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Smaller TextAndrew Don-Wauchope
MB.BCh, MD, FRCP Edin, FCPath, FRCPath, FRCPC
Associate Professor
Pathology and Molecular Medicine
Division: Clinical Pathology
Director, Medical Biochemistry Residency Program
Clinical Chemistry/Clinical Immunology Service (HRLMP)
Associate Member, Department of Pediatrics
Associate Member Department of Medicine (Endocrinology)
Juravinksi Hospital Cancer Centre
Section A, Level 0, Room 120
Hamilton Ontario
Tel: 905-527-4322 x 76306
Fax: 905-381-7066
donwauc@mcmaster.ca
Faculty Biography
Education and Professional Standing
FRCP Edin, Royal College of Physicians of Edinburgh, 2009
FRCPath, Royal College of Pathologists, 2008
FRCPC Medical Biochemistry, 2007
MRCPath, Royal College of Pathologists, 2005 DipRCPath, Royal College of Pathologists, 2005
FCPath (Chem), South African College of Medicine, 2005
MD, University of Edinburgh, Scotland, 2005
MRCP, Royal College of Physicians of Edinburgh, 2002
BSc Med (Hons) Epidemiology and Biostatistics, University of Cape Town, South Africa, 1994
MB.BCh, University of Witwatersrand, South Africa, 1990
Interests
Research Focus
Utilization of Laboratory Diagnostic Tests
The need to develop an evidence base for the use of diagnostic tests in clinical laboratory medicine is essential to the future use of these tests. In conjunction with McMaster Evidence Review and Synthesis Centre (MERSC) we conduct systematic reviews of selected diagnostic tests to establish evidence for their use in clinical practice. Related to this is the use of laboratory tests in clinical practice guidelines(CPG). We are exploring projects to evaluate the quality of these guidelines with respect to the laboratory component.
Translational Research in Laboratory Medicine
The physiology/biology laboratory often produces ideas that can be moved into the clinical arena. This research relates to the need to establish new biomarkers to assist clinicians in predicting the diagnosis of metabolic disease (such as type 2 diabetes) at an earlier stage than what the current diagnostic testing allows. To do this a combination of techniques are proposed to identify appropriate markers and combinations of markers that will allow predictive assessment of disease or dysfunction of metabolic process. The techniques we are using include animal models, physiological studies in humans, proteomic and metabolomic analysis of tissue and serum, LC-MS-MS analysis of steroid and peptide hormones along with the more traditional chemistry analysis by spectrophotometry and immunoassay. In the future we will need to develop computational models that utilize the data that is generated to model probability of disease or metabolic dysfunction.
Clinical Focus
Dr. Don-Wauchope has clinics at Hamilton Health Sciences where he consults patients referred with Lipidology and Cardiovascular disease prevention concerns. The use of laboratory diagnostics in clinical endocrinology is a particular specialised area of interest.
Academic Interests
Dr. Don-Wauchope is program director for the medical biochemistry residency training. He also teaches in the Residency Training Program, training post-graduate medical biochemistry residents and fellows as well as training general pathology residents. In addition he is currently involved in the Undergraduate Medical Program where he participates in curriculum review for the medical foundations, facilitating in the Professional Competency unit and tutoring clinical clerkships in paediatrics.
Selected Publications
S McDonald, E Pesarchuk, AC Don-Wauchope, H El Zimaity , AC Holloway. Adverse metabolic effects of a hypercaloric, high fat diet in rodents precede observable changes in body weight. Nutrition Research 2011 Sep;31(9):707-14. Sep 2011.
Y Huang, AC Don-Wauchope . The Clinical Utility of Kidney Injury Molecule 1 in the Prediction, Diagnosis and Prognosis of Acute Kidney Injury: A Systematic Review. Inflamm Allergy Drug Targets. 2011; 10: 260-271. May 2011.
D Armstrong , AC Don-Wauchope, EF Verdu. Testing for gluten-related disorders in clinical practice: the role of serology in managing the spectrum of gluten sensitivity. Can J Gastroenterol. 2011 Apr;25(4):193-7. Apr 2011.
AC Don-Wauchope, L Wang, V Grey. “Pediatric Critical Values: Laboratory-Pediatrician Discourse.” Clin Biochem. (2009) 42: 1658-1661.
AC Don-Wauchope, M Hoffmann, M le Riche, BH Ascott-Evans. “Review of the Prevalence of Macroprolactinaemia in a South African Hospital.” Clin Chem Lab Med (2009) 47: 882-884.
AC Don-Wauchope, DE Cole. “The (Mis) Use of Bone Resorption Markers in the Context of Bisphosphonate Exposure, Dental Surgery and Osteonecrosis of the Jaw.” Clin Biochem (2009) 42: 1194-1196.
AC Don-Wauchope AC, VT Chetty. “Laboratory Defined Critical Value Limits: How Do Hospital Physicians Perceive Laboratory Based Critical Values?” Clin Biochem (2009) 42: 766-770.
