Coffee Breaks, Lunch and Poster Presentations will be in the lobby of Earth Sciences Centre

Graduate Student and Post Doc Pub at Faculty of Pharmacy ((19 Russell St.), May 21st, 2004 7:15PM) Rm 102 organized by Pharmaceutical Sciences Graduate Student Association. Come and Enjoy pizza and drinks. Professors and postdocs are welcome to attend if they would like.

Banquet on Saturday (May 22nd, 2004 at 7:30PM): Alumni Hall at Victoria College

The poster boards are 6' x 3'.
The program has been revised.
 
 

4th Annual Meeting of the Oxidative Stress Consortium on Health and Disease 2004
Program
Oral Presentations: Earth Sciences Centre: Room 1050 (Reichmann Family Lecture Hall)
FRIDAY, May 21

12:00   Registration

12:30-12:40  General Welcome
Dean Hindmarsh and Peter O’Brien, Faculty of Pharmacy, University of Toronto

Session I:  Pathogenesis of Oxidative Stress

Chair: Peter Pennefather

12:40-1:10 Peter J. O’Brien and trainee-Arno Siraki (Faculty of Pharmacy, U of T) “Early toxicity screening of candidate drugs for oxidative stress”

1:10-1:40 Jack Uetrecht (Faculty of Pharmacy, U of T) “Mechanisms of idiosyncratic drug reactions.”

1:40-2:10 Jack Bend (UWO) “Bilirubin and arsenite mediated changes in drug metabolizing enzymes; role of oxidant stress.”

2:10-2:40  Bernhard Juurlink (Saskatchewan Stroke Research Centre, U of Sask)   “Dietary phase 2 protein inducers inhibit oxidative stress-driven aging-related pathologies”

2:40-2:55 Coffee/Tea break

2:55-3:25 Peter G. Wells (Faculty of Pharmacy, U of T) “Oxidative stress in birth defects and neurodegeneration”

3:25-3:55 Gediminas Cepinskas (Department of Physiology and Pharmacology, UWO) “Oxidative Stress in the brain during sepsis”

3:55-4:25  Jacques Huot (Department of Medicine, Laval University) “Oxidative stress signalling to cytoskeleton dynamics”

4:25-4:55 Rick Austin (Department of Pathology, McMaster University) “The pathogenesis of endoplasmic reticulum stress”

4:55-5:25 Bill Milgram (Department of Pharmacology, U of T) “Retardation of neurobiological aging in beagle dogs by an antioxidant fortified diet: a two year longitudinal study”

5:25-6:00 Coffee/Tea Break
 

FRIDAY, May 21

6:00-7:00PM Public lecture

John Wilson (Department of Physiology and Pharmacology, UWO) “Vitamin C antioxidant therapy really benefit our health?”

7:15PM Graduate Student and Post Doc Pub organized by Pharmaceutical Sciences Graduate Student Association (Rm 102-Faculty of Pharmacy).

SATURDAY, May 22

Session II: Oxidative Stress, Cardiovascular disease and iron homeostasis

Chair: Bernhard Juurlink

8:00-8:30 Pawan Singal (U of Manitoba) “Oxidative Stress, Cytokines and Heart Failure”

8:30-9:00 Naranjan S. Dhalla (Institute of Cardiovascular Sciences, U of Manitoba) “Role of oxidative stress in remodeling of subcellular organelles in the heart.”

9:00-9:30 Ashok Grover (Department of Medicine, McMaster University) “ATP-induced ascorbate release from pig coronary artery endothelial cells”

9:30-10:00 Peter Yu (U of Sask) “Involvement of semicarbazide-sensitive amine oxidase (SSAO)-mediated oxidative deamination in vascular damages associated with diabetic complications and other disorders”

10:00-10:15 Coffee/Tea Break

10:15 -10:45 Peter Backx (Department of Physiology, U of T) “Oxidative Stress, iron and cardiovascular function”

10:45-11:15 Prem Ponka (McGill University) “Induction of heme oxygenase-1 by ‘oxidative
stress’ does not apparently increase cytosolic iron levels”

11:15 -11:45  Kostas Pantopoulos (McGill University) “Iron regulatory proteins”

11:45-12:15 Doug Templeton (Department of Laboratory Medicine and Pathobiology, U of T) “Cellular Non-transferrin bound iron accumulation”

12:15-1:30 Lunch and Poster Session I

SATURDAY, May 22

Poster Session I

1. Beth Acton (U of T) ““Markers of mitochondrial function reflect quality or murine oocytes”

2.         Katie Chan (U of T) “Hepatocytes as the gold standard for predicting in vivo
hepatotoxicity of xenobiotics using ‘accelerated cytotoxicity mechanism screening
techniques’”

3. Cyrstal Lee (U of T) “ Flurothalidomide: a model compound for determining the
steroselective role of thalidomide teratogenesis”

4. Cleo Leuong (U of T) “The hepatotoxicity and neurotoxicity of trihaloethanol anesthetics
via the action of cytochrome P450 (CYP450) encourage lipid peroxidation in liver and brain”

5. Jordan Oliver (UWO) “Impaired Hepatic Regeneration in Metallothionein Null Mice After Partial Hepatectomy”

6. Julia Perstin (U of T) “Embryonic catalase activity during organogenesis with endogenous and phenytoin-enhanced oxidative stress”

7. Marija Popovic (U of T) “Covalent Modification of Liver and Bone Marrow Tissues by 2-Phenylpropenal in vitro and in vivo”

8. Annmarie Ramkissoon (U of T) “Neuroprotection against endogenous oxidative stress in aging Prostaglandin H synthase-1 (PHS-1) knockout mice”

9. Nandita Shangari (U of T) “Increase in glyoxal toxicity due to thiamin deficiency: Implications for Diabetes Mellitus”

Session III: Therapies, Techniques and New Molecular Targets

Chair: Diana Averill-Bates

1:30-2:00 Rob Bristow (Department of Medical Biophysics, U of T) “Visualization of nuclear DNA repair complexes in vivo as a means to assess DNA damage and its repair”

2:00-2:30 Richard Hill (Medical Biophysics, U of T) “Oxidative stress in lung tissue following irradiation”
 

SATURDAY, May 22

Session III: Therapies, Techniques and New Molecular Targets

Chair: Diana Averill-Bates

2:30-3:00 Bob Bruce (Department of Nutrition, U of T) “How can we decrease colon cancer risk? Rat partial thiamin deficiency studies”

3:00-3:30 Jim Wright (Department of Chemistry, Carlton Univ) “Designer antioxidants”

3:30-4:00 John Connelly (APOPHARMA) “Anti-oxidant activities of some hydroxypyridinones: The importance of physiologically relevant In Vitro studies”

4:00-4:15 Coffee/Tea Break

4:15-4:45  Brian Hasinoff (U of Manitoba) “Prevention of iron-based doxorubicin cardiotoxicity by dexrazoxane”

4:45-5:15 David Josephy (University of Guelph) “Environmental mutagenic heterocyclic aromatic amines possible activation by peroxidases in breast milk”

5:15-5:45 Raymond Poon (Health Canada) and trainee-Tom Chan (Department of Pharmaceutical Sciences, U of T) “Drug and pollutant induced  ascorbic acid excretion in experimental animals -  Current status and possible mechanisms of action”

5:45-7:00 Poster Session II

Poster Session II

10. Carine Filbeen (McGill University) “A phosphomimetic mutation at Ser-711 inactivates iron regulatory protein 1”

11. Adriana Krizova (UWO) “Effect of HIV-1 Tat Protein Differential Expression on Cellular Sensitivity of Sulphamethoxazole Hydroxlamine (SMX-HA)”

12. Margaret Loniewska (U of T) “Regional brain activity of G6PD activity in G6PD-normal and mutant G6PD-deficient mice”
 

SATURDAY, May 22

Poster Session II

13. Huiquan Lou (U of Manitoba) “Modulation of Mitogen-Activated Protein Kinases by Probucol in Doxorubicin-induced Heart Failure”

14. Marc Mikhael (McGill University) “The role of nitric oxide in iron metabolism; nitric oxide mediates specific increase of ferritin synthesis independently of iron regulatory proteins”

15. Guangjun Nie (McGill University) “Overexpression of mitochondrial ferritin induces apparent iron starvation and changes cellular iron distribution”

16. Natasha Szuber (McGill University) “Iron chelators Improve the pathophysiology of beta-thalassemic erythrocytes in vitro and in vivo”

17. Jian Wang (McGill University) “New insights into the molecular mechanism for iron-mediated degradation of iron regulatory protein 2”

7:30PM Banquet in Alumni Hall at Victoria College

SUNDAY, May 23rd

Session IV: Mitochondrial Toxicity and apoptosis

Chair: Pawan Singal

8:00-8:30 Jeff Henderson (Faculty of Pharmacy, U of T) “Roles of oxidative stress in neurodegenerative forms of programmed cell death”

8:30-9:00 Peter Pennefather (Faculty of Pharmacy, U of T) “Contribution of mitochondria to brain oxidative stress”

9:00-9:30 Diana Averill (Université du Québec á Montréal) “Induction of apoptosis by heat shock: relevance to cancer.”

9:30-10:00 George Cherian  (Department of Pathology, UWO) “Potential role of p53 on differential regulation of signal transduction pathways by copper and zinc”

10:00-10:15 Coffee/Tea Break

SUNDAY, May 23rd

Session V:  Trainee Presentations

Chair: Arno Siraki

10:15-10:30 Feng Wu (Department of Physiology, UWO) “NADPH oxidase activity is required for iNOS induction in LPS and INFgamma- stimulated mouse skeletal muscle endothelial cellssion”

10:30-10:45   Andre Tanel (Université du Québec á Montréal) “Role of caspase activation in
   apoptosis induced by the aldehyde acrolein”

10:45-11:00     Harjot K. Saini (U of Manitoba) “Role of Oxidative Stress in Ca2+-
 handling by Cardiomyocytes in Ischemia-Reperfused Hearts”

11:00-12:00  Poster Session III

Poster Session III

18. Ahmed Bettaieb (Université du Québec á Montréal) “Thermotolerance protects cells against apoptosis induced by oxidative stress and heat shock”

19. Chris Feeney (U of T) “A cuvette-based fluorometric analysis of  mitochondrial membrane potential measured in cultured astrocyte monolayers”

20. Ingrid Goh (U of T) “Assessment of the Effectiveness and Cost-Effectiveness of Vitamin C and E for the Prevention of Fetal Alcohol Syndrome in Alcohol Exposed Pregnancies and Fetal Alcohol Spectrum Disorders”

21. Ping Han (U of T) “Free Fatty Acid-induced Hepatic Insulin Resistance: Evidence for a Protein Kinase C-delta, Oxdiative Stress, IKKbeta and Insulin Receptor Substrates signaling pathway”

22. Osamu Handa (UWO) “Septic Plasma Induces Activation of Nuclear Factor kappa B in Astrocytes: Role of NO and Oxidant Stress”

23. Garth Oakes (UWO) “Bilirubin mediated apoptosis is characterized by the production of ROS, mitochondrial depolarization and Initial Caspase-9 activation in Hepa1c1c7 cells”

24. Andrei I. Oprescu (U of T) “The antioxdiant taurine prevents lipotoxicity on beta cell function in vitro and in vivo”

25. E.A. Ostrakhovitch (UWO) “Release of AIF and apoptosis in epithelial breast cancer cells after exposure to copper are dependent on p53 status”

26. Y.P. Song (UWO) “Metallothionein and apoptosis in MCF-7 cells after p53 knockdown by siRNA”

12:00PM Closing Remarks and End of Conference
 
 

1 Spadina Crescent, BCIT, King's College Circle are the closest locations to
the Earth Sciences Centre (where the meeting is going to be held) and New
College Residence.  The Parking rates are: Weekdays: $14.00 Maximum
Weekends and evenings: $5 flat rate.

Here is a map of the University of Toronto that should also be linked to the
website: http://www.osm.utoronto.ca/map/

This is the exact address for the Earth Sciences Centre
Earth Sciences Centre (ES)
Room Number 1050
33 Willcocks Street
M5S 3B3

Registration and abstract submission deadline: Friday, April 2nd, 2004

Copy the information between dotted lines below into a file, fill it in and e-mail it as a one 8.5 x 11 inch page with 2 inch margins all around.  Please e-mail it as a PDF file (MS word if PDF not possible) to oxidative_stress@hotmail.com

In addition to the e-mail  FAX this page to Nandita Shangari's Attention at 416-978-8511
(or mail two copies to Nandita Shangari c/o Dr. Peter J. O'Brien Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, Room 522, 19 Russell Street, Toronto, ON., M5S 2S2,Canada)

Abstract should be a maximum of 250 words. Each abstract should contain a sentence stating the study objective (unless given in the title); a brief statement of methods, if pertinent; a summary of the results obtained; and a statement of the conclusions.  It is not satisfactory to say, "the results will be discussed."  Use a short, specific title with upper and lower case letters.  Capitalize initial letters of trade names.  Use standard abbreviations for units of measure.  Other abbreviations should be spelled out in full at first mention, followed by the abbreviation in parentheses.  Exceptions: DNA, RNA, etc.  Include the source of research support on the bottom line of the abstract.
........................................................................................................................................................
Name:
Address:
Email:
Telephone:
Please circle one:
Will attend the May 21 (Friday) General Welcome:              Yes                        No
Will present a poster:         Yes ( if yes, please submit an abstract)                     No

Abstract Title: 4th Annual Oxidative Stress Consortium 2004
Author Names: Timothy Smitha and John Doeb
Affiliated University:  aDepartment of Pharmaceutical Sciences, University of Toronto and bDepartment of Biochemistry, McGill University.
                                 Abstract goes here
 
 
 
 
 
 
 
 
 
 
 

Funded By: Natural Sciences and Engineering Research Council of Canada
...................................................................................................................................................................................
 
 

Attendees: 17 students: 5   – McMaster, 11 – UofT, 1   – UWO
Presenters:  7 students: 1 – UWO,  2 – McMaster, 4 – UofT
  (3 – PhD students, 4 – undergraduate/summer students)
SUMMARY:
- Presentation time allocated (25 min) was sufficient to include the students’ presentation as well as questions/discussion.  We did not experience any technical difficulties with the presentations, which were brought by the students either on CD/floppy/ZIP disk drive formats.
- All students used PowerPoint for their presentations.
- Some of the undergraduate students commented that they were more confident in presenting to a student audience, as they liked the absence of professors.
- As meeting organizers/chairs, we ensured that questions were asked to encourage other students to feel at ease to ask questions themselves.
- The students liked the casual approach.
- Since half or more of the presenters were undergraduates, this venue was conducive for students starting out in research.
- The pub – as an agenda item – was useful in allowing the students to convey their thoughts.
- Although it was held on Thursday, some suggested Wednesday, Monday, or Friday.
- They generally felt as though they had learned something.
- The short time and small meeting were also liked.
- Pictures were taken and will be added to the website along with a meeting summary.

Yours truly,
Arno G. Siraki
Tom S. Chan
Giuseppe Galati
 
 

Local Organizing Committee:
Bernhard H.J. Juurlink (Chair), Joan Bobyn, Marina Facci, Huse Kamencic, Ed Krol, Hossein Noyan, Phyllis Paterson, Elisabeth Schültke

The objective of this meeting is to bring together a multidisciplinary group of Canadian basic scientists and clinical investigators, to discuss recent advances in mechanisms of oxidative stress and biological responses, and to plan research collaborations. The on-campus conference centre provides lecture halls, conference rooms and meals. This highly interactive setting encourages both formal and informal meetings and discussions. Abstracts of this year's talks and posters will be made available to all registrants, forming a permanent record of the proceedings.

There is no registration fee or charge for lunches and suppers for Principal Investigators (members) of the Consortium on Oxidative Stress, their graduate students and fellows. The registration fee (includes lunches and suppers) for other attendees is $400, payable to the University of Saskatchewan – Consortium on Oxidative Stress.  All attendees are responsible for arranging and paying for their own accommodation. Use the housing reservation form posted on the Consortium web page to reserve accommodation at the campus conference centre.

There are several hotels near the university. Here are some of them
Park Town Hotel
924 Spadina Crescent East
Saskatoon, Sask. S7K 3H5
Tel: (306) 244-5564
Fax: (306) 665-8698
Property direct reservations: 1-800-667-3999
E-mail: reservations@parktownhotel.com

Delta Bessborough
601 Spadina Crescent East
Saskatoon S7K 3G8
Phone: 306-2445521
Fax: 306-6657262

SHERATON CAVALIER HOTEL
612 SPADINA CRESCENT EAST
SASKATOON, SASKATCHEWAN S7K 3G9
306)652-6770

Radisson Hotel Saskatoon
405 20th St E,
Saskatoon, SK S7K 6X6
Phone: (306)665-3322
 

TRAVEL ASSISTANCE FOR CONSORTIUM MEMBERS (Faculty, staff and trainees)
For those coming from Manitoba and Edmonton,  $200 per registrant for first 15 registered. For those coming from any other part of the country,  $300 per registrant for first 30 registered.  No travel assistance for those coming from Saskatchewan.  A cheque for the travel assistance will be mailed to you after the meeting.
Click for  directions to University of Saskatchewan.
 
 

THURSDAY, MAY 2

6:00-9:00 pm: General Welcome (food plus cash bar)
8:00-11:00-pm Students/PDF Bash
Location: EXETER ROOM, Marquis Hall

Meeting Sessions will be in Arts 143 of the Arts Building

FRIDAY, MAY 3

MORNING
Session I: Metals and the Role of Oxidants in Cell Signalling
Chair: Phyllis G. Paterson

8:30: Introductory Remarks and Welcome.  Bernhard H.J. Juurlink and Ashok Grover

8:40: Overview of Some Oxidative Stress Pathways.  Bernhard H.J. Juurlink, Department of Anatomy & Cell Biology, University of Saskatchewan

9:00: Studies on iron-dependent degradation of IRP2.  J. Wang and Kostas Pantopoulos, Lady Davis Institute for Medical Research, McGill University

9:30: The role of oxidative stress in the toxicity of pyridoxal isonicotinoyl hydrazone (PIH) analogs.  Joan L. Buss, J.Neuzil and P. Ponka, Lady Davis Institute for Medical Research, McGill University

9:45: Modulation of mitochondrial membrane potential and reactive oxygen species production by copper in astrocytes.  A.V. Gyulkhandanyan, C.J. Feeney and Peter S. Pennefather, Department of Pharmaceutical Sciences, University of Toronto

10:00:  Coffee Break

10:30: Metallothionein, an anti-oxidant.  George Cherian, Department of Pathology, University of Western Ontario

11:00: Copper-induced oxidative and apoptosis in Long Evans rats.  Rudolfo Nino-Fong, C. Fuetealba and M.G. Cherian, Department of Pathology, University of Western Ontario

11:15: Implication of receptor/store operated calcium (ROCS/SOCS) channels in non-receptor bound iron uptake in neuronal cells.  James Mwanjewe and A.K. Grover, Department of Medicine, McMaster University

11:30: The Canadian Light Source.  Colleen Christensen, Project Manager, Biomedical Imaging Group

12:00-1:00 p.m. Lunch

1:00: Tour of the Canadian Light Source

AFTERNOON
Session II: OxiStress and Cardiovascular Disease
Chair: Ed Krol

2:30: Gases and oxidative stress in the cardiovascular system – Rui Wang, Department of Physiology, University of Saskatchewan

3:00: Hypercholesterolemic atherosclerosis and oxidative stress.  Kailesh Prasad, Department of Physiology, University of Saskatchewan

3:30: Ascorbate recycling in coronary artery - a developing story.  Ashok Grover, McMaster University

4:00: The effect of a phase 2 enzyme inducer in the stroke-prone rat.  Lingyun Wu, M.H. Noyan Ashraf, R. Wang, P.G. Paterson and B.H.J. Juurlink, Department of Anatomy & Cell Biology, University of Saskatchewan

4:15: Visit Wanuskewin Heritage Park

EVENING
7:00: Dinner at Marquis Hall

8:30: Program Session Workshop: Ashok Grover
 

SATURDAY MAY 4

MORNING
Session: III:  Metabolic Aspects of Oxidative Stress
Chair: Ashok Grover

8:30: Role of hyperhomocysteinemia in the development of atherosclerosis.  Ji Zhou,  G.H. Westuck, L. Watson, G.S. Hossein, A.B.L. de Koning, Y.Y. Shi, S.K. Sood and Rick Austin, Henderson Research Centre, McMaster University

9:00 a.m.  Oxidative stress polymorphisms that affect cell susceptibility to drugs.  Peter O’Brien, Department of Pharmaceutical Sciences, University of Toronto

9:30: Enhancing CoQ antioxidant strategies.  Tom S. Chan and P.J. O’Brien, Department of Pharmaceutical Sciences, University of Toronto

9:45: The role of metabolism in flavonoid/polyphenolic antioxidant strategies.  Giuseppe Galati, T.S. Chan, O. Sabzevari and P.J. O’Brien, Department of Phramacology, University of Toronto

10:00:  Involvement of reactive oxygen species in the toxicity/carcinogenicity of nitroaromatic/quinone urban air toxins and idiosyncratic drugs.  Arno G. Siraki and Peter J. O’Brien, University of Toronto, Dept. of Pharmaceutical Sciences,

10:15:  Coffee Break

10:45: Ascorbate inhibits inducible nitric oxide synthase expression in cell cultures and animal models of sepsis.  J.X. Wilson, F. Wu and K. Tyml, Departments of Physiology and Medical Physics, University of Western Ontario

11:15:  Genetic engineering using SOD to enhance stress tolerance in crops.  Larry Gusta, Crop Development Centre, University of Saskatchewan

11:45: Protection against oxidative stress by polyphenolic natural products.  Ed Krol, College of Pharmacy & Nutrition, University of Saskatchewan

12:15: Lunch

AFTERNOON
Session IV: Neurotoxicity and Neurodegenerative Diseases
Chair: Peter O’Brien

1:15:  Synchrotron IR Spectromicroscopy of Alzheimer diseased brain tissue.  K. Gough, Department of Chemistry, University of Manitoba

1:45:  Effects of oxidative stress and inhibitors on astrocyte mitochondrial membrane potential.  A.V. Gyulkhandanyan, C.J. Feeney and Peter S. Pennefather, Department of Pharmaceutical Sciences, University of Toronto

2:00: The effect of chronic hypertension on the spinal cord of the spontaneously hypertensive rats and possible  intervention by dietary phase 2 enzyme inducers.  M. Hossein Noyan Ashraf and B.H.J. Juurlink, University of Saskatchewan

2:15: A flavonoid approach to treatment in acute spinal cord injury in a rat model.  Elisabeth Schültke, H. Kamencic, R.W. Griebel and B.H.J. Juurlink,  Department of Anatomy & Cell Biology, University of Saskatchewan

2:30: Trauma involving head injury results in greater body oxidative stress than those involving spine injury.  Adebola O.E. Obayan, R.G. Keith, R.W. Griebel and B.H.J. Juurlink, Department of Anatomy & Cell Biology, University of Saskatchewan

2:45:  POSTER SESSION:  A301, Health Sciences Building

P1.  Engineering enhanced glial antioxidant response protects neurons in in vitro models of stroke damage.  A.Y. Shih, G.W. Wong, L. Jiang and T.H. Murphy, Kinsmen Laboratory of Neurological Research, University of British Columbia

P2. Effect of peroxynitrite on Ca2+-pumps in pig coronary artery smooth muscle.  Sue E. Samson, C.Y. Kwan and A.K. Grover, McMaster University

P3.  Administration of procysteine compound (OTC) decreases the number of activated macrophages/microglia following spinal cord injury.  Huse Kamencic, E. Matshes, M. Kelley, R.W. Griebel, P.G. Paterson and B.H.J. Juurlink,  Department of Anatomy & Cell Biology, University of Saskatchewan

P4.  Acute phase proteins and phase 2 enzyme inducers.  Marina Facci and B.H.J. Juurlink,  Department of Anatomy & Cell Biology, University of Saskatchewan

P5.  Induction of apoptosis by acrolein.  André Tanel and D.A. Averill-Bates, Département de chimie et biochimie, Université du Québec à Montréal

P6.  The ameliorating effect of broccoli sprouts on inflammatory changes in the hepatic tissue of the stroke-prone spontaneously hypertensive rats.  Zahra Sadeghinejad, L Wu, MH Noyan Ashraf, BHJ Juurlink.  Department of Anatomy & Cell Biology, University of Saskatchewan

P7.  Potential role of p53 on metallothionein induction in human epithelial breast cancer cells.  L. Fan and M.G. Cherian, Department of Pathology, University of Western Ontario

6:30 p.m. -  Banquet at Marquis Hall

SUNDAY, MAY 5

MORNING
8:30: Workshop I:  Kathleen Gough.  Synchrotron Infrared Spectroscopy and Imaging

10:30: Workshop II:  Stroke Models.   Phyllis G. Paterson, Jim A. Thornhill and Wolfgang Walz, University of Saskatchewan

AFTERNOON
1:30: Workshop III: Synchrotron X-ray Analysis and Imaging of Metals.  Helen Nichol, Stanford University

3:30: Workshop IV:  Neurotrauma Models.  Huse Kamencic and Elisabeth Schültke, University of Saskatchewan

Sunday Evening Free

Each Consortium member who pre-registers may give a presentation (e.g., platform talk). Fellows and students, from the laboratories of Consortium members, are invited to pre-register and present one poster/platform session. Poster boards are 8' wide x 4' high. The  deadline for receipt of Abstracts for oral and poster presentations is April 19.

PRE-REGISTRATION AND ABSTRACT SUBMISSION:

Copy the information below into an MS Word file, fill it in and e-mail to juurlink@duke.usask.ca
Also  FAX it to Bernhard H.J. Juurlink at 306-966-4298 or mail two copies to
Bernhard H.J. Juurlink
Department of Anatomy & Cell Biology
107 Wiggins Road
University of Saskatchewan
Saskatoon, SK, S7N 5E5

Name:
Address:
Email:
Telephone:

Will attend the May 2 (Thursday) General Welcome (Yes/No):
Will attend the May 5 (Sunday) Workshops (Yes/No):

If  presenting abstract, give title and abstract as shown below.
Abstract title:
Preferred sessions (please list at least 2 in order of decreasing priority) for your presentation (this information is requested from Consortium members only):
Supervisor’s name (this information is requested from fellows and students of Consortium members):

ABSTRACT FORMAT:
Camera ready, one page (8.5 x 11"), 2" margins for all 4 edges.
Heading style is:
HYPOTHALAMIC RESPONSES TO FRONTAL LOBE EXERCISE WITH THESIS COMPLETION AND ARRIVAL OF SUMMER
Palidus G, Amygdala L, Pleasure T
Teaching & Research Dept, U of Science, Growth, ON, 1A1 A1A
 
 

Oxidative Stress and Circadian Rhythms - check out these papers in Science
Redox Around the Clock: Science 293: This week in Science
      Circadian rhythms are controlled by an evolutionarily conserved transcriptional feedback system whose activity
      fluctuates as a function of the 24-hour light-dark cycle. Extrinsic factors, such as changes in food intake, can
      advance or delay the circadian clock, but the mechanism by which this "entrainment" occurs remains unclear. A
      key regulator of circadian rhythms, Clock, is expressed in the suprachiasmatic nucleus (the brain region
      regarded as the master pacemaker) and regulates the expression of genes encoding other clock components.
      Reick et al. (p. 506) and Rutter et al. (p. 510; see Perspective by Schibler et al.) show that the NPAS2
      transcription factor performs a function similar to Clock in the mammalian forebrain and that the DNA binding
      activity of both these transcription factors in vitro is regulated by the redox state of NAD (nicotinamide adenine
      dinucleotide) cofactors. Because changes in food intake are associated with changes in cellular redox state, the
      authors propose that redox control of Clock and NPAS2 a>

Transfer interrupted!

Lunch at the Phoenix (11:30am) will be provided, as well as snacks and parking.

Please enter McMaster campus at the Sterling Street entrance in West Hamilton and inform the parking attendant that you are here for the trainee meeting of the oxidative stress consortium.

Objectives:
To provide an informal setting for trainees to discuss aspects of their research, their experiences in graduate school and future career plans. This meeting is an excellent opportunity for trainees to initiate collaborations in other laboratories.

Please note: As this meeting is intended for trainees, faculty members wishing to attend may do so only as observers.

Current Speakers:

Rina Daskalopoulos (UWO), Marina Frantseva (UTOR), Chris Feeney (UTOR), Tom Preston, (MAC), Arno Siraki (UTOR), Showkat Hossain (MAC), Christine Misquitta (MAC)

If you are interested in presenting and/or attending, please inform your respective area captain:

University of Toronto
Arno Siraki <arno.siraki@utoronto.ca>
Tom Chan <chanto@hotmail.com>

University of Western Ontario
Rina Daskalopoulos <rina.daskalopoulos@med.uwo.ca>

McMaster University
Christine Misquitta <misquitt@mcmaster.ca>

or contact Lawrence de Koning
<ldekoning@thrombosis.hhscr.org>, student co-ordinator.

Oxidative Stress and Circadian Rhythms - check out these papers in Science (Click here)
First Trainee Meeting of the Oxidative Stress Consortium  Held on Aug 22, 2001 (Click to see announcement)

Trainees's Thoughts on Report of Oxidative Stress Consortium Web Site
Trainees discussed in the Aug 22 trainee meeting in Hamilton as to what the trainees would like to see on the Oxidative Stress Web site.  Here is the report prepared by two of them (Tom and Arno).  I would like to see discussion on this report and means of implementing it on the Bulletin Board.

1.) Trainee information.
     The trainees wish to have a presence on the web site including laboratory, publications, project title/research area, and techniques used in their research project and contact information.
2.)  Web site protocols.
The trainees generally think that this is a bad idea – too much information.  What you already have on the website is enough.  However, there should be a section which describes the work of each trainee including what techniques they use.  This information of course is provided by the trainee.  For example,
Trainee: John Smith
Supervisor: Professor X
Project title / Research Area: Adrenal Medulla and Medulla Oblongata
Techniques used:   Intra- and Extracellular glutathione assay
    Western blots
Recent Publications: Journal of Oxidative Stress v1(1):1-5 (2001)
Contact Info: e-mail, tel.

3.)  Reference Manager
The trainees also wouldn’t mind using Reference Manager to access the list of articles published by the oxidative stress consortium (those who do not own Reference Manager can buy it if they so wish).  Therefore it is unnecessary to have a complicated search engine for finding articles associated with members of the oxidative stress consortium.  No definite       answer was given by the meeting regarding this topic.
4.) PI Information.
Having the PI fill out updated forms describing their research interests and expertise during registration for the meetings is an excellent idea.  Information about the trainees can also be provided.
Overall

The trainees want the website to be a portal of communication between each other.  Collaborations between PIs could just as easily result from discussions between trainees.