McMaster University

McMaster University

The Pedi FETCh Research Trial

The Pedi FETCh Research Trial: Pediatric Fecal Transplant for Ulcerative Colitis (FETCh)

The Pedi FETCh Research Trial (Pediatric Fecal Transplant for Ulcerative Colitis) is the first pediatric fecal transplant study for inflammatory bowel disease in Canada, and will be the first randomized controlled trial of fecal transplant in pediatric inflammatory bowel disease in the world. The trial is being lead by Dr. Nikhil Pai, and supported by the Division of Pediatric Gastroenterology and Nutrition at McMaster Children’s Hospital. Study collaborators include Dr. Christine Lee (Division of Infectious Disease at St. Joseph's Hospital in Hamilton), and Paul Moayyedi (Division of Adult Gastroenterology at McMaster University), with support from the Farncombe Digestive Disease Research Institute at McMaster University.

Donor Stool Source Information

  • Enemas are provided by Rebiotix® , a USA-based biotechnology company.
  • The Rebiotix® enema product has received approval for use by the US Food and Drug Administration and Health Canada, Clinical Trials Division.
  • Live human donor stool is used.
  • Donors are extensively prescreened with blood and stool-tested prior to administration.
  • The Pedi FETCh Trial has received full approval from Health Canada, and the Hamilton Integrated Reserach Ethics Board.
  • Study collaborators include members of the Division of Infectious Disease at St. Joseph’s Hospital, Hamilton, Ontario (Dr. Christine Lee) and Division of Adult Gastroenterology at McMaster University Medical Center (Dr. Paul Moayyedi).
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