The following major research centres have been recognized for their substantial contribution to research activity at McMaster University and beyond. Members of the Department of Pathology and Molecular Medicine are affiliated with these centres and work in collaboration to conduct research on a wide array of topics. For additional information, click on any centre name.
Institute of Infectious Disease Research
… conducts bench-to-bedside research in intestinal diseases. This approach allows program to bring new insights from the laboratory to improve the care of patients. Research is primarily conducted under the following themes: Immunophysiology; Enteric Infection-Mucosal Immunology; Gut-Brain Interactions; Pathology of interstitial cells of Cajal. Physiology-Pharmacology; Clinical Research-Therapeutic Trials. The themes represent overlapping areas of research interests, with some IDRP researchers working in more than one theme area. They form the basis of an integrated research program in the area of gut (dys-) function
Farncombe Family Digestive Health Research Institute
… is an integrated group of clinical and basic scientists dedicated to understanding the impact of digestive health and nutrition on disease across the life span. The Institute is focused on developing new strategies for diagnosis, treatment and prevention of intestinal diseases such as Crohn’s disease and ulcerative colitis, which will have global benefits. However, the focus of research in the Institute is not limited to digestive diseases; rather, it includes diseases of many other organ systems that may be caused and/or profoundly influenced by digestive health and nutrition. Facilitated by an extraordinary $15 million donation from the Farncombe family, the Institute was established as an outgrowth of McMaster University's Intestinal Diseases Research Program, originally founded in 1983. The Farncombe Family's generous contribution has allowed by the establishment of endowed chairs and infrastructure capital, which will ensure the long-term success of the Institute and enhance its role as an innovative training environment. For more than 25 years, McMaster’s Intestinal Diseases Research Program has garnered an international reputation as one of the top 10 gastrointestinal research groups in the world. The growth in research funding, faculty awards and now with the expansion into a Research Institute is a testament of the critical role McMaster researchers are playing in the study of digestive disorders.
… is the gateway to state-of-the-art technology platforms for visualization and analysis of DNA, RNA, proteins and small molecules. McMaster University houses outstanding infrastructure that is available to both academic and non-academic users on a fee-for service basis. All facilities are staffed by experienced professionals who will help you plan and execute your projects to achieve your scientific goals. If desired, training on various platforms is available.
MOBIX (McMaster Institute for Molecular Biology and Biotechnology)
… is administered by a board composed of the directors of each of the following four centres:
Antimicrobial Research Centre
The field of infectious disease and antimicrobial therapy is being transformed at present by the growing availability of the complete genome sequences for several microbes including bacteria, fungi and protists. This information will drive the research of this Centre in the area of infectious diseases for the next several decades.
Centre for Evolutionary and Genomics Biotechnology
… the mission of the Centre is to provide automated tools to the study of environmental, evolutionary and genomics issues with the aid of modern biotechnology tools. With high throughput instruments, research in these fields can be accomplished at a faster rate, in greater depth and with greater precision. With these instruments we can analyze the consequences of and the changes in gene expression in organisms as a response changes within the environment. The purpose of the centre is to bring the power of the technologically revolutionary methods of genomics to bear on important environmental problems in biology.
Functional Genomics Centre
The field of functional genomics seeks to define the biochemical and biological functions of the protein products of genes on a genome-wide scale. The mission of the Centre is to develop new technologies and to exploit recent advances in gene expression profiling, bioinformatics and proteomics to discover gene function and to integrate this knowledge into genetic pathways that regulate organismal development and physiology. A major focus of our research is to use functional genomic technologies to identify new genetic markers and molecular therapeutic targets associated with human diseases.
McMaster Immunology Research Centre
… formerly the Centre for Gene Therapeutics, the McMaster Immunology Research Centre (MIRC) has undergone significant changes since Jonathan Bramson replaced Jack Gauldie as director in 2009. Under Dr. Bramson’s guidance, the faculty members associated with this research centre undertook a visioning exercise to define the future of the centre. As a result of this exercise, the faculty decided to focus on excellence in three areas: Immunology Research, Immunology Education and Immunology Service. The faculty members also proposed that the name of the research centre be changed to “The McMaster Immunology Research Centre” to better align with their defined goals. The new mandate and name of the research centre was approved in 2012. As the name would imply, the main focus of MIRC is research. Over these five years, MIRC faculty have garnered $50,028,203 in research funding from a variety of funding bodies, including both public and private sector interests. MIRC scientists published a total of 346 research manuscripts in leading journals. During this same period, MIRC faculty gave 385 invited lectures at a variety of local, national and international meetings and trained a total of 35 MSc students, 40 PhD students and 52 post-doctoral fellows.