McMaster University

McMaster University

Thomas Hawke

, PhD

Professor
Pathology and Molecular Medicine

Division: Anatomy
Associate Member: Biochemistry and Biomedical Sciences
Associate Member: Kinesiology

McMaster University
4N65 Health Sciences Centre
Tel: 905-521-2100 ext 22372
hawke@mcmaster.ca

Lab website

Currently accepting Graduate Students

Thomas Hawke

Faculty Biography

Education and Professional Standing

  • PhD Human Biology and Nutritional Sciences, University of Guelph 2000 
  • MSc Human Biology and Nutritional Sciences, University of Guelph 1996
  • BSc Human Kinetics, University of Guelph 1994

Interests

Research Focus

Dr. Hawke’s research focus is on the role and regulation of muscle satellite cells, the stem cell population of skeletal muscle, in health and disease states such as diabetes mellitus and limb girdle muscular dystrophy.

Using molecular, cellular and physiological techniques, we are attempting to define the regulation of this cell population in health and disease.Techniques used in the lab include: histology, immunohistochemistry, protein and RNA expression assays, isolated single fibre and primary myoblast cultures, in situ muscle stimulation to assess contractile function, adenoviral mediated overexpression and/or silencing and metabolic enzyme assays.

 


 

Selected Publications

  • Monaco CMF, Bellissimo CA, Hughes MC, Ramos SV, Laham R, Perry CGR, Hawke TJ.  Sexual dimorphism in human skeletal muscle mitochondrial bioenergetics in response to type 1 diabetes. Am J Physiol Endocrinol Metab. 2020 Jan 1;318(1):E44-E51.
  • Rebalka IA, Cao AW, May LL, Tarnopolsky MA, Hawke TJ. Statin administration activates system xC(-) in skeletal muscle: a potential mechanism explaining statin-induced muscle pain. Am J Physiol Cell Physiol. 2019 Nov 1;317(5):C894-C899.
  • Monaco CMF, Gingrich MA, Hawke TJ. Considering Type 1 Diabetes as a Form of Accelerated Muscle Aging. Exerc Sport Sci Rev. 2019 Apr;47(2):98-107.
  • Monaco CMF, Hughes MC, Ramos SV, Varah NE, Lamberz C, Rahman FA, McGlory C, Tarnopolsky MA, Krause MP, Laham R, Hawke TJ, Perry CGR. Altered mitochondrial bioenergetics and ultrastructure in the skeletal muscle of young adults with type 1 diabetes. Diabetologia. 2018 Jun;61(6):1411-1423.
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