Division of Rheumatology


The research programmes have focused on areas of clinical interest. They include research in rheumatoid arthritis, osteoarthritis, osteoporosis. We have received major peer-reviewed and corporate funding in each of these areas of research. Our clinical trials expertise has led us to national and international prominence. In addition to funding of clinical trials in rheumatoid arthritis, we have been involved in a large database collecting information on osteoporosis. Our participation in The Canadian Multicentre Osteoporosis Study (CaMos), a random sample of 10,000 subjects from across Canada being followed for the development of fractures, has been successful and has resulted in another CIHR funded research project examining hip geometry as a risk for fracture. This study is in its tenth year of follow-up.

Our osteoporosis research extends across many specialties and programmes and, as a result collaboration has occurred with: geriatrics, in particular with Dr. Papaioannou (osteoporosis guidelines and adherence to therapy), respirology (osteoporosis in cystic fibrosis and COPD), physical medicine (bisphosphonates in spinal cord injury), kinesiology (physical therapy in spinal cord injury and in hip fractures in the elderly), and more recently with orthopaedics (bisphosphonates in hip fracture patients).

In collaboration with Dr. C. Webber we have introduced a basic component to our research that utilizes a variety of instruments for the measurement of bone mass and structure including: peripheral CT scan and MRI for the measurement of bone and cartilage structure. Expertise provided by Dr. Inglis and Dr. Gordon has advanced our ability to image bone and cartilage and in collaboration with Dr. Noseworthy, a bird cage MRI coil has been developed that further enhances our ability to image bone structure. In collaboration with Dr. J. MacGregor, from the school of engineering, we have developed a novel method of investigating those with knee pain differentiating osteoarthritis from and those with a mensical tear.

Dr. M. Larche is a new recruit to the division. She is interested in rheumatoid arthritis and some of the new imaging techniques that are being developed in Hamilton. In particular she has an interest in early RA and the prevention of erosions as imaged by MRI.

Dr. Kumbhare has collaborated with both the surgical and allied health professionals. With the surgeons he has examined biochemical measures of tissue injury following surgery and with the alllied health professional has been involved in numerous publications on physiotherapeutic interventions. Both Dr. Mathoo and Dr. Kumbhare have been cross appointed to the division of rheumatology to further promote collaborative research.

As a group we remain strong in the conduct of clinical trials in the areas of rheumatoid arthritis, osteoarthritis and osteoporosis.

Additionally, Drs Khalidi and Kaminska are members of the Canadian Scleroderma Research Group and are currently active in database collection and contributing nationally to the group effort of studies of Scleroderma that arise out of this data set.