V, Malaga G, Hillis G, Rodseth R, Cook D, Polanczyk C, Szczeklik W, Sessler D, Sheth T, Ackland G, Leuwer M Garg AX, LeManach Y, Pettit S, Heels-Ansdell D, Lurati-Buse G, Walsh M, Sapsford R, Schunemann H, Kurtz A, Thomas S, Mrkobrada M, Thabane L, Gerstein H, Paniagua P, Nagele P, Raina P, Yusuf S, Devereaux PJ. Myocardial Injury after Noncardiac Surgery:  A large international prospective cohort study establishing diagnostic criteria, characteristics, predictors, and 30-day outcomes. Anesthesiology. 2014. 120 (3), 564-578.
  13. Klarenbach S, Tonelli M, Pauly R, Walsh M, Culleton B, So H, Hemmelgarn B, Manns B. Economic evaluation of frequent home nocturnal hemodialysis based on a randomized controlled trial. J Am Soc Neph. 2014. Doi 10.1681/ASN.2013040360.
  14. Walsh M, Devereaux PJ, Garg AX, Kurz A, Turan A, Rodseth R, Cywinski J, Thabane L, Sessler DI. The relationship between intraoperative mean arterial pressure and clinical outcomes after noncardiac surgery: towards an empirical definition of hypotension. Anesthesiology. 2013. 119 (3); 507-515.
  15. Brimble KS, Mehotra R, Tonelli S, Hawley C, Castledine C, Leviodotis V, MacDonald S, Gangji A, Treleaven D, Margetts P, Walsh M. The effect of reporting eGFR on likelihood of initiating dialysis. J Am Soc Neph. 2013. 24:1737-1742.
  16. Walsh M, Garg AX, Devereaux PJ, Aragalous M, Honar H, Sessler D. Decrements in hemoglobin concentration are associated with acute kidney injury after noncardiac surgery. Anesthesia and Analgesia. 2013. 117(4): 924-931.