McMaster University

McMaster University

Catherine P.M. Hayward


Pathology and Molecular Medicine

Division: Clinical Pathology

Associate Member, Medicine
Head, Coagulation, Hamilton Regional Laboratory Medicine
Member, Faculty of Health Sciences Research Council

McMaster University
2N29A Health Sciences Centre
905-521-2100 x76274
Fax: 905-521-2338

Assistant: Cindy Bailey

Currently accepting Graduate Students
Currently accepting Post Doctoral Fellows

photo of Dr Hayward

Faculty Biography

Education and Professional Standing

  • PhD, (Gold Medalist) Medical Sciences, McMaster University, 1995
  • MD, University of Western Ontario, 1984
  • BSc, Biology, University of Western Ontario, 1980


Research and Clinical Focus

Dr. Hayward’s research laboratory at McMaster University is conducting bench to bedside studies of molecules important to blood clotting and vascular repair. Her group has discovered a new protein, named multimerinl, which functions as an adhesive protein in blood and blood vessels, and as a binding protein for coagulation factor V. They are investigating the formation and functions of platelets and megakaryocytes, including how they are altered by disease. Her group described the first bleeding disorder associated with increased urokinase-type plasminogen activator, a condition known as the Quebec platelet disorder and identified the genetic cause (duplication of the uPA gene) and how it causes bleeding. In conjunction with the Transfusion Research Program at McMaster University, and clinical services in the hospital, they are developing clinical history assessment tools to evaluate bleeding disorders, and are investigating causes of bleeding problems and platelet disorders.

Dr. Hayward is supported by operating grants from the Heart and Stroke Foundation of Canada and the Canadian Institutes of Health Research. She received the 1995 Governor General Gold Medal Award for her PhD studies, the Joe Doupe Young Investigator Award, the Gold Medal in Medicine from the Royal College of Physicians and Surgeons of Canada, the John Charles Polanyi Prize in Physiology and Medicine and was the first Canadian to receive an American Society of Hematology Scholar Award. She has been supported by a Career Investigator Award from the Heart and Stroke Foundation of Ontario, a Canada Research Chair in Molecular Hemostasis, and a Premier’s Research Excellence Award from the Government of Ontario.

Academic Interests

Dr. Hayward is the Associate Dean of Graduate Studies (Health Sciences) and is actively involved in the Medical Sciences Graduate Program as a supervisor of graduate students. She also teaches hematology residents and other post-graduate medical students during their coagulation rotation on topics such as bleeding disorders and laboratory tests. She has researched and published on clinician investigator training.

Team Members

Research Scientist: Dr. Subia Tasneem

Graduate Students: Alexander Leatherdale, Tanmya Sharma


Selected Publications

Castilloux JF, Moffat KA, Liu Y, Seecharan J, Pai M and Hayward CPM. A Prospective, Cohort Study of Light Transmission Platelet Aggregometry for Bleeding Disorders: Is Testing Native Platelet Rich Plasma Non-Inferior to Testing Platelet Count Adjusted Samples? Thromb Hemost 2011;106(4):675-682.

Hayward CP, Danoff D, Kennedy M, Lee AC, Brzezina S, Bond U. Clinician Investigator Training in Canada: a Review. Clin Invest Med 2011:34(4):E192

A Paterson,JM Rommens,B Bharaj, J Blavignac, I Wong, M Diamandis, JS Waye, GE Rivard, CPM Hayward. Persons with Quebec platelet disorder have a tandem duplication of PLAU, the urokinase plasminogen activator gene. BLOOD, 2010;115(6):1264-1266.

Hayward CP, Pai M, Liu Y, Moffat KA, Seecharan J, Webert KE, Cook RJ, Heddle NM. Diagnostic utility of light transmission platelet aggregometry: results from a prospective study of individuals referred for bleeding disorder assessments. J Thromb Haemost 2009; 7(4), 676-84.

Tasneem S, Adam F, Minullina I, Pawlikowska M, Hui SK, Zheng S, Miller JL, Hayward CP. Platelet adhesion to multimerin 1 in vitro: influences of platelet membrane receptors, von Willebrand factor and shear. J Thromb Haemost 2009;7(4), 685-92.

Badin MS, Graf L, Iyer JK, Moffat KA, Seecharan JL, Hayward CP. Variability in platelet dense granule adenosine triphosphate release findings amongst patients tested multiple times as part of an assessment for a bleeding disorder. Int J Lab Hematol 2016 Dec;38(6):648-657. doi: 10.1111/ijlh.12553. Epub 2016 Aug 30.


Badin MS, Iyer JK, Chang M, Graf L, Waye J, Rivard GE, Pare G, Hayward CPM. Molecular phenotype and bleeding risks of an inherited platelet disorder in a family with a RUNX1 frameshift mutation. Haemophilia. 2017 May;23(3):e204-e213. doi: 10.1111/hae.13169. Epub 2017 Feb 8.


Hayward CPM, Liang M, Tasneem S, Soomro A, Waye JS, Paterson A, Rivard G, Wilson M. The duplication mutation of Quebec platelet disorder dysregulates PLAU, but not C10orf55, selectively increasing production of normal PLAU transcripts by megakaryocytes but not granulocytes. PLoS ONE 2017 Mar 16;12(3):e0173991. doi: 10.1371/journal.pone.0173991.


Brunet J, Iyer JK, Badin MS, Graf L, Moffat KA, Timleck M, Spitzer E, Hayward CPM, Electron microscopy examination of platelet whole mount preparations to quantitate platelet dense granule numbers: Implications for diagnosing suspected platelet function disorders due to dense granule deficiency. Int J Lab Hematol 2018 Aug;40(4):400-407. Doi: 10.1111/ijlh.12801.


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