About Neuromuscular & Neurometabolics
Neuromuscular disorders affect approximately one person in 100 and include disorders of muscle, neuromuscular junction and peripheral nerve. Commonly recognized conditions would include muscular dystrophy, myasthenia gravis, ALS, peripheral neuropathy (including Guillain Barre syndrome).
Neurometabolic disorders are varied and include disorders of intermediary metabolism (fat, protein and carbohydrate) as well as disorders of the final common pathway for energy metabolism, the mitochondria. Neurometabolic conditions can result in muscle fatigue, cramps with exercise with severe muscle breakdown with or without enlargement of the heart (cardiomyopathy) and central nervous system disorders including seizures, strokes, developmental delay and /or regression.
There are a large number of tests that are required to diagnose the aforementioned condition that are available in our clinic including electromyography (EMG) and nerve conductions studies, lumbar puncture, muscle biopsy, strength testing, exercise testing, metabolic exercise testing, lung function and spirometry, body composition using DEXA and coordination of a large number of biochemical and genetic tests. These are all available as "one stop shopping" in our clinic.
The overall philosophy of the clinic is to provide comprehensive care for patients with neuromuscular and neurometabolic conditions from diagnosis through to rehabilitation. Our team includes a developmental pediatrician (Dr. Teresa Carter), a physiatrist (Dr. Judy Trotter), and a neuropsychiatrist (Dr. Anthony Levinson). With these physicians and the outstanding technical support from our neuromuscular technicians (Ms. Erin Pearce and Ms. Alissa Aboud) to our EMG technicians (Mrs. Henny Spoelstra and Mrs. Hilary Libbrecht). We also have an outstanding support team who coordinates all of these efforts (Ms. Dale Johnston, Mrs. Lena Westerink and Ms. Linda Martin). This helps to consolidate care in one area and simplify diagnosis and follow-up visits.
The Neuromuscular and Neurometabolic Clinic is intimately involved in research and we have a very strong wet laboratory component with biochemical, microscopic and genetic evaluation of patient muscle samples as well as a cell culture and animal program evaluating a number of animal models of human neuromuscular and neurometabolic disorders. There are a number of post doctoral fellows and graduate students who are involved in the clinical, translational and basic science research projects.
From a teaching perspective, we have two clinical fellowship positions filled every year and accommodate residents from neurology, physiatry, pediatrics and rheumatology for elective experience in neuromuscular and neurometabolic disease. We often have visiting professors completing sabbatical terms in our division.
Dr. Steven Baker
Assistant Professor, Neurology & Physical Medicine and Rehabilitation
Dr. Mark Tarnopolsky
Professor, Neuromuscular & Neurometabolic Disease
Dr. Teresa Carter, Developmental Pediatrician
Dr. Anthony Levinson, Neuropsychiatrist
Dr. Judy Trotter
Dr. Mark Tarnopolsky has received an Endowed Chair in Neuromuscular and Neurometabolic Disorders from the McMaster Children's Hospital, Hamilton Health Sciences Foundation Chair in Children's Health.
Dr. Steven Baker has received an Endowed Chair in Neuromuscular Disorders from the Hamilton Regional Assessment Centre.
We are currently involved in clinical trials in Friedreich's ataxia, statin myopathies, aging, Pompe disease, McArdle's disease mitochondrial disorders and muscle immobilization induced atrophy.