McMaster University

McMaster University

Scott Gallichan,

PhD, BSc (Hons)

Assistant Professor (Part-Time)
Pathology and Molecular Medicine

Director of Immunology for Analytical Testing
Sanofi Pasteur, North America

Sanofi Pasteur
1755 Steeles Avenue West
Toronto ON
Tel: 416-667-2445
Fax: 416-667-2744
Email: Scott.Gallichan@sanofipasteur.com

photo of Dr Gallichan

Faculty Biography

Education and Professional Standing

PhD, Dept. of  Biology, McMaster University, 1996

BSc Hons, Biochemistry, University of Waterloo, 1989


Interests

Research Focus

Immunology; immunopathology; vaccinology; mucosal immunology; systems vaccinology; disease models and mechanisms of action for protective immunity; functional in vitro assays for monitoring potency; 3Rs. Director of Immunology for analytical testing for Sanofi Pasteur, North America. Focused on developing innovative immunological testing approaches using state of the art technologies to better understand and characterize vaccine products in clinical development and post licensure. Responsible for characterization and testing clinical material for release and use in clinical trials of new vaccines under development.  Products under development include recombinant protein vaccines for bacterial or viral targets as well as attenuated viruses, viral vectors and recombinant monoclonal antibodies.

Teaching Focus

Graduate and undergraduate courses including MS717-Advanced Immunobiology and MS717-Vaccines and Vaccine Immunology


Selected Publications

Gallichan, W.S., David C. Johnson, Frank L. Graham, Rae Lyn Burke and Kenneth L. Rosenthal. Mucosal Immunity and Protection after Intranasal Immunization With  Recombinant Adenovirus Expressing Herpes Simplex Virus Glycoprotein B. 1993. J. Inf. Dis. 168, 622-629.

Gallichan W.S. and Rosenthal K.L  Specific secretory immune responses in the female genital tract following intranasal immunization with a recombinant adenovirus expressing glycoprotein B of herpes simplex virus. 1995. Vaccine. 13, 1589-1595.

Gallichan, W.S., Johnson, D.C., Graham, F.L., Rosenthal, K.L. Mucosal immunization with a recombinant adenovirus vector induces local and systemic immunity and protection from herpes simplex virus. Adv Exp Med Biol 1995;371B:1581-5

Gallichan, W.S. and Rosenthal, K.L. Long-lived Cytotoxic T Lymphocyte Memory in Mucosal Tissues Following Mucosal But Not Systemic Immunization. 1996 J. Exp. Med. 184, 1879-1890.

Gallichan, W.S. and Rosenthal, K.L. Effects of the Estrous Cycle on Local Humoral Immune Responses and Protection of Intranasally Immunized Female Mice against Herpes Simplex Virus Type 2 Infection in the Genical Tract. 1996. Virology, 224, 487-497.

Bramson, J., Hitt, M., Gallichan, W.S., Rosenthal, K.L., Gauldie, J. and Graham, F.L. Construction of a Double Recombinant Adenovirus Vector expressing a Heterodimeric Cytokine: In Vitro and In Vivo Production of Biologically Active Interleukin-12. 1996. Human Gene Therapy. 7:333-342.

Serreze, D.V., Gallichan, W.S., Snider, D.P., Croituru, K., Rosenthal, K.L., Leiter, E, H., Christianson, G, J., Dudley, M, E., and Roopenian, D, C.  MHC Class 1-Mediated Antigen Presentation and Induction of CD8+ Cytotoxic T-cell Responses in Autoimmune Diabetes-Prone NOD Mice. 1996. Diabetes 45:902-908.

Gallichan, W.S. and Rosenthal, K.L. L. Long-term immunity and protection against herpes simplex virus type 2 in the murine female genital tract after mucosal but not systemic immunization. J Infect Dis 1998 May;177(5):1155-61

Gallichan, W.S., Tal Kafri, Troy Krahl, Verma, I.M., Sarvetnick, N. Lentivirus-mediated transduction of islet grafts with interleukin 4 results in sustained gene expression and protection from insulitis. Hum Gene Ther 1998 Dec 10;9(18):2717-26.

Gallichan WS, Balasa B, Davies JD, Sarvetnick N. Pancreatic IL-4 expression results in Islet-reactive Th2 cells that inhibit diabetogenic lymphocytes in the nonobese diabetic mouse.  J. Immunol. 1999 Aug 1;163(3):1696-703

Braciak, T.A., Gallichan, W.S., Graham, F.L., Richard, C.D., Ramsay, A.J., Rosenthal, K.L., and Gauldie, J. Recombinant human adenovirus expressing interleukin 5 and 6 synergistically enhance mucosal IgA responses in the lung.  Immunology 101:388-396, 2000

Gallichan, W., Scott, Woolstencroft, R, Guarasci, Tina, R., McCluskie, Michael, J., Davis, Heather, L. and Rosenthal, Kenneth, L. Intranasal Immunization with CpG ODN dramatically increases IgA and protection against HSV-2 in the Genital Tract. J.Immunol. 2001, 166:3451-3457.

Radvanyi L, Singh-Sandhu D, Gallichan S, Lovitt C, Pedyczak A, Mallo G, Gish K, Kwok K, Hanna W, Zubovits J, Armes J, Venter D, Hakimi J, Shortreed J, Donovan M, Parrington M, Dunn P, Oomen R, Tartaglia J, Berinstein NL. The gene associated with trichorhinophalangeal syndrome in humans is overexpressed in breast cancer. Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11005-10. Epub 2005 Jul 25.

Salha D, Szeto J, Myers L, Claus C, Sheung A, Tang M, Ljutic B, Hanwell D, Ogilvie K, Ming M, Messham B, van den Dobbelsteen G, Hopfer R, Ochs MM, Gallichan S. Neutralizing antibodies elicited by a novel detoxified pneumolysin derivative, PlyD1, provide protection against both pneumococcal infection and lung injury.Infect Immun. 2012 Jun;80(6):2212-20.
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