Larger Text
Smaller TextMurray Potter
, MD
Associate Professor
Pathology and Molecular Medicine
Division: Clinical Pathology
Head, Biochemical Genetics
McMaster University
3N17 Health Sciences Centre
905-521-2100 ext. 73718
mpotter@hhsc.ca
Faculty Biography
Education and Professional Standing
- Fellow of the Canadian College of Medical Geneticists (FCCMG), 2002. Fellowship training program in Biochemical Genetics, McMaster University and University of British Columbia, 2000-2002
- Fellow of the Royal College of Physicians and Surgeons of Canada (FRCPC), 2000. Residency training in Medical Biochemistry, McMaster University, 1995-2000
- MD, Faculty of Medicine, University of Manitoba, 1995
- BSc (Medicine), University of Manitoba, 1993
- BSc (Biochemistry), University of Manitoba, 1991
Interests
Research Focus
The major focus of Dr. Potter’s research is on inborn errors of metabolism. This encompasses basic and clinical research in the treatment of these disorders and the development of diagnostic tests.
Dr. Potter’s basic research, in collaboration with Dr. Harald Stöver and Dr. Gonzalo Hortelano, centres on using implanted microencapsules containing engineered cells for medical therapeutic applications (see Microencapsulation Gene Therapy).
Dr. Potter’s clinical research encompasses the development of new/improved diagnostic and monitoring tests for inborn errors of metabolism as well as clinical trials testing new therapies for inborn errors of metabolism.
Clinical Focus
Dr. Potter spends most of his professional time in the area of biochemical genetics, either running Metabolic Genetic clinics at McMaster Children's Hospital, or directing the Biochemical Genetics Laboratory at the Hamilton Regional Laboratory Medicine (see Clinical and laboratory biochemical genetics ). He is also head of the regional newborn screening follow-up program.
Academic Interests
Dr. Potter teaches undergraduate students in the Bachelor of Health Sciences Program, medical students, and post-graduate trainees in the pathology and paediatrics residency programs. He is also a member of the national governing bodies of the specialty committees and examination committees in medical biochemistry (Royal College of Physicians and Surgeons) and biochemical genetics (Canadian College of Medical Geneticists).
Team Members
Administrative Assistant: Kerry Arnett
Technologists: Karen Rendall, Alan Rutherford, Donna McCaughey, Jeannette Pearce
Manager: Dan Brooks
Physicians: Dr. Murray Potter, Dr. Mariya Kozenko
Genetic Councillors: Lauren Brick, Christina Paradiso
Dietitian: Amy Pender
Social Work: Jennifer Thomas
Selected Publications
Abstracts
Shawli A, Brick L, Potter MA. Abstract – Minocycline– induced hyperpigmentation misdiagnosed as Alkaptonuria in a patient with ochronosis. Molecular Genetics and Metabolism 2009;98(1-2)p139.
Lambourne M, Potter MA. Abstract – Construction of brain-targeted murine &[beta]-galactosidase for application in the treatment of GM1 gangliosidosis: Mouse enzyme less susceptible to proteolytic degradation than human enzyme. Molecular Genetics and Metabolism 2009;98(1-2)p67.
Khan A, Holland J, Brick L, Pender A, Potter MA. Abstract – Glutamate dehydrogenase deficiency due to a GLUD1 mutation presenting with hyperammonemia and growth hormone deficiency without hyperinsulinism. Molecular Genetics and Metabolism 2009;98(1-2)p129.
Schwindt JM, Potter MA. Abstract – Brain-targeted therapy for mucopolysaccharidosis type II delivered by microencapsulated recombinant cells. Molecular Genetics and Metabolism 2009;98(1-2)p84.
Pender A, Brick L, Potter MA. Abstract – Symptomatic Maternal 3-Methylcrotonyl-CoA Carboxylase Deficiency Ascertained from Newborn Screening. Molecular Genetics and Metabolism 2009;98(1-2)p127.
Hou DY, Potter MA. Abstract – Microencapsulated brain-targeted therapy for Metachromatic leukodystrophy. Molecular Genetics and Metabolism 2009;98(1-2)p83.
Howarth BS, Hou DY, Potter MA. Abstract – In vitro effect of NB-DGJ on arylsulfatase-A deficient fibroblasts. Molecular Genetics and Metabolism 2009;98(1-2)p60.
Book Chapters
Khan A, Potter M. Inborn errors of metabolism in Manual of Pediatric Intensive Care (Eds. Kirpalani H, Huang L, Duffet M and Michenko M). 2009 PMPH/BC Decker.
Potter M, Li A, Shen F, Chang P. Microencapsulation for the treatment of lysosomal storage disease. The Bioartificial Endocrine Pancreas and Other Biohybrid Therapies (Eds. Halle J, de Vos P and Rosenberg L). 2009 Research Signpost.
Mazumder JMA, Burke NAD, Shen F, Chu T, Potter MA, Stöver HDH. Synthetic Reactive Polyelectrolytes for Cell Encapsulation. Polymeric Delivery of Therapeutics, Chapter 7, 2010, pp 131-159. ACS Symposium Series, Volume 1053.
Papers
Shen F, Mazumder MAJ, Burke NAD, Stöver HDH, Potter MA. Mechanically enhanced microencapsules for cellular gene therapy. Journal of Biomedical Materials Research: Part B - Applied Biomaterials 2009, 90(1):350-61.
Mazumder MA, Shen F, Burke NA, Potter MA, Stöver HD. Core-crosslinked alginate microcapsules for cell encapsulation. Biomacromolecules 2009, 10(6):1365-73.
Li AA, Hou DY, Shen F, Seidlitz E, Potter MA. Luciferase therapeutic microcapsules for gene therapy. Artificial Cells Blood Substit. Immobil. Biotechnol. 2009, 37(6):235-44.
Bercik P, Verdu EF, Foster JA, Macri J, Potter M, Huang X, Malinowski P, Jackson W, Blennerhassett P, Neufeld KA, Lu J, Khan WI, Corthesy-Theulaz I, Cherbut C, Bergonzelli GE, Collins SM. Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice. Gastroenterology. 2010 Dec;139(6):2102-2112.
Gardner CM, Burke NA, Chu T, Shen F, Potter MA, Stöver HD. Poly(methyl vinyl ether-alt-maleic acid) Polymers for Cell Encapsulation. J Biomater Sci Polym Ed. 2011; 22(16):2127-2145.
Lambourne MD, Potter MA. Murine β-galactosidase stability is not dependent on temperature or protective protein/cathepsin A. Mol Gen Metab. 2011 Dec;104(4):620-6.
Gardner CM, Potter MA, Stöver HD. Improving covalent cell encapsulation with temporarily reactive polyelectrolytes. J Mater Sci Mater Med. 2011 Dec 17. [Epub ahead of print]
