Juravinski Cancer Centre
699 Concession Street
Hamilton Ontario, L8V 5C2
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Dr. Hotte is the Head of the Phase I Research Program and Chair of the Head and Neck Disease Site Group. Provincially, he is the co-chair of the Genitourinary disease site group of the Program for Evidence Based Care (PEBC) of Cancer Care Ontario. His translational research areas of interest are the molecular biology of human cancers with regards to drug development and the discovery of biomarkers of toxicity and efficacy for novel targeted agents.
Dr. Hotte's clinical research interests include the use of novel compounds, especially those affecting pathways involved in cell signaling and invasion and metastasis, in the treatment of human malignancy (with special interest in inducers of apoptosis and oncolytic viral therapy), randomized controlled trials of various therapeutic modalities for the treatment of genito-urinary and head and neck cancers, and the generation of practice guidelines as part of the Cancer Care Ontario PEBC. He is also interested in the study of novel trial methodologies and various methodological issues of clinical trials in oncology.