McMaster University

McMaster University

The Pedi FETCh Research Trial

The Pedi FETCH Research Trial: Pediatric Fecal Transplant for Ulcerative Colitis (FETCh)

The Pedi FETCh Research Trial (Pediatric Fecal Transplant for Ulcerative Colitis) is the first pediatric fecal transplant study for inflammatory bowel disease in Canada, and will be the first randomized controlled trial of fecal transplant in pediatric inflammatory bowel disease in the world. The trial is being lead by Dr. Nikhil Pai, and supported by the Division of Pediatric Gastroenterology and Nutrition at McMaster Children’s Hospital. Study collaborators include Dr. Christine Lee (Division of Infectious Disease at St. Joseph's Hospital in Hamilton), and Paul Moayyedi (Division of Adult Gastroenterology at McMaster University), with support from the Farncombe Digestive Disease Research Institute at McMaster University.

How is this study different from other studies?

Few fecal transplant studies have been performed across North America or internationally for pediatric ulverative colitis or Crohn's disease. Earlier studies have used within household donors, different routes of administration, or different frequencies of administration.

This study is different in how it will use a unique, safety screened, human donor enema that is delivered over a 6 week period. This study aims to have the largest sample size ever recruited in a pediatric fecal transplant study for inflammatory bowel disease.

This is the first pediatric fecal transplant study in Canada, and will use a novel fecal transplant technique that has been used, and safety tested, in other trials around the world.

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