Dr. Chan graduated from medical school at the University of Hong Kong in 1987. After an internship and brief training in Nuclear Medicine, he began his pediatric career in 1989 at the University of Hong Kong and, subsequently, at the University of Saskatchewan. Finally, Dr. Chan completed his clinical training in pediatric hematology and oncology at the Hospital for Sick Children in 1995. Dr. Chan joined McMaster University in 1997 and moved to The Hospital for Sick Children from 2000 - 2001. He rejoined McMaster University in July 2002.

Dr. Chan's main research interest is in the study of the hemostatic system in the young and hemostatic mechanisms related to pediatric diseases. Currently, Dr. Chan is developing a family of novel serpin-glycosaminoglycan covalent complexes. The study of these compounds will further understanding of the mechanisms of action of glycosaminoglycans (eg. Heparin) with serpins (eg. Antithrombin). These compounds are potentially useful in the treatment and prevention of diseases. Potential uses of these compounds includes coating of biomaterials to render them less thrombogenic and, thus, prevent some thromboembolic diseases. In addition to treatment of thrombosis with these novel anticoagulants, Dr. Chan has co-invented a methodology for monitoring thrombin generation potential in the patient samples. Dr. Chan is very involved with clinical research in pediatric thrombosis and hemophiia, and pediatric stroke. Dr. Chan works with the Canadian Pediatric Ischemic Stroke Registry, International Pediatric Stroke Study and Pediatric Thrombosis Program at the Hospital for Sick Children.

Dr. Chan's clinical focus is on children with bleeding and clotting disorders. He is the director of the Hamilton-Niagara Regional Hemophilia Program, and he also provides a free consultation services for physicians who look after children with thrombosis through a 1-800 number (1-800-NO-CLOTS). He is the division head for hematology/oncology in the Department of Pediatrics at McMaster University.