McMaster University

McMaster University

The Pedi FETCh Research Trial

The Pedi FETCh Research Trial: Pediatric Fecal Transplant for Ulcerative Colitis (FETCh)

The Pedi FETCh Research Trial (Pediatric Fecal Transplant for Ulcerative Colitis) is the first pediatric fecal transplant study for inflammatory bowel disease in Canada, and will be the first randomized controlled trial of fecal transplant in pediatric inflammatory bowel disease in the world. The trial is being lead by Dr. Nikhil Pai, and supported by the Division of Pediatric Gastroenterology and Nutrition at McMaster Children’s Hospital. Study collaborators include Dr. Christine Lee (Division of Infectious Disease at St. Joseph's Hospital in Hamilton), and Paul Moayyedi (Division of Adult Gastroenterology at McMaster University), with support from the Farncombe Digestive Disease Research Institute at McMaster University.

Frequently Asked Questions

How is this study different from others?

Few pediatric fecal transplant studies have been done for IBD. Others have used within household donors, different routes of administration, or different frequency of administration.

When is this study going to start?

We have started recruiting patients.

What patients have “active disease?”

PUCAI score >10

What testing is occurring on enemas?

  • All donors are initially lifestyle screened,
  • Donor blood and stools tested initially for infectious disease,
  • Blood and stool held in quarantine x 45 days,
  • Blood and stool samples are retested and released if all tests return normal

Are patients outside of McMaster allowed to participate?

Yes. Patients will have to be registered as McMaster Children’s Hospital patients during the study period. Please ask your doctor to contact us, or a member of our study team can speak to you directly.

Can patients do the enemas at home?

All 12 enemas will be administered within the 3E McMaster Pediatric GI Clinic by trained research staff.This is to maintain viability and insure safety of the enema delivery technique.

What outcomes are being measured?

Our primary outcomes are measures of trial feasibility. Our secondary outcomes include changes in:bloodwork,PUCAI score,fecal microbiota (16s Sequencing), and fecal inflammatory markers.

Click here to download the Pedi FETCh FAQ Handout

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